Objective To determine the effects of nitroglycerine on cooling and rewarming during cardiopulmonary bypass with deep hypothermic circulatory arrest (DHCAC).Methods Forty-six patients undergoing total aortic arch replacement with DHCAC, 38 males and 8 females, aged 26-74 years, falling into ASA physical status Ⅳ or Ⅴ, were randomly assigned to study group (n=24) and control group (n=22).The same cooling and rewarming methods were implemented in both groups.During cooling and rewarming, the study group received nitroglycerine infusion and the control group normal saline of same volume.The rectum rewarming time, the nasopharyngeal cooling and rewarming time were measured and compared.Results The time of rewarming rectum was significantly shorter in the study group compared to the control group [(104±30) min vs (127±31) min, P<0.05].There was no difference in cooling time , time of rewarming nasopharynx.Conclusion Nitroglycerine shortens the time of rewarming rectum during cardiopulmonary bypass with deep hypothermic circulatory arrest.

Neonates occupied a large numbers in extracorporeal membrane oxygenation (ECMO) group.Cases of ECMO for neonate diseases increased year by year and the survival rate of patients improved apparently all over the world.But in China,ECMO in newborn diseases is still at the starting stage.ECMO is a feasible resolution for neonates with circulation or respiratory crisis who had no response to all medical treatment except ECMO.But ECMO still has invasive problem,difficulties in anti-coagulation management,high ratio of complication,expensive cost and unsatisfactory survival rates of newborns with some disease.Now,the application of ECMO for neonate diseases at home and abroad was summarized.