Objective:To investigate the efficacy of modified encephalo-duro-arterio-synangiosis (EDAS) combined with superficial temporal fascia attachment-dural reversal surgery in treatment of ischemic cerebrovascular diseases.Methods:Twenty-four patients with ischemic cerebrovascular diseases, admitted to our hospital from December 2018 to June 2020, were selected. Their clinical data were retrospectively analyzed. All patients were treated by modified EDAS combined with superficial temporal fascia attachment-dural reversal surgery. CT cerebral perfusion (CTP) was re-examined 3 months after surgery to detect intracranial cerebral blood flow perfusion. Cephalic DSA was re-examined 6 months after surgery to observe the collateral circulation. Modified Rankin scale (mRS) was used to evaluate the good prognosis rate 6 months after surgery (mRS scores≤2 was defined as good prognosis).Results:Preoperative cerebral blood flow (CBF), time to peak of regional blood flow (rTTP), and regional mean transit time (rMTT) of 24 patients were (26.91±8.77) mL/(100 g·min), 17.57 (15.30, 19.55) s and 7.89 (6.39, 11.45) s; 3 months after surgery, the CBF, rTTP and rMTT were (33.74±11.23) mL/(100 g·min), 16.22 (13.84, 18.44) s, 6.16 (5.20, 10.38) s; significant differences were noted between the preoperative indexes and indexes 3 months after surgery ( P<0.05). Re-examination of the cranial DSA 6 months after surgery showed successful establishment of intracranial collateral circulation in all patients, and the good prognosis rate 6 months after surgery was87.5%. Conclusion:Modified EDAS combined with superficial temporal fascia attachment-dural reversal surgery is an effective method for ischemic cerebrovascular diseases, which can significantly increase the establishment of collateral circulation in the surgical area and prognosis of ischemic cerebrovascular diseases.