Objective To study the effect of acupuncture and medication on plasma ealcitonin gene-related peptide(CGRP) levels in patients with acute cerebral infarction. Methods 90 patients with simple obesity were ran-domly divided into acupuncture and medication group( n = 45) and medication group( n = 45 ). All patients were ex-amined the plasma level of CGRP to observe clinical curative effect before and after 1 month treatment. Results The total effective rate of acupuncture and medication group 91.1% (41/45) was significantly higher than that in medication group 77.8 % (36/45) (P < 0.05) ; after treatment the plasma level of CGRP in two groups were signifi-candy higher than those before treatment(P < 0.05) , acupuncture and medication group was significantly higher than that in medication group (P < 0.05). Conclusion Acupuncture in combination with drug could cut down nerve cell damage, and it may be significantly related to levels of CGRP in patients with acute cerebral infarction.

ObjectiveTo discuss the diagnosis and treatment methods of endometriosis, so as to improve the diagnosis and treatment level. MethodThe clinical data of 236 patients with endometriosis was analyzed retrospectively, all the patients were treated with surgery and mifepristone. ResultOf the 236 patients, 69 to retain reproductive function routine surgery, the cure rate was 60.9％(42/69); 146 to retain ovarian function routine surgery, the cure rate was 58.9％(86/146); 21 to undergo radical surgery, 12 patients with menopause symptoms. ConclusionSurgical treatment with mifepristone in endometriosis can get better results.

Objective To observe the application of cesarean section and vaginal delivery in parturient term pregnancy with fetal distress. Methods One hundred and six cases of parturient term pregnancy with fetal distress were selected, SO cases of cesarean section as group A, 56 cases of vaginal delivery as group B, newborn outcome and condition of the large maternal cervix data when fetal distress between two groups were compared. Results The neonatal asphyxia rate was 14.0% (7/50) in group A and 16.1 % (9/56 ) in group B, there was no significant difference between two groups (P＞0.05); the rate of the large maternal cervix data in delitescence in group A was higher than that in group B [54.0% (27/50) vs. 26.8% (15/56) ](P＜ 0.05); the rate of the large maternal cervix data in active stage deceleration phase in group A was lower than that in group B [4.0%(2/50) vs. 23.2%(13/56)](P＜0.05). Conclusion Cesarean section and vaginal delivery in parturient term pregnancy with fetal distress can get a good neonatal outcomes, maternal clinical condition should select the appropriate surgical approach, and effort to reduce cesarean section rates.

Measurement of serum Fe concentration and its physiologic variation were carried out in 240 cases with sensorineural deafness and 60 healthy subjects.The mean value and standard deviation of serum Fe concentration was 148.17?37. 64?g/dl in normal individual and 115.19?16.98?g/dl in the patients with senso-rineural deafness.The difference in serum Fe concentration between the above two groups was highly significant statistically(p

Multiple myeloma (MM) is a largely incurable B-cell hematologic malignancy. Although some patients treated with traditional therapies, such as chemotherapy and radiotherapy,can enter a remission,the disease remains incurable. One of the biggest improvements in the treatment of MM is the use of high-dose chemotherapy followed by stem cell transplantation, which have resulted in an improved remission rate, diseasefree survival and overall survival.

About 40 % of testicular germ-cell tumours are seminomas, and most of them are clinical stage Ⅰ . For a long time, the standard treatment approach for stage Ⅰ testicular seminoma has been radical inguinal orchiectomy followed by radiotherapy to the para-aortic and ipsilateral pelvic lymph nodes. In recent years, many oncologists indicate that the effect of the adjuvant postoperative para-ortic lymph nodal irradiation and chemotherapy using carboplatin is equivalent to para-aortic and ipsilateral pelvic irradiation post orchiectomy for patients with Stage Ⅰ seminoma of the testis, and the side effects is obviously declined, but the long-term side effects are still indefinite. This review presents the treatment development of the stage Ⅰ testicular seminoma after radical inguinal orchiectomy.

Objective To study MRI and CT manifestations and characteristics of primary intracranial lymphoma,and improve the diagnosis and differential diagnosis.Methods Imaging features of primary intracranial lymphoma in 1 1 patients proved by pathology were analyzed retrospectively.Results 9 cases were solitary tumor and 2 cases multiple lesions.Tumors were located in the frontal lobe in 2 cases,the corpus callosum 2 cases,near meningeal 2 cases,the occipital lobe 3 cases.Tumors presented as isodensity or slight hyper density on CT and equal or slight long T1 and T2 signal on MRI.All the lesions were found with obvious homogenous en-hancement;in which 2 cases were found meningeal strengthened;1 case room tube film strengthened.There were slight space occup-ing effect,mostly mild to moderate edema,severe edema in 2 cases.7 typical cases presented “umbilicus sign”,“notch sign”,“lobu-lated”,“incision sign (fist sign)”,and “half month”and so on.Conclusion Imaging manifestations of primary intracranial lymphoma has certain specificity and MRI plays an important role in making accurate diagnosis in the position and qualitative diagnosis.

Haemophilus influenzae (Hi)is an important human pathogen that causes severe infections inclu-ding meningitis,bacteremic pneumonia and sepsis,mostly affecting young children.The resistance of Hi to antimicro-bials has risen and wide variations exist in antibiotic resistance,both geographically and over time.The main mecha-nisms of resistance of Hi are those to β-lactam antibiotics.Antibiotic utilization is the main risk factors for the deve-lopment of antimicrobial resistance.Third -generation cephalosporins is the most effective antibiotic agent to treat the infections of Hi in children population.With continued research,progress toward a broadly effective vaccine to prevent infections caused by Hi is expected in the near future.

Objective To investigate the effect and safety of oxcarbazepine adjunctive therapy in the treat-ment of adults with partial seizures with intractable epilepsy .Methods 76 patients with refractory partial-onset epi-lepsy were selected as research subjects .Patients remained the unchanged antiepileptic drugs in the past ,based on the use of this treatment ,oxcarbazepine was administered in the observation period of one year .The self-controlled open-label study was used to observe the therapeutic effect of the treatment program , retention rate , adverse events , and security.Results 69 patients were followed up for 12 months,the retention rate was 90.79%,the total effective rate was 44.93%,and compared with before treatment ,the total frequency decreased 42.11%(χ2 =36.810,P=0.000), the incidence of SPS(pure partial onset seizures) decreased 42.32%(χ2 =7.864,P=0.046),the incidence of CPS (complex partial seizures) decreased 39.67%(χ2 =7.872,P=0.047),the incidence of SGS(partial seizures,gen-eralized seizures following epilepsy ) decrease 41.96%,(χ2 =7.869,P=0.047).34 cases(49.28%) occurred adverse reactions, including drowsiness 5 cases ( 14.71%), dizziness 3 cases ( 8.82%), headache 13 cases (38.26%),nausea 6 cases(17.65%),inattention 2 cases(5.88%),fatigue 5 cases(14.71%).The adverse reac-tions were mild to moderate ,and were spontaneously relieved or subsided without specific clinical treatment or after stopping treatment .Conclusion Oxcarbazepine in the treatment of adults with refractory partial-onset epilepsy has significant treatment effect ,it is safe,well tolerated,which is worthy of widely used in clinical .

OBJECTIVE: To investigate the anti-tumor activity of adriamycin-loaded chitosan nanoparticles surface-modified with glycyrrhizin on human hepatoma cell line SMMC-7721. METHODS: Inhibition effect of drug-loaded nanoparticle on the proliferation of SMMC-7721 cells was determined with MTT method. Intra-cellular distribution of nanoparticles and morphological change of SMMC-7721 cells before and after treatment were observed by confocal laser scanning microscope (CLSM) and the apoptosis induced by adriamycin was measured by TUNEL assay. RESULTS: The inhibition effect of adriamycin-loaded chitosan nanoparticles surface-modified with glycyrrhizin on the proliferation of SMMC-7721 cells increased 6.36 times lower in comparison with free drugs. The inhibition effect of adriamycin-loaded chitosan nanoparticles had no obvious improvement. Nanoparticles surface-modified with glycyrrhizin promoted the distrubition of adriamycin in the nucleus, so as to promote the anti-tumor activity of adriamycin. TUNEL assay indicated that nanoparticles surface-modified with glycyrrhizin induce DNA fragmentation and nucleus breakdown to induce the apoptosis of SMMC-7721 cells. CONCLUSION: Adriamycin-loaded chitosan nanoparticles surface-modified with glycyrrhizin can used as potential active hepatocyte-targeted delivery carrier. Pharmacokinetic evaluation of it is worthy of further studing.