Objective To investigate the mental health level and stressors of medical students in a university in Xinjiang in the con-text of healthy China and analyzing their influencing factors.Methods From February to April 2021,a stratified cluster random sampling method was used to select 4421 medical students from a university in Xinjiang.Questionnaires were administered using Symptom Check List 90(SCL-90)and the Stressor Scale for Contemporary College Students.Results 25.26％medical survival in varying degrees of SCL-90scale listed symptoms;SCL-90scores on all factors were lower than the national norm for university students in some regions,the SCL-90scale scores for somatization,obsessive-compulsive symptoms,depression,and terror factors were significantly higher for girls than for boys(P＜0.05);the main stressors were developmental distress type;students from outside the Xinjiang had higher scores on developmental distress stressors than students from inside the Xinjiang(P＜0.05);girls were more stressed than boys,female students scored higher on developmental distress,personal management,and negative event stressors than male students(P＜0.05).Pearson cor-relation analysis showed that students'mental health level was positively correlated with the source of pressure(P＜0.05).Conclusion In a university in Xinjiang,25.26％of medical students had different degrees of mental health problems,and the mental health level of fe-male students was inferior to that of male students.Mental health level is positively correlated with stress,and developmental distress stress is the main source of stress for medical students.There are some differences in mental health level and stressors of medical students with different characteristics.