Objective To explore the relationship between 24 h ambulatory blood pressure monitoring (24h-ABPM) parameters, circadian rhythm and urinary albumin to creatinine ratio (UACR), urineβ2 microglobulin (β2-MG) in elderly patients with hypertension. Methods One hundred and forty-eight patients with essential hypertension (≥60 years old) were included in this study. 24h-ABPM was performed, and nocturnal blood pressure decline rate (BPR) was calculated. The patients were divided into two groups according the BPR:dipper group with 40 cases and non-dipper group with 108 cases. The levels of 24h-ABPM parameters, UACR and β2-MG were compared between two groups, and the relationship between UACR and 24h-ABPM parameters were analyzed. Results The levels of 24hSBP, dSBP and 24hDBP in two groups had no significant differences (P>0.05). Compared with those in dipper group, the levels of nSBP, nDBP in non-dipper group were significantly increased, and the level of dDBP was significantly decreased, P<0.01 or <0.05. The level of 24hPP in non-dipper group was significantly higher than that in dipper group (P<0.01). The levels of UACR andβ2-MG in non-dipper group were significantly higher than those in dipper group (P<0.05). The levels of BUN and SCr in two groups had no significant differences (P>0.05). The result of Sspearman analysis showed that UACR had significant correlation with 24hDBP, nDBP, 24hSBP, nSBP and 24hPP (P<0.05 or<0.01). The result of multivariate linear regression analysis showed that UACR was independently correlated with nSBP (P<0.05). Conclusions The abnormal circadian rhythm in elderly hypertensive patients is closely related to early renal damage.

Objective:To explore the changes of sex hormones in children with cryptorchidism of different ages after laparoscopic treatment and the risk factors that affect the timing of surgery, so as to improve the surgical effect of the treatment of children with cryptorchidism.Methods:A total of 80 children with cryptorchidism admitted to our hospital from Jun. 2018 to Aug. 2021 were selected as the study subjects, and all children underwent laparoscopic surgery. Twenty-six children aged 6 to 12 months were included in the younger group, 42 children aged 1 to 2 years were included in the middle age group, and 12 children >2 years old were included in the over-age group. Surgical data of the children were recorded, and the levels of follicle-stimulating hormone (FSH) , Luteinizing hormone (LH) and Testosterone (T) were detected. Logistic analysis was used to analyze the independent risk factors affecting the timing of operation in children with cryptorchidism, and ROC curve analysis was used to analyze the diagnostic value of factors affecting the timing of operation in children with cryptorchidism.Results:The level of T (the younger group (7.36±1.63) vs (7.48±1.67) ng/ml; the middle-age group (7.03±1.26) vs (7.11±1.07) ng/ml; the over-age group (4.81±1.37) vs (4.92±1.63) ng/ml) , occult testicular volume (the younger group (0.30±0.01) vs (0.32±0.03) cm3; the middle-age group (0.45±0.14) vs (0.47±0.11) cm 3; the over-age group (0.45±0.09) vs (0.61±0.08) cm 3) and occult testicular minimum blood flow velocity (the younger group (3.42±0.87) vs (4.26±0.94) cm/s; the middle-age group (3.51±0.26) vs (5.69±0.35) cm/s; the over-age group (8.41±0.34) vs (23.64±0.19) cm/s) increased in all three groups,In terms of intraoperative blood loss, postoperative time to get out of bed, and incision pain time, the over-age group > the middle age group > the younger group; FSH and LH decreased in the young age group and increased in the middle age group and over-age group ( P < 0.05) . Age, family income, primiparas, smoking or passive smoking during pregnancy, gestational diabetes mellitus, and protein supplementation during pregnancy were independent risk factors affecting the timing of surgery in children with untorchidism. The areas under ROC curve were 0.884, 0.704, 0.785, 0.842, 0.904, and 0.845, respectively. The area under ROC curve to evaluate the differentiation was 0.866. Conclusion:The range of sex hormone changes in children with cryptorchidism of different ages after laparoscopic treatment is related to age, family income, primipara, smoking or passive smoking during pregnancy, diabetes mellitus during pregnancy, and no protein supplement during pregnancy are the factors affecting the timing of surgery.