Taking care of children with Autism Spectrum Disorder (ASD) could be a demanding task for parents. Consequently, parentsof children with ASD may experience parenting stress and depression symptoms. This study examined parenting stressand depression symptoms among parents of children and adolescents with ASD. This study also examined the role of childcharacteristics (e.g., age, child quality of life and problem behavior) on parenting stress and depression symptoms and theeffect of parenting stress on parental depression. A total of 78 parents were examined using a questionnaire survey. Theresult indicated that parents caring a younger age group of children with ASD have higher levels of depression symptomscompared to parents caring for older group of children with ASD. The result also revealed a significant difference in levelof depression symptoms between parents with higher levels of parenting stress and parents with lower parenting stress.Only the children age significantly predicts depression symptoms in parents of children with ASD. This indicates thatchildren age is potential to affect mental health among parents of children with ASD.