Haemophilus influenzae (Hi)is an important human pathogen that causes severe infections inclu-ding meningitis,bacteremic pneumonia and sepsis,mostly affecting young children.The resistance of Hi to antimicro-bials has risen and wide variations exist in antibiotic resistance,both geographically and over time.The main mecha-nisms of resistance of Hi are those to β-lactam antibiotics.Antibiotic utilization is the main risk factors for the deve-lopment of antimicrobial resistance.Third -generation cephalosporins is the most effective antibiotic agent to treat the infections of Hi in children population.With continued research,progress toward a broadly effective vaccine to prevent infections caused by Hi is expected in the near future.

Objective To study MRI and CT manifestations and characteristics of primary intracranial lymphoma,and improve the diagnosis and differential diagnosis.Methods Imaging features of primary intracranial lymphoma in 1 1 patients proved by pathology were analyzed retrospectively.Results 9 cases were solitary tumor and 2 cases multiple lesions.Tumors were located in the frontal lobe in 2 cases,the corpus callosum 2 cases,near meningeal 2 cases,the occipital lobe 3 cases.Tumors presented as isodensity or slight hyper density on CT and equal or slight long T1 and T2 signal on MRI.All the lesions were found with obvious homogenous en-hancement;in which 2 cases were found meningeal strengthened;1 case room tube film strengthened.There were slight space occup-ing effect,mostly mild to moderate edema,severe edema in 2 cases.7 typical cases presented “umbilicus sign”,“notch sign”,“lobu-lated”,“incision sign (fist sign)”,and “half month”and so on.Conclusion Imaging manifestations of primary intracranial lymphoma has certain specificity and MRI plays an important role in making accurate diagnosis in the position and qualitative diagnosis.

ObjectiveTo discuss the diagnosis and treatment methods of endometriosis, so as to improve the diagnosis and treatment level. MethodThe clinical data of 236 patients with endometriosis was analyzed retrospectively, all the patients were treated with surgery and mifepristone. ResultOf the 236 patients, 69 to retain reproductive function routine surgery, the cure rate was 60.9％(42/69); 146 to retain ovarian function routine surgery, the cure rate was 58.9％(86/146); 21 to undergo radical surgery, 12 patients with menopause symptoms. ConclusionSurgical treatment with mifepristone in endometriosis can get better results.

Objective To observe the application of cesarean section and vaginal delivery in parturient term pregnancy with fetal distress. Methods One hundred and six cases of parturient term pregnancy with fetal distress were selected, SO cases of cesarean section as group A, 56 cases of vaginal delivery as group B, newborn outcome and condition of the large maternal cervix data when fetal distress between two groups were compared. Results The neonatal asphyxia rate was 14.0% (7/50) in group A and 16.1 % (9/56 ) in group B, there was no significant difference between two groups (P＞0.05); the rate of the large maternal cervix data in delitescence in group A was higher than that in group B [54.0% (27/50) vs. 26.8% (15/56) ](P＜ 0.05); the rate of the large maternal cervix data in active stage deceleration phase in group A was lower than that in group B [4.0%(2/50) vs. 23.2%(13/56)](P＜0.05). Conclusion Cesarean section and vaginal delivery in parturient term pregnancy with fetal distress can get a good neonatal outcomes, maternal clinical condition should select the appropriate surgical approach, and effort to reduce cesarean section rates.

Objective To analyze the CT characteristics and misdiagnosis reasons in mass-forming intrahepatic cholangiocarcinoma(ICC)and liver abscess to reduce the misdiagnosis rate.Methods CT features of 21 patients with mass-forming ICC and 20 patients with liver abscess proved by operation or puncture pathology were analyzed,in which 10 cases of mass-forming ICC were misdiagnosed as liver abscess.CT plain scan and three period enhanced scan were performed in 41 cases.Results Irregular edge enhancement rings,irregular patch or flocculent strengthened in delayed phase,arterial through surrounded lesions,liver capsule shrinkage,tissue nodule in intrahepatic bile duct,intrahepatic bile duct dilatation,hilar and retroperitoneal lymph node enlargement,portal vein invasion stenosis or occlusion,which possibility prompted to be the diagnosis of mass-forming ICC.Regular shape,slippery and intact ring-wall,edema syndrome around the ring wall,separate and annulate enhancement in delayed phase,reduction of tumor size and similar low density liquid in ring hints prompted to be the diagnosis of liver abscess.Liver abscess appears abnormal perfusion likely and significant.Conclusion Mass-forming ICC sharing similar imaging characteristics with liver abscess,having characteristic CT features.A comprehensive analysis of multiple signs may be helpful to arrive at a correct diagnosis.

Objective To compare clinical efficacy between improved vaginal hysterectomy (IVH)and traditional vaginal hysterectomy (TVH) and its influences on blood glucose and serum corticosteroid levels.Methods One hundred patients undergoing hysterectomy were divided into using IVH (treatment group,50 patients) and TVH (control group,50 patients).Clinical efficacy,blood glucose and serum corticosteroid levels were compared between two groups.Results There was no significant difference in operation time between two groups (P＞ 0.05).The amount of intraoperative bleeding,postoperative exhaust time and postoperative vaginal bleeding time in treatment group were significantly less than those in control group [(86.7 ± 5.7) ml vs.(131.2 ± 14.5) ml,(24.8 ± 12.9) h vs.(42.8 ± 17.7) h,(16.5 ± 2.9) d vs.(24.3 ±6.7) d,P ＜ 0.05],and the time of blood glucose and serum corticosteroid levels returned to normal levels in treatment group were much earlier than those in control group.Conclusion The clinical efficacy of IVH is preonunced,and postoperative stress reaction is mild.

Endemic arsenicosis is a disease with complex systemic damage,but the mechanism and its control strategy are mostly focused on a single organ or system damage caused by arsenic,and the systemic damage of arsenic exposure remains not fully understood.In recent years,considerable progress has been made in the field of immunology,which made an important contribution for the pathogenic mechanism of various complex diseases,and also brings a new dawn for its prevention and treatment.In consequence,a breakthrough progress is expected to make in aspects of the mechanism and its control strategy of arsenic caused systemic damage from the perspective of immunology.

Endemic arsenicosis is one of the national key endemic diseases in our country. However, due to obscure mechanism of arsenic poisoning, lack of early diagnostic indicators and specific validated therapy, the ideal control of endemic arsenicosis has not yet been obtained. To date, considerable progress has been made to address endemic arsenic poising and also formed various hypotheses, whereas simultaneously there are some problems and the insufficiency such as unclear relationship among those hypotheses and the gap between mechanism studies and translational application. In consequence, enhancing the interactive effects among various mechanisms of arsenic poising and improving its translational application could have more realistic significance for scientific prevention and control of endemic arsenicosis.

Objective To investigate the correlation between family environment,cognitive disposition,self-esteem and adolescent social phobia.Methods 110 adolescents with social phobia and 142 healthy control subjects were selected.They were surveyed by Family Environment Scale of Chinese version (FES-CV),cognitive appraisal orientation test (CAOT),and Self-Esteem Scale (SES).Moreover,the adolescents with social phobia were administered with Social Avoidance and Distress Scale (SAD).Results When compared with the controls,the score of adolescent social phobia group showed significantly lower score in total and optimistic factor of CAOT,cohesion,expressiveness,achievement,activerecreational orientation,organization and self-esteem; but higher in conflict factor.The analysis of the results showed that SAD was significantly and negatively correlated with the score of total and optimistic factor of CAOT,cohesion,expressiveness and SES,while was significantly and positively correlated with the score of conflict factor.The seriousness of the condition was significantly negatively related to the score of optimistic factor,cohesion,expressiveness and SES,while the onset age was significantly positively related to them.The clinical course was significantly negatively related to the cohesion,expressiveness and self-esteem,while was significantly positively related to the score of conflict.Conclusions Negative cognitive disposition,lower cohesion,less expressiveness,higher conflict and lower self-esteem are the major factors that could affect the onset of adolescent social phobia.The more negative the cognitive disposition is,the lower the cohesion,the expressiveness and the self-esteem are,the earlier the onset age and the more serious the illness is.The longer clinical course is in ration to lower cohesion,less expressiveness,higher conflict and lower self-esteem.

Traditional Chinese medicine (TCM) has been used to prevent disease for thousands of years. However, the actual value of TCM has not been recognized adequately due to the lack of scientific approaches to its study . Fortunately, metabolomics becomes practically available and consists with the holistic thinking of TCM. The metabolomics can serve as a new strategy for evaluating the efficacy of TCM . This review summarized applications of metabolomics in special TCM field with an emphasis on biomarker discovery.