Pachycarpine given intravenously (10~20mg/kg) to anesthetized rabbits markedly increased the force of contraction of the anterior tibialis musculi for 30 minsimultaneously. It significantly increased the work made by rabbit anterior tibialis musculi. It markedly plo-longed the mice swimming time. It also significantly increased the muscle evoked action potential induced by electrical stimulation on anterior tibialis musculi of rabbit.