Objective To explore the symptoms of anxiety,family structure,and the distribution features of family about in-patients.And to find out the influence of the family structure on in-patients' symptoms of anxiety.The results would provide evidentiary support and suggestions for in-patients to improve quality of life and for prevention and intervention of anxiety.Methods Family table was used to register the family structure which was classified as the nuclear family,stem/expended family and other classification.The anxiety of in-patients was measured by self-rating anxiety scale.Results A total of 512 cases of in-patients completed the survey,there were 483 valid questionnaires.The rate of effective questionnaire was 94.34％.In family structure of in-patients,core family accounted for 48.65％,stem/expended family was 36.85％.The sex of family structure showed significant difference,the female proportion of the nuclear family was significantly higher than male.Among all in-patients,78.05％ did not have anxiety,low-level,medium-level,and severe anxiety showed no significant differences.The effects of anxiety on family structure had significant differences.The anxiety level of stem family was relatively higher.Conclusions Economic development and the population flow due to industrialization and globalization changed family structure of our country,especially in coastal de-velopment cities with fast economic development,fast-paced and stressful work,and it may affect the influ-ence of Chinese traditional family structure on anxiety of the in-patients.

Objective:To investigate and analyze the assessment of ultrasonic AFI on left ventricle for the effect of insulin pump infusion in treating type 2 diabetes mellitus(T2DM)complicated with left ventricular function of pulmonary tuberculosis(PTB).Methods:From December 2020 to October 2022,a total of 108 elderly patients with T2DM complicated with PTB,who were treated at the First Affiliated Hospital of Xinjiang Medical University,were selected as the observation group.At the same time,90 healthy individuals who underwent physical examinations at the same hospital were selected as the healthy control group.The patients of observation group received infusion therapy with insulin pump,and the ultrasonic automated function imaging(AFI)on left ventricle was adopted to assess the parameters of the function of left ventricle pre and post treatment.The indicators of left ventricle and blood glucose of healthy control group were examined.The differences of clinical indicators and ultrasonic parameters between two groups were compared.Results:Compared with the systolic blood pressure and fasting blood glucose levels pretreatment,these indicators post treatment were lower in observation group.Compared with the global longitudinal peak Strain in long axis(GLPS-LAX),global longitudinal peak strain in apical four-chamber view(GLPS-A4C)and global longitudinal peak strain average(GLPS-AVG)post and pretreatment of healthy control group,they decreased in observation group.Compared with GLPS-LAX and GLPS-AVG pretreatment of observation group,they were higher post treatment in observation group,and the differences were significant(t=2.846,4.926,P＜0.05),respectively.Conclusion:After patients with T2DM complicated with PTB are treated by insulin pump infusion,the assessment of ultrasonic AFI on the function of left ventricle finds that the function of left ventricle of patients is effectively improved.Dynamic detection of the above indicators has important clinical significance in assessing the curative efficacy of disease.

BACKGROUNDAn zidovudine (AZT)-substitution regimen containing 24-week stavudine (d4T) followed by long-term AZT for HIV therapy is potential to trade off short-term AZT-related anemia and long-term risks associated with d4T in resource-limited settings. However, evidence is scarce. This study aims to assess the efficacy and safety of AZT-substitution regimen, aiming to find a regimen with better efficacy, less adverse events, and more affordability in resource-limited settings.

METHODSThis prospective, multicenter study enrolled 499 (190 on d4T regimen, 172 on AZT regimen, and 137 on AZT-substitution regimen) HIV-1-infected subjects who initiated combined antiretroviral therapy and attended follow-up visits over 96 weeks from 2009 to 2011. Lamivudine (3TC) and either nevirapine (NVP) or efavirenz (EFV) were the other two drugs in the antiretroviral regimens. Virologic and immunologic responses and adverse events were monitored at baseline and at weeks 4, 12, 24, 36, 48, 60, 72, 84, and 96.

RESULTSIn terms of hematological adverse effects, AZT-substitution group had similar safety profiles to d4T group and was superior to AZT group. In comparison with AZT-substitution group, AZT group was associated with higher risk of developing anemia (adjusted hazard ratio (aHR) for anemia ≥ grade II, 8.44, 95% CI 1.81-39.46) and neutropenia (aHR for neutropenia ≥ grade II, 1.86, 95% CI 1.19-2.93). The prevalence of lipodystrophy in d4T group was 19.5%, while that in AZT-substitution group was zero. As to antiretroviral efficacy, these three groups showed no differences.

CONCLUSIONAZT-substitution regimen provides a relatively safe and effective first-line antiretroviral strategy in resource-limited settings.

Adult ; Anti-HIV Agents ; administration & dosage ; adverse effects ; therapeutic use ; Female ; HIV Infections ; drug therapy ; Humans ; Male ; Middle Aged ; Prospective Studies ; Stavudine ; administration & dosage ; adverse effects ; therapeutic use ; Zidovudine ; administration & dosage ; adverse effects ; therapeutic use