Objective:To investigate the effects of acupoint massage combined with high-frequency repetitive transcranial magnetic stimulation on post-stroke depression and quality of life.Methods:A total of 169 patients with post-stroke depression who were admitted to the Department of Neurological Intensive Care Unit of Zhengzhou University First Affiliated Hospital from June 2017 to June 2019 were selected as the research subjects. The patients were divided into observation group (85 cases) and control group (84 cases) by random number table method. The control group was treated with high frequency repetitive transcranial magnetic stimulation, and the observation group was treated with high frequency repetitive transcranial magnetic stimulation combined with acupoint massage, high frequency repetitive transcranial magnetic stimulation 5 times a week, 28 minutes each time, 8 weeks of intervention, acupoint massage once a day, 1-2 minutes each acupoint, 8 weeks of intervention. The state of depression and the improvement of quality of life were observed, and the adverse reactions were recorded.Results:The total effective rate of depressive symptoms improvement in the observation group was 83.53% (71/85), which was higher than that of the control group 70.24% (59/84), the difference was statistically significant ( χ 2 value was 4.204, P<0.05). After the intervention, the Hamilton Depression (HAMD) scores of both groups decreased, and the trend decreased with time, and the decline of the observation group was higher than that of the control group, the difference was statistically significant ( Ftime value was 888.220, Fgroup value was 191.331, Finteraction value was 14.955, P<0.01 or 0.05). The observation group ′s physiological function, physiological function, energy, social function, general health status, emotional function, and mental health score were (57.25 ± 10.33), (64.41 ± 13.35), (67.26 ± 12.93), (70.43 ± 14.15), (64.64 ± 12.52), (72.71 ± 13.24), (75.24 ± 12.90) points, higher than the control group ′s (51.83 ± 10.22), (55.40 ± 12.90), (62.84 ± 12.81), (66.03 ± 13.94), (59.37 ± 11.26), (67.54 ± 13.07), (70.85 ± 12.66) points, the difference was statistically significant ( t value was 2.036-4.461, P<0.01 or 0.05). There was no significant difference in the incidence of adverse reactions between the two groups ( P > 0.05). Conclusions:Acupoint massage combined with high-frequency repetitive transcranial magnetic stimulation has a effective in the treatment of post-stroke depression, which can significantly improve the depression status and quality of life.