Objective To explore the expression of LGALS4 gene and its clinic significance in colorectal cancers (CRC).Methods 7 fresh CRC and their matched colorectal tissue were collected and mRNA expression level of LGALS4 was examined.83 CRC and 31 normal colorectal paraffinembedding samples were collected and the expression of LGALS4 protein was detected in these samples by immunohistochemistry.The correlation of LGALS4 expression and clinical pathology features was analyzed in the CRC.Results Compared to 7 normal colorectal tissues,LGALS4 mRNA was downexpressed in all 7 corresponding colorectal cancer tissues.Immunohistochemistry analysis indicated that,compared to normal colorectal tissues,the expression level of LGALS4 protein was significantly decreased in CRC [77.4 ％ (24/31)vs 30.1％ (25/83)] (x2 =20.606,P ＜0.001).Furthermore,reduced LGALS4 protein expression was closely associated with the tumor differentiation degree (x2 =4.454,P =0.043),T classification (x2 =4.404,P =0.05),lymph node metastasis (x2 =6.553,P =0.016),and Dukes stage (x2 =4.953,P =0.033) in CRC.Conclusion The lower LGALS4 protein expression hints higher malignancy degree of CRC.It may be an unfavorable biomarker of CRC.