Ankle brachial index(ABI),as a non-invasive and simple detection method,can be used to accurately assess and diagnose the severities and prognosis of the diabetic lower extremity arterial disease,cardiovascular and cerebral vascular diseases.

Objective To investigate the relationship between indoor radon concentration and air exchange rate for new residential building.Methods The indoor radon concentration and air exchange rate were measured in two new roughcast houses in Guangzhou and Hefei,respectively.The radon concentration was measured using radon instrument.The air exchange rate was measured by using tracer gas dilution method.Results The indoor radon concentrations measured in Guanzhou for two bedrooms in a 48-hour closed condition were 106 and 115 Bq/m3,the range of 17-181 and 6-224 Bq/m3.Air exchange rates were 0.16/h and 0.21/h.In Hefei,the twice measured values for one bedroom were 148 and 186 Bq/m3,the range of 8-224 and 14-290 Bq/m3,and air exchange rates were 0.14/h and 0.12/h.The indoor radon concentration exponentially decreased with the increase of air exchange rates.Conclusions Attention should be paid to the indoor radon pollution issue that may arise in new residential buildings of energy-saving design due to low air exchange rate.

OBJECTIVE: The aim of this study is to investigate the incidence and natural history of secretory otitis media(SOM) and hearing loss in newborns and infants with cleft palate, consequently, define its audiological criteria and to predict SOM early. METHOD: Seventy-three newborns and infants with a cleft palate (146 ears) were monthly estimated by tympanogram, static compliance, acoustic stapedius reflex and auditory brainstem response (ABR) under natural sleep within one year of age. RESULT: Au the infants with cleft palate had the suspected SOM in the first 6 months of life. Among children with cleft palate, the suspected SOM were most prevalent in the 3-month-age. 78. 8% infants with cleft palate had the confirmed SOM in the first 12 months of life. SOM were most prevalent in the 6-month-age. The SOM prodromal period was averagely 3. 8 months from suspected SOM to confirmed SOM. 56. 2% infants with cleft palate had a conductive hearing loss in the first 12 months of life. The conduction hearing thresholds of ABR (2-4 Hz) were averagely 48. 6 dBnHL. CONCLUSION The highest incidence of SOM and hearing loss in children with cleft palate appear in infants in the first 1 year of life. The process of SOM and hearing loss onset is progressive process. The infants with cleft palate should be estimated by ABR and acoustic immittance audiometry in each period of 2 or 3 months after birth.
Cleft Palate ; complications ; Female ; Hearing Loss ; epidemiology ; etiology ; Humans ; Incidence ; Infant ; Infant, Newborn ; Male ; Otitis Media with Effusion ; epidemiology ; etiology

Objective:To construct a risk nomogram model for cancer-related fatigue in non-small cell lung cancer patients undergoing chemotherapy, and to verify the application value of the model.Methods:From from January 2017 to December 2021, 520 non-small cell lung cancer patients undergoing chemotherapy admitted to Taizhou People's Hospital and the Second People's Hospital of Lianyungang were selected as the research objects using the convenient sampling method, 400 patients admitted from January 2017 to February 2020 were selected as the model group, and 120 patients admitted from April 2020 to December 2021 were selected as the verification group. Lasso analysis and Logistic regression analysis were used to explore the risk factors of cancer-related fatigue in non-small cell lung cancer patients undergoing chemotherapy. R 4.1.2 software was used to establish a risk nomogram model to predict the risk of cancer-related fatigue in non-small cell lung cancer patients undergoing chemotherapy, and to verify the application value of the model.Results:The incidence of cancer-related fatigue in the model group was 65.5% (262/400) . Logistic regression analysis showed that age≥60 years old, female, living alone, TNM stage (Ⅲ-Ⅳ stage) , poor sleep, depression, frequency of chemotherapy>2 times and percentage of forced expiratory volume in one second to the predicted value (FEV 1%) <70% were the risk factors of cancer-related fatigue in non-small cell lung cancer patients undergoing chemotherapy. The results of risk nomogram model showed that consistency index of the model group and the verification group were 0.846 (95% CI: 0.810-0.889) , 0.887 (95% CI: 0.857-0.917) respectively. The calibration curve showed that the actual and predict values of the model group and the validation group had a good fitting degree. The areas under receiver operating characteristic curve of the model group and the validation group were 0.845 and 0.866, respectively. The decision curve showed that the predictive graph of cancer-induced fatigue in non-small cell lung cancer patients undergoing chemotherapy had good clinical efficacy. Conclusions:Age≥60 years old, female, living alone, TNM stage (Ⅲ-Ⅳ) , poor sleep, depression, frequency of chemotherapy>2 times and FEV 1%<70% are the risk factors of cancer-related fatigue in non-small cell lung cancer patients undergoing chemotherapy, the risk nomogram model established based on the above risk factors is helpful to developing the screening and prevention measures of patients at high-risk of cancer-related fatigue.