Objective:To explore the application effect of health education based on knowledge, attitude and practice model in improving readiness for hospital discharge and quality of discharge guidance for patients undergoing intracranial aneurysm surgery.Methods:Using the convenient sampling method, a total of 152 patients who underwent craniotomy and intravascular interventional embolization in Neurosurgery Department of the First Affiliated Hospital of Xinjiang Medical University from July 2019 to May 2020 were selected. According to the random number table method, they were divided into in the control group and the experimental group, with 76 cases in each group. The experimental group was given health education based on knowledge, attitude and practice model at basis of routine discharge guidance health education, while the control group was given routine discharge guidance health education. The scores of readiness for hospital discharge and quality of discharge guidance of the two groups were compared.Results:The total score of readiness for hospital discharge in experimental group was (90.80±7.63) , which was higher than that in control group (55.34±9.80) . The total score of quality of discharge guidance of the experimental group was (159.11±10.79) , which was higher than (80.45±12.65) of the control group, and the differences were statistically significant ( t= -24.893, -41.230; P<0.01) . Conclusions:The implementation of health education based on knowledge, attitude and practice model can effectively improve readiness for hospital discharge and quality of discharge guidance for patients undergoing intracranial aneurysm surgery.