Wechat as an emerging social media network,has the characteristics of delivering content in a timely manner,richness in content,convenient and unobstructed transmission channels,communication effect with personality and intelligence.It has an positive effect on medical humanities education,mainly to learn in a mobile learning environment,to strengthen the interaction between teachers and students,students and students;sharing educational resources utilization of public accounts;students and teachers can be equal to participate in the medical humanities education,to jointly promote the development of medical science humanistic education.Meanwhile,Wechat also has the side effects of making medical students excessively depend on Wechat's information and makes them hard to distinguish the true or false information and have to be in a state of blind conformity.Therefore,we must foster its strengths and circumvent weaknesses,and make WeChat truly effective tools to promote the development of medical humanistic education.

There are very close associations between traumatic and orthopedic teaching and medical imaging.Medical Imaging includes noumenal photograph,conceptual diagram,radiological imaging,operation photographic recording and computer-aided instruction courseware,etc.It is important to collect the medical imaging through various means and set up medical imaging resources library for traumatic and orthopedic teaching.

Management of acetabular deficiency in revision of hip arthroplasty can be extremely challenging. A successful outcome requires careful preoperative planning, identification of complex defects, and stable reconstruction. Now, acetabular reconstructions that are conducted with autograft and allograft filling the defect and special techniques are effective. As more revisions of total hip arthroplasty take place in clinic, a systematic approach to diagnosis and treatment becomes more important. This paper reviews the progress made in classification and reconstruction of acetabular defects.

[Objective]To investigate the effects of bone marrow stromal stem cells(MSCs) on the bone defect around the implant and the osteointegration of implant-bone interface.[Method]Fifteen healthy clean New Zealand rabbits were studied.MSCs were separated,cultured and induced to osteoblasts.Cancellous bone defects(0.6?1.2 cm)were created in bilateral femur condyle in rabbits.Titanium alloy columns(0.3?1.0 cm)were implanted into both defects.Tissue engineering bone was implanted around the left titanium alloy implant,but only hydroxyapatite ceramic in the right.The biological characteristics were evaluated by X-ray examination,SEM,energy dispersive X-ray analysis and histologic studies at 4,8,and 12 weeks postoperatively.[Result] X-ray examination showed the density of bone tissue around the implant was aequalis.The interspace between implant and bone was filled with lots of bone trabeculae in the experimental group at 12 weeks postoperatively.The density of bone tissue was inhomogeneous,and low-density umbra existed in the interspace in the control group.Energy dispersive X-ray analysis showed the content of the Ca and P in the experimental group was statistically higher than that in the control group at different time points(P0.05.The ratio of Ca to P became higher and reaching the peak level at 8 week.Histological study showed the bone defects around the implant were repaired by new mature bone in the left at 12 weeks postoperatively,while in the right no new bone was found at any time point.[Conclusion]The compounds of hydroxyapatite ceramic and osteoblasts induced by MSCs can repair the bone defect around the implant and improve the osteointegration of implant-bone interface.

[Objective]To dynamically monitor revascularization and metabolism of tissue-engineered bone graft in repairing bone defects by radionuclide bone imaging.[Method]Twenty-four healthy New Zealand rabbits were studied.Mesenchymal stem cells(MSCs) were separated and cultured from bone marrow.Cancellous bone defects(0.6 cm?1.2 cm) were created on bilateral femoral condyles in rabbits.The compound of coral hydroxyapatite ceramic(CHA) and defects were treated with the induced osteoblasts inplanted into the left defects(experimental group).While CHA alone was used for the right(control group).The counts of regions of interest(ROI) was evaluated by radionuclide bone imaging at 4,8 and 12 weeks postoperatively.[Result]ROI in the experimental group was significantly higher than that of control group at 4,8 and 12 weeks postoperatively.ROI in either group had a tendency to increase with time.Eight weeks postoperatively,ROI in experimental group tended to increase at a lower speed,while ROI in control group had a tendency to increase at a higher speed.ROI in either group reached a peak at 12 weeks postoperatively.[Conclusion]The tissue-engineered bone graft is an effective method for repairing cancellous bone defects.Radionuclide bone imaging can dynamically monitor the changes of revascularization and metabolism of tissue-engineered bone graft.

Objective To investigate the different doses of dexmedetomidine on reducing the effects of restlessness after anesthesia.Methods Forty-eight patients who occurred restlessness after general anesthesia were collected and randomly divided into A,B,C group (16 cases in each group).Dexmedetomidine were given at dose of 0.3 μg/kg,0.5 μg/kg,1.0 μg/kg for treatment as A,B,C group.Blood pressure,heart rate,Riker sedation-restlessness (SAS) score and other changes of patients were recorded at different time points after treatment.Results SAS scores were significantly lower in B,C groups than that in A group (P ＜ 0.05) at immediately after administration and 5 min and 10 min after administration.Systolic pressure and heart rate were significantly lower in C group than in B,A group (P ＜ 0.05) at immediately after administration and 5 min after administration.Only the heart rate in B group at immediately after administration was lower than that in A group.Time in the recovery room in B group was (37.5 ± 6.4) min,significantly lower than A group and C group ((43.2 ± 8.9) min,(47.5 ± 9.8) min ; F =14.362 ; P ＜ 0.001).Conclusion Dexmedetomidine is a more ideal sedation drug and 0.5 μg/kg dexmedetomidine can reduce restlessness and cardiovascular reactions in patients with restlessness after general anesthesia,which is the best recommending therapeutic dose.

Objective To establish a method of the dissolution test of Xinkeshu capsule and study the dissolution behavior of sodium Danshensu, protocatechuic aldehyde, salvianolic acid B and puerarin in Xinkeshu capsule.Methods Using the dissolution determination first law of Chinese Pharmacopoeia 2010 II edition, according to the dissolution test conditions in Japan′s“quality of medical drugs information set”, different Xinkeshu capsule were inspected in pH 1.2 solution,pH 4.0 acetate buffer, pH 6.8 phosphate buffer and water.The HPLC gradient elution method was adopted to determine the dissolution of sodium Danshensu,protocatechuic aldehyde,salvianolic acid B and puerarin in Xinkeshu capsule.ResuIts Dissolution of sodium Danshensu, protocatechuic aldehyde, puerarin and salvianolic acid B of Xinkeshu capsule sample from each manufacturer were in good condition, 45min dissolution were 80% and dissolution uniformity.ConcIusion The method is simple, accurate and reproducible for the dissolution determination of this capsule .

Objective To observe the effect of ankle slow lengthening fusion on old ankle injury .Methods Totally 3 cases of old ankle injury ,were retrospectively analyzed .The new method of ankle slow lengthening fusion was adopted for conducting treat‐ment .Intraoperative ankle osteotomy and Orthofix external fixation were performed ,ankle slow lengthening was started on postop‐erative 7 d ,and the ankle joint gap was pulled for 1-2 cm ,the double lower limbs were basically equal length and the ankle reached completely bony fusion ,the external fixator was taken out and then weight‐bearing walking started .Results The 10 -23 months follow up was performed ,averaged 16 months .Three cases of ankle joint obtained bony fusion in postoperative 9 months and the ex‐ternal fixator was dismantled .By adopting the AOFAS foot score ,the average score in 3 feet was increased from preoperative 25 .6 points to postoperative 76 .3 points at the time of follow‐up .Conclusion Ankle slow lengthening fusion is an effective treatment method for old ankle joint injury .

Objective To analyze the risk factors for venous thromboembolism(VTE) in hospitalized patients undergoing to‐tal hip arthroplasty (THA) or total knee arthroplasty (TKA) at the perioperative period .Methods One hundred and seventy‐four in hospitalized patients who was given THA or TKA from October 2012 to July 2013 were enrolled in this prospective cohort stud‐y .There are a total of 205 cases of surgery ,including 132 T HAs in 122 patients and 73 TKAs in 52 patients .All patients were given Color Doppler Ultrasonography of lower limbs to detect DVT in 3 to 5 days after operation and preoperative .Then the patients were divided into two groups ,the DVT group and the non DVT group according the Ultrasonography results .More than ten factors such as age ,gender ,hypertension in DVT formation were detected .Then their correlation was analyzed .The key influencing factors for DVT were selected .Results Forty‐three patients developed DVT after operation ,the incidence of DVT was 24 .7% .Age≥ 70 years ,rheumatoid and relatively lower PT‐INR before surgery has a statistical significance (P<0 .05);elevated plasma D‐dimer val‐ue before surgery and general anesthesia has a highly statistical significance (P<0 .01) .A preoperative plasma D‐dimer cutoff value as a diagnostic test was calculated as 764 μg/L .Conclusion Age≥70 years old ,relatively lower PT INR ,preoperative elevated plasma D‐dimer value ,rheumatoid and general anesthesia were the risk factors for DVT formation after THA or TKA .A preopera‐tive plasma D‐dimer cutoff value as a diagnostic test was obtained as 764 μg/L .

Experiments in vitro demonstrated for the first time that an EtOAc extract of roots of Rubus crataegifolius Bge.can markedly inhibit the for mation of lipid peroxide in rat brain,heart. liver and kidney tissucs. When administered intragastrically for 15 successive days,the EtOAc extract markedly inhibited the formation of lipid peroxide in plasma and tissues of liver and brain of mice. The above results showed that the EtOAc extract from roots of R. crataegifolius Bge.had anti-lipid peroxidation effect.