1.Relationship between oral and gastric Hp infection and diseases of upper digestive tract in children.
Yun-guang BAO ; Yi WEI ; Ai-su LANG ; Wei-jun YU ; Ai-juan YING ; Lin-qing MU ; Hui-xian YANG
Chinese Journal of Pediatrics 2003;41(6):465-466
Adolescent
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Child
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Child, Preschool
;
Female
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Gastric Mucosa
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microbiology
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Gastrointestinal Diseases
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diagnosis
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microbiology
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Helicobacter Infections
;
diagnosis
;
microbiology
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Helicobacter pylori
;
growth & development
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isolation & purification
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Humans
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Infant
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Male
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Mouth Mucosa
;
microbiology
2.Comparative imaging study for soft tissue changes in osteomyelitis and malignant bone tumor
Ji-Hua LIU ; Yun ZHANG ; Wen-Jian XU ; Yan-Feng SU ; Da-Peng HAO ; Ai-De XU ;
Chinese Journal of Radiology 2001;0(04):-
Objective To investigate the value of the imaging findings of soft tissue abnormality in the differential diagnosis between osteomyelitis and malignant bone tumor.Methods The CT and MRI findings of soft tissue changes in 57 cases of osteomyelitis and 70 cases of malignant bone tumor were retrospectively defined,observed,recorded and statistically analyzed.Results In 57 cases of osteomyelitis, 54 cases were examined with CT,and soft tissue swelling was presented in 52 cases (degree Ⅰin 19 cases, degreeⅡin 16 cases,degree Ⅲin 17 cases).Abscess-like cysts in soft tissue occurred in 6 cases,masses in 5,air in 1,fat-fluid level in 1 and sinus tract in 1.Among 14 cases examined with MR imaging,soft tissue swelling was presented in all cases (degreeⅠin 2 cases,degree Ⅱin 6 cases and degree Ⅲin 6 cases). Abscess-like cysts appeared in 3 cases and showed high signal in diffusion weighted imaging, mass in Ⅰand fat-fluid level in 1.Among 54 cases examined with CT in 70 cases of malignant bone tumor, soft tissue swelling was presented in 44 cases (degreeⅠin 29 cases,degreeⅡin 12 cases,degreeⅢin 3 cases).Soft tissue masses appeared in 49 cases,bone shell and shell-like calcification in 16 cases and neoplastic bone and neoplastic calcified cartilage within soft tissue mass in 25 cases.Among 49 cases examined with MR imaging,soft tissue swelling was presented in 46 cases (degree Ⅰin 21 cases,degreeⅡin 17 cases and degree Ⅲin 8 cases),and soft tissue masses appeared in 43 cases.The degree of soft tissue swelling and the occurrence of abscess-like cyst,mass,bone shell or shell-liked calcification in the rim of mass,neoplastic bone or neoplastic calcified cartilage in masses showed significant difference(P
3.Effects of Modified Qianjin Weijing Decoction on TNF-α and NF-κB in Rats with Lung Injury Induced by Particulate Matter
yun Zhao SHEN ; guang Sheng FU ; dong Ai YANG ; hua Zhong WU ; yun Su LI ; ye Yu SHUAI ; ren Pu TANG
Chinese Journal of Information on Traditional Chinese Medicine 2018;25(1):38-42
Objective To investigate the protective effect of modified Qianjin Weijing Decoction(MQJWJD)on TNF-α and NF-κB in rats with lung injury induced by particulate matter; To discuss relevant mechanism of action. Methods A tracheal drip 15 mg/kg fine particles of saline solution was used to establish modeling, every other day, three times. Thirty-two Wistar rats were randomly divided into normal group, model group and MQJWJD high-dose and low-dose groups, with eight rats in each group. Medication groups were given relevant medicine for gavage. The level of TNF-α in bronchoalveolar lavage fluid (BALF) was measured by ELISA. The expression of NF-κB protein in lung tissues was measured by immunohistochemistry. The histopathology of the lung injury was observed by light microscope. Results Compared with normal group, the level of TNF-α and the expression of NF-κB protein in the model group were higher than those in the normal group (P<0.01). Compared with model group, the level of TNF-α and the expression of NF-κB protein in MQJWJD low-dose and high-dose groups were lower than those in the model group (P<0.05, P<0.01). Pathological observation showed that, compared with normal group, model group showed intratracheal, alveolar and interstitial bacteria within a large number of fine particles calm, alveolar and pulmonary interstitial visible large amounts of phagocytic fine particles of macrophages and accompanied by more neutrophils and lymphocyte infiltration; Lung tissue pathological changes were significantly lighter in MQJWJD high-dose and low-dose groups than the model group. MQJWJD high-dose group showed mild inflammation, alveolar and pulmonary interstitial visible phagocytic fine particles of macrophages, a small amount of neutrophils and lymphocyte infiltration. Conclusion MQJWJD can reduce the pulmonary injury in rats induced by particulate matter and has protective effects on the rat model through decreasing the levels of TNF-α and the expressions of NF-κB protein in injured lung tissues.
4.Removing breast foreign body resulted from augmentation with polyacrylamide hydrogel injection and silicone prosthesis implantation at one stage.
Qing TANG ; Ai-yun SU ; Jian GU ; Gang CHENG ; Xiang-xia LIU ; Guo-zhong YU
Chinese Journal of Plastic Surgery 2006;22(3):183-185
OBJECTIVEThis study was to investigate an operation, in which removing breast cysts of foreign body resulted from augmentation with polyacrylamide hydrogel injection was performed simultaneously with silicone prosthesis implantation under SEPS endoscope in order to relieve tissue injury and increase the accuracy of clearance.
METHODSEight patients were included in this study. Preoperative type B ultrasound examination was performed to mark the mass. Through an axillary approach, the cysts of foreign body that were distributed in the subcutaneous tissue, breast or muscle were separated and ablated under SEPS endoscope. After removal of the foreign body, a silicone implant was located submuscularly for breast augmentation.
RESULTSThe operations were completed without hematoma and infection. Follow-up of the eight patients for 3 to 12 months showed that preoperative symptoms relating to the injected material, such as breast pain, lump and asymmetry, have no longer existed. The shapes of the breasts were satisfactory.
CONCLUSIONSWe believe that endoscope-assisted mammoplasty offers more satisfactory clinical results with less injury, less morbidity, less scars, more accuracy and greater patient acceptance.
Acrylic Resins ; Adult ; Breast Implantation ; methods ; Breast Implants ; Endoscopy ; Female ; Follow-Up Studies ; Foreign Bodies ; Humans ; Mammaplasty ; methods ; Silicone Gels ; Treatment Outcome ; Young Adult
5.Right upper abdominal wall malignant fibrous xanthomas complicated with ileocecal adenocarcinoma and uterine leiomyoma: a case report.
Yu-feng YUAN ; Zi-su LIU ; Qun QIAN ; Bi-cheng WANG ; Yue-ming HE ; Yun-hua WU ; Ke-yan ZHENG ; Cong-qian JIANG ; Zhong-li AI
Chinese Journal of Oncology 2005;27(12):716-716
Abdominal Wall
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Adenocarcinoma
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diagnosis
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Colonic Neoplasms
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diagnosis
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Female
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Histiocytoma, Malignant Fibrous
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diagnosis
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Humans
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Ileal Neoplasms
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diagnosis
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Ileocecal Valve
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Leiomyoma
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diagnosis
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Middle Aged
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Neoplasms, Multiple Primary
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diagnosis
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Soft Tissue Neoplasms
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diagnosis
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Uterine Neoplasms
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diagnosis
6.Clinical analysis of 170 cases head and neck lymphoma.
Yuan-zheng QIU ; Yong-quan TIAN ; Wen-bin AI ; Jian-yun XIAO ; Su-ping ZHAO
Journal of Central South University(Medical Sciences) 2006;31(6):921-924
OBJECTIVE:
To study the characteristics of head and neck lymphoma in order to improve its diagnose rate.
METHODS:
Review and analysis 170 patients with head and neck lymphoma in department of otolaryngology of Xiangya hospital from 1997 to 2005.
RESULTS:
Nasal cavity and nasal sinuses, neck, tonsil were the common place of the origin of head and neck lymphoma. There are 9 cases Hodgkin disease and 161 cases non-Hodgkin lymphoma (NHL). T cellularity, B cellularity lymphoma, the mixed pattern and nullityping accounted for 60.9%, 36.0% and 3.1% of these patients with NHL, respectively. CHOP and radiotherapy were the main treatment method.
CONCLUSION
The clinical and imageology manifestation of head and neck lymphoma were of diversification and no specificity, whose final diagnosis depended on immunohistochemistry.
Adolescent
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Adult
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Aged
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Child
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Child, Preschool
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Female
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Head and Neck Neoplasms
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pathology
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therapy
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Humans
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Infant
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Lymphoma
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pathology
;
therapy
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Male
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Middle Aged
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Retrospective Studies
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Young Adult
7.Analysis of the risk factors causing tracheal stenosis after tracheotomy for mechanical ventilation in 560 patients.
Xuan WU ; Zhen-Zhong SU ; Li-Jing HU ; Ai-Yun JIANG ; Wei-Ping WEN ; Wen-Bin LEI ; Ai-Hua LIN
Chinese Journal of Otorhinolaryngology Head and Neck Surgery 2007;42(11):839-842
OBJECTIVETo investigate the risk factors causing tracheal stenosis after tracheotomy for mechanical ventilation.
METHODSA retrospective study was carried out to review the clinical data of 560 patients who had been tracheotomy for mechanical ventilation in the First Affiliated Hospital of Sun Yat-sen University from 1990 to 2006. The clinical relevant factors causing tracheal stenosis included age, sex, preoperative intubation, preoperative intubation time, postoperative mechanical ventilation duration, airway infection, multiple changes of intubation tube, cricothyroidotomy, previous tracheotomy, gastroesophageal reflux, diabetes, etc. Multivariate stepwise logistic regression model was used for the analysis.
RESULTSFifty-four cases (9.6%) presented tracheal stenosis in 560 patients after tracheotomy. With multivariate analysis, it was confirmed that the following variable correlated to tracheal stenosis. i.e, preoperative intubation time (chi2 = 4.323, P = 0.038), postoperative mechanical ventilation duration (chi2 = 14.062, P = 0.000), airway infection (chi2 = 8.604, P = 0.004), diabetes (chi2 = 5.237, P = 0.014). The effect degree of these risk factors was as below, postoperative mechanical ventilation duration (OR = 10.818), airway infection (OR = 6.349), diabetes (OR = 3.019), intubation time preoperative (OR = 2.156).
CONCLUSIONSAmong patients who received tracheotomy for mechanical ventilation, the clinical relevant factors causing tracheal stenosis were various. Statistical analysis showed that preoperative intubation time, postoperative mechanical ventilation duration, diabetes, airway infection were main risky factors which may cause tracheal stenosis.
Adolescent ; Adult ; Aged ; Aged, 80 and over ; Female ; Humans ; Logistic Models ; Male ; Middle Aged ; Multivariate Analysis ; Respiration, Artificial ; adverse effects ; Retrospective Studies ; Risk Factors ; Tracheal Stenosis ; etiology ; Tracheotomy ; adverse effects ; Young Adult
8.Analysis of relevant factors causing laryngeal stenosis after partial laryngectomy.
Xuan WU ; Zhen-zhong SU ; Ai-yun JIANG ; Ai-hua LIN ; Li-ping CHAI ; Wei-ping WEN ; Wen-bin LEI
Chinese Journal of Otorhinolaryngology Head and Neck Surgery 2005;40(12):929-932
OBJECTIVETo investigate the clinical relevant factors causing laryngeal stenosis after partial laryngectomy.
METHODSA retrospective study was carried out to review the history clinical data from 138 patients of partial laryngectomy in the First Affiliated Hospital of Sun Yat-Sen University between January 1994 to October 2004. The clinical relevant factors causing laryngeal stenosis were included as follows: age, sex, TNM stage, tumor site, extension of thyroid cartilage defect, extension of larynx parenchyma defect, reconstruction method, laryngeal dilator, duration of using antibiotics, postoperative radiotherapy, lung infection, gastroesophageal reflux, diabetes. Multivariate stepwise logistic regression model was used for the analysis.
RESULTSOf 138 cases after partial laryngectomy, stenosis developed in 25 cases. The occurrence rate was 18.1%. In multivariate analysis, it was confirmed that the following factors correlated to laryngeal stenosis, i. e, extension of thyroid cartilage defect (chi2 = 4.323, P = 0.038), postoperative radiotherapy (chi2 = 6.002, P = 0.014), lung infection (chi2 = 4.220, P = 0.040), and gastroesophageal reflux (chi2 = 5.614, P = 0.018).
CONCLUSIONSThe clinical relevant factors causing laryngeal stenosis after partial laryngectomy were multiple. Statistical analysis showed that extension of thyroid cartilage defect, postoperative radiotherapy, lung infection and gastroesophageal reflux were the risk factors which may cause laryngeal stenosis.
Adult ; Aged ; Aged, 80 and over ; Female ; Humans ; Laryngeal Neoplasms ; pathology ; surgery ; Laryngectomy ; adverse effects ; Laryngostenosis ; etiology ; pathology ; Logistic Models ; Male ; Middle Aged ; Neoplasm Staging ; Postoperative Complications ; Retrospective Studies ; Risk Factors
9.Therapeutic limitations and strategies of angiogenesis inhibitors
Wei WANG ; yun Su YU ; wei Jia WU ; Shuai HUANG ; yuan Yuan WU ; xing Wen CHEN ; yun Ai WANG ; Yin LU
Chinese Pharmacological Bulletin 2017;33(11):1489-1492
Angiogenesis inhibitors can make tumor cells in a harsh environment by inhibiting tumor angiogenesis and effectively blocking the tumor progression.However,anti-angiogenic drugs have shown lots of limitations,such as short-term duration,numerous adverse reactions,benefiting only a minority of tumor types and so on.These limitations restrain the development of new drugs and limit the cancer therapies.Many studies have revealed that tumor cells can escape from anti-angiogenic treatments through a variety of ways and mechanisms.In this review,we focus on the reasons behind the failure in treatments,so as to propose solving strategies to improve the current anti-angiogenic drug efficacy and provide reference for new angiogenesis inhibitors and clinical medication.
10.Research progress in role of myeloid cells in tumor microenvironment and its mechanisms
Jia-Wei WU ; Yu-Zhu CAO ; Su-Yun YU ; Ting-Ting ZHANG ; Yu YANG ; Wen-Xing CHEN ; Ai-Yun WANG ; Yin LU
Chinese Pharmacological Bulletin 2018;34(2):149-153
In recent years,a large number of studies have shown that myeloid cells in tumor microenvironment play an important role in tumorigenesis and tumor progression.On one hand,myeloid cells can regulate human immune system;on the other hand,myeloid cells can influence tumor progression,metastasis and clinical treatments.In this review,we summarize the interaction between myeloid cells and tumors,discuss the effects of myeloid cells after recruited to tumor sites and its mechanisms,try to put forward clinical therapy targeting myeloid cells and provide references for the following research and clinical treatments.