The hypercholesterolemia model was established by feeding mice on hypercholester-ol diet. FGS was administered to the hypercholesterolemia mice at the dose of 250,750 and 1500mg ? kg-1 ?d-1, respectively. On the 10,20,30 and 40th day, the serum cholesterol was determined. The results were as follows: 40th day the concentration of TC(Ⅰ,Ⅱ,Ⅲ) was 37. 6,54. 2 and 66. 2mg ?dL-1 lower than that of the control group; and the cocentration of LDL-C was 47. 6,86. 6 and 94. 4mg ?dL-1 lower than that of the control group; while the concentration of HDL-C was 16. 1,38. 2 and 36. 7mg?dL-1 higher than that of the control group. It was proved that FGS was an effective serum cholesterol regulator.

Thirst is one of the common complaints of critically ill patients, persistent and intense thirst is closely related to a variety of negative emotions, such as anxiety, depression, etc., which can cause restlessness, sleep disorders, and reduce the quality of life; at the same time, it can cause bacterial growth in the patient′s oral cavity, increasing the risk of secondary infection, thereby delaying the recovery of the disease and prolonging the length of ICU hospitalization. Therefore, this article reviews the current status, risk factors, and intervention strategies of thirst in critically ill patients in order to provide a reference and basis for medical staff to carry out thirst intervention measures in critically ill patients.

Objective To analyze the risk factors for lung infection in patients with craniocerebral injury after tracheotomy through Meta-analysis and provide a scientific reference for its prevention. Methods The inclusion and exclusion criteria were determined and the search strategies were designed. Two researchers independently searched both English and Chinese databases such as Cochrane Library, EMBASE, PubMed, CNKI, Wanfang and VIP (taking brain injury, craniocerebral injury, traumatic brain injury, tracheotomy, lung infection, pulmonary infection, risk factor, influencing factor and promotive factor as the key words) for literatures published since the databases were built to April 28th, 2019. RevMan 5.3 was used to analyze the data after the quality of literatures were assessed. Results Totally 9 articles were included, including 2112 patients with craniocerebral injury. Meta-analysis showed that diabetes [OR=3.36, 95％CI(2.49, 4.54),P< 0.01], use of hormones [OR=2.52,95％CI(1.83, 3.45),P< 0.01], Glasgow Coma Scale (GCS) score [OR=2.92,95％CI(1.95, 4.37),P< 0.01], hypoproteinemia [OR=3.18,95％CI(2.20, 4.60), P< 0.01], aspiration [OR=3.18, 95％CI(2.24, 4.51),P < 0.01], smoking [OR=1.87,95％CI(1.16, 3.00), P < 0.01], non-irrigable tracheal cannula [OR=2.54, 95％CI(1.71, 3.77),P<0.01]and tracheotomy time (>7 d) [OR=2.32, 95％CI (1.42, 3.79);P< 0.01]were the influencing factors for lung infection in patients with craniocerebral injury after tracheotomy. Conclusions Existing evidence shows that combined with diabetes, use of hormones, high GCS score, hypoalbuminemia, occurrence of aspiration, use of non-irrigable tracheal cannula, smoking, tracheotomy time > 7 d were independent risk factors for lung infection in patients with craniocerebral injury.

Objective:To systematically evaluate the qualitative research on experience of nurses in participating in treatment of acute respiratory infectious diseases, so as to provide evidence-based basis for subsequent formulation of intervention strategies and practices.Methods:Databases including PubMed, EMbase, Web of Science, The Cochrane Library, CNKI, Wanfang, and VIP databases for related qualitative research.The retrieval time was from the construction of databases to February 13, 2020. The 2017 version of JBI Critical Appraisal Tool for qualitative studies of Australian Evidence-Based Health Care Center was used for literature quality evaluation, and the collection and integration methods were adopted for Meta integration.Results:A total of 8 studies were included, 30 research results were refined, 8 new categories were formed and 3 integrated results were obtained. At the beginning of the epidemic, nursing staff volunteered themselves and showed a series of positive psychological experiences. As the treatment progressed, the nursing staff were under tremendous physical and psychological pressure and heavy workload. Through self-adjustment and encouragement and support from all parties of the society, the nursing staff finally realized their professional value, gained growth and put forward expectations and suggestions to the hospital management staff.Conclusions:The nurses are under great psychological pressure during the treatment and it should be taken seriously. In the process of participating in the treatment, it is necessary to dynamically evaluate psychological condition of nursing staff and timely provide support, guidance and encouragement to improve their psychological coping ability.

Objective:To establish a nursing intervention process for Intensive Care Unit (ICU) patients with thirst after cardiac surgery to guide clinical practice, so as to provide a basis for the scientific management of thirst in patients after cardiac surgery.Methods:We searched domestic and foreign databases to obtain and evaluate relevant literature on thirst in critically ill patients. After discussion by the research group, the first draft of the thirst intervention process was formulated. The Delphi method was used to conduct two rounds of expert consultation, and finally the nursing intervention process for ICU patients with thirst after cardiac surgery was determined.Results:Through two rounds of expert consultation, 4 first-level indicators (pre-intervention evaluation, graded intervention, post-intervention evaluation, health education) , 11 second-level indicators, and 29 third-level indicators were formed. The authority coefficients of the two rounds of expert consultation were 0.83 and 0.85 respectively, and Kendall's W were 0.259 and 0.214 respectively. Conclusions:Expert advice tends to be consistent, highly authoritative, and good coordination, which can provide a scientific management basis for the construction of nursing intervention process for ICU patients with thirst after cardiac surgery.