ObjectiveTo discuss the diagnosis and treatment methods of endometriosis, so as to improve the diagnosis and treatment level. MethodThe clinical data of 236 patients with endometriosis was analyzed retrospectively, all the patients were treated with surgery and mifepristone. ResultOf the 236 patients, 69 to retain reproductive function routine surgery, the cure rate was 60.9％(42/69); 146 to retain ovarian function routine surgery, the cure rate was 58.9％(86/146); 21 to undergo radical surgery, 12 patients with menopause symptoms. ConclusionSurgical treatment with mifepristone in endometriosis can get better results.

Objective To identify the posttraumatic growth (PTG) level of cancer patients and to examine the effects of rumination on posttraumatic growth of cancer patients.Methods A total of 312 cancer patients were recruited by convenience sampling.A cross-sectional study was conducted in cancer patient by means of questionnaires that included demographic scale,Event Related Rumination Inventory and the Posttraumatic Growth Inventory (PTGI).Results A total score of event-related rumination in cancer patients was 25.13±11.11,and the total score of posttraumatic growth was 67,21±14.66.The PTG was positively correlated to event-related rumination in cancer patients (r=0.384,P ＜ 0.01).Multiple stepwise regressions indicated that the variables of deliberate of rumination,gender,age,degree of psychological distress,intrusive rumination and education level were main predictors of PTG.Among those deliberate of rumination positively predicts PTG,while intrusive rumination negatively predicts PTG.The level of PTG in female gender cancer patients were higher than male patients,younger age and high education level,less psychological distress patients related to higher PTG.Conclusions Cancer patients reported a lower level of rumination and PTG.Clinical healthcare providers should inspire and promote cancer patients' deliberate rumination,decrease their intrusive rumination,pay attention to male,more psychological distress,older age and lower education level patients,in order to facilitate patients' PTG and then improve their quality of life.

Haemophilus influenzae (Hi)is an important human pathogen that causes severe infections inclu-ding meningitis,bacteremic pneumonia and sepsis,mostly affecting young children.The resistance of Hi to antimicro-bials has risen and wide variations exist in antibiotic resistance,both geographically and over time.The main mecha-nisms of resistance of Hi are those to β-lactam antibiotics.Antibiotic utilization is the main risk factors for the deve-lopment of antimicrobial resistance.Third -generation cephalosporins is the most effective antibiotic agent to treat the infections of Hi in children population.With continued research,progress toward a broadly effective vaccine to prevent infections caused by Hi is expected in the near future.

To investigate the effects of iron deficiency on cochlear structure and functions, an auditory electrophysiological and histopathological study was conducted in the rats which were fed with either a basic Fe-deficient diet or a standard diet.It was found in iron-deficient rats that the incidence of threshold elevation (more than 15 dB) in both auditory brain-stem response and electrocochleogram-N1Was 31.85%, and cochlear histopathological changes were stria atrophy and reduction of spiral ganglion cells. No change was found in the controls.These findings suggest that iron deficiency could be a direct cause of sensorineural hearing loss, or could provide a pathological basis for cochlear deafness.

Objective To explore the feasibility of classical intrafascial supracervical hysterectomy (CISH). Methods Clinical data of 65 cases of classical intrafascial supracervical hysterectomy were reviewed. Results The classical intrafascial supracervical hysterectomy was accomplished under laparoscope in all the 65 cases. The operation time was 110 7?29 9 min, and the intraoperative blood loss was 45 3?22 1 ml. No conversion to open surgery was required. No severe complication occurred. Conclusions Classical intrafascial supracervical hysterectomy demonstrates excellent safety, minimal invasion, less blood loss, and quick recovery to normal activities. Laparoscopy; Classical intrafascial supracervical hysterectomy

Objective To compare the effect of adenoidectomy with adenoidectomy under nasal endoscope in the treatment of adenoid hypertrophy.Methods 120 cases with adenoid hypertrophy were selected as the research subjects.The patients were randomly divided into two groups by random number table,and the control group(n =60) was treated with routine adenoidectomy.The surgical treatment of the observation group(n =60) was performed under nasal endoscope.Surgical treatment,surgery related indicators (operative time,the average amount of bleeding,hospitalization time and the incidence of postoperative complications) were compared between the two groups.Before and after operation,acoustic rhinometry examination of nasopharynx was used to detect the smallest cross-sectional area and compared.Results In the observation group,the operation time,the average amount of bleeding,hospitalization time and incidence rate of postoperative complication were (5.32 ± 2.05) min,(51.05 ± 8.26) mL,(8.50 ± 2.50) d,15.00％,respectively,which in the control group were (8.56 ± 2.68) min,(78.45 ± 10.15) mL,(12.00 ± 3.50) d,36.67 ％,respectively,there were significant differences between the two groups (t =7.44,15.98,6.30,x2 =7.35,all P ＜0.05).12 months after surgery,the nasal minimal cross-sectional area of nasal pharynx in the observation group was (1.99 ± 0.51) cm2,which of the control group was (1.81 ± 0.48) cm2,there was significant difference between the two groups(t =3.99,P ＜ 0.05).Conclusion Compared with conventional adenoidectomy,endoscopic adenoidectomy in the treatment of adenoid hypertrophy has good clinical curative effect,less bleeding,shorter operative time and less postoperative complications and other advantages,it is worthy of promotion.

Objective To study MRI and CT manifestations and characteristics of primary intracranial lymphoma,and improve the diagnosis and differential diagnosis.Methods Imaging features of primary intracranial lymphoma in 1 1 patients proved by pathology were analyzed retrospectively.Results 9 cases were solitary tumor and 2 cases multiple lesions.Tumors were located in the frontal lobe in 2 cases,the corpus callosum 2 cases,near meningeal 2 cases,the occipital lobe 3 cases.Tumors presented as isodensity or slight hyper density on CT and equal or slight long T1 and T2 signal on MRI.All the lesions were found with obvious homogenous en-hancement;in which 2 cases were found meningeal strengthened;1 case room tube film strengthened.There were slight space occup-ing effect,mostly mild to moderate edema,severe edema in 2 cases.7 typical cases presented “umbilicus sign”,“notch sign”,“lobu-lated”,“incision sign (fist sign)”,and “half month”and so on.Conclusion Imaging manifestations of primary intracranial lymphoma has certain specificity and MRI plays an important role in making accurate diagnosis in the position and qualitative diagnosis.

Measurement of serum Fe concentration and its physiologic variation were carried out in 240 cases with sensorineural deafness and 60 healthy subjects.The mean value and standard deviation of serum Fe concentration was 148.17?37. 64?g/dl in normal individual and 115.19?16.98?g/dl in the patients with senso-rineural deafness.The difference in serum Fe concentration between the above two groups was highly significant statistically(p

OBJECTIVE: To investigate the anti-tumor activity of adriamycin-loaded chitosan nanoparticles surface-modified with glycyrrhizin on human hepatoma cell line SMMC-7721. METHODS: Inhibition effect of drug-loaded nanoparticle on the proliferation of SMMC-7721 cells was determined with MTT method. Intra-cellular distribution of nanoparticles and morphological change of SMMC-7721 cells before and after treatment were observed by confocal laser scanning microscope (CLSM) and the apoptosis induced by adriamycin was measured by TUNEL assay. RESULTS: The inhibition effect of adriamycin-loaded chitosan nanoparticles surface-modified with glycyrrhizin on the proliferation of SMMC-7721 cells increased 6.36 times lower in comparison with free drugs. The inhibition effect of adriamycin-loaded chitosan nanoparticles had no obvious improvement. Nanoparticles surface-modified with glycyrrhizin promoted the distrubition of adriamycin in the nucleus, so as to promote the anti-tumor activity of adriamycin. TUNEL assay indicated that nanoparticles surface-modified with glycyrrhizin induce DNA fragmentation and nucleus breakdown to induce the apoptosis of SMMC-7721 cells. CONCLUSION: Adriamycin-loaded chitosan nanoparticles surface-modified with glycyrrhizin can used as potential active hepatocyte-targeted delivery carrier. Pharmacokinetic evaluation of it is worthy of further studing.

In order to study the pathogenesis of simple obesity in relation to genetic and environmental factors,I,202 primary re-latives of 200 cases of simple obesity and 939 primary relatives of 200 normal controls were investigated. The results were as follows: The incidence of obesity is higher in the parents and siblings of obese subjects than that in the normals. The hereditary degree is 83.1% in these patients with simple obesity. Asignificant difference of the incidence of obesity was found between the normal controls (11.7%) and the primary relatives of obese cases (34.4%). The latter is close to the square root of the former and is much less than that of the monofactorial inheritance. Therefore, genetic factors and multifactorial inheritance appear to play a role in the pathogenesis of obesity.