No abstract available.
Drug Therapy* ; Neuroectodermal Tumors, Primitive*

No abstract available.
Blepharoplasty*

A 52-year-old man with multiple myeloma developed cutaneous nodules while being treated with melphalan and prednisolone. A biopsy specimen showed dermal infiltration by well differentiated plasma cells similar to those found on bone marrow biopsy. The use of peroxidase anti-peroxidase to demonstrate the monoclonality or polyclonality of the cytomplasmic immunoglohulins in the tumor cells revealed a positivity for IgG and 1 chain (ie, monotypic staining). Ultrastructurally, each plasmacytoma cell contained varyting amounts of rough endoplasmic reticulum and Golgi-apparatus. The cutnneous nodules completely disappeared after radiotherapy
Biopsy ; Bone Marrow ; Endoplasmic Reticulum, Rough ; Humans ; Immunoglobulin G ; Melphalan ; Middle Aged ; Multiple Myeloma* ; Peroxidase ; Plasma Cells ; Plasmacytoma* ; Prednisolone ; Radiotherapy

Progressive cribriform and zosteriform hyperpigmentation (PCZH) is a distinctive clinical entity first described by Rower et al. in 1978. It is characterized by a single area of uniformly tan cribriform macular pigmentation in a zosteriform distriggtjpp with no preceding history of skin rash, injury or inflammation. It begins well after birth with gradual extension and is not associatad with any other cutaneous or internal abnormalities. Histologically, there is a mild increase in melanin pigment in the basal cell layer and complete absence of nevus cells. Recently, we observed clinical and histological featurea of 5 cases of PCZH. The age at onset ranged from 4 to 35 years. The lesions were unilaterally distributed on face, neck, chest, or abdomen. Histologically there was a mild increase in melanin pigment in the basal cell layer. PCZH must be differentiated from Beckers hairy nevus which begins with a unilateral lesion of irregularly macular pigmentation but occasionally it may be multiple or bilateral. In early stage, overgrowth of hairs may be absent but after a few years it is usually present. PCZH is characterized by uniformly tan cribriform pigmentation in zosteriform distribution, which is unilateral and does not cross the midline of the body. Overgrowth of hairs is absent even after a few years. So the lesions of Beckers hairy nevus previously reported, which were unilateral and did not cross the midline of the body and did not show overgrowth of hairs even after a few years, must be called progressive cribriform and zosteriforrn hyperpigmentation.
Abdomen ; Exanthema ; Hair ; Hyperpigmentation ; Inflammation ; Melanins ; Neck ; Nevus ; Parturition ; Pigmentation ; Thorax ; Triacetoneamine-N-Oxyl

No abstract available.
Fertilization in Vitro* ; Gonadotropin-Releasing Hormone*

The authors analysed 196 cases of convulsive disorder in children who were admitted to the pediatric department of Kyunghee Hospital from June 1993. Blood samples were drawn immediately following seizures on arrival. Serum prolactin values were measured by radioimmunoassay. The results obtained were as follows: 1) Mean serum prolactin value was 55.4+/-20.8ng/ml in generalized seizures within 1 hr following seizures, 22.5+/-3.9ng/ml in partial seizures. There was a significant difference between generalized scizures and partial scizures (p<0.05). 2) Mean serum prolactin value was 23.5+/-9.7ng/ml in generalized seizures within 1~3 hrs following seizures, 10.4+/-4.9ng/ml in partial seizures. There was a significant difference between generalized seizures and partial seizures (p<0.05). 3) Mean serum prolactin value was 9.5+/-4.4ng/ml in generalized seizures 3 hrs following seizures, 9.8+/-4.8ng/ml in partial seizures. There was no significant difference between generalized seizures and partial seizures (p>0.05). We found transient hyperprolactinemia following generalized seizures but a little change following gartial seizures. Postictal elevation of serum prolactin may represent a biochemical marker of generalized and partial seizures.
Biomarkers ; Child ; Humans ; Hyperprolactinemia ; Prolactin* ; Radioimmunoassay ; Seizures

Immunosuppressive therapy based on the use of antilymphocyte globulin (ALG) has become standard therapy for patients with splastic anemia who are not eligible for bone marrow transplantation. In this study, T cell subsets before and after ALG therapy, hematologic responses, complications and prognostic factors were analysed. Eleven (42%) out of twenty-six patients treated with ALG showed response, but two patients showed relapse. Most of the response (9 cases) was noticed within 6 months after the initiation of ALG therapy (median: 3 months). The main complications of ALG therapy were fever (91%), thrombocytopenia (86%), neutropenia (63%), and serum sickness (56%). Four patients were died just ALG therapy because of serum sickness (2 cases), intracranial hemorrhage (1 case), and shock (1 case). Short interval from diagnosis to treatment suggested to show good response (P=0.0575), but it was not significant statistically. Lymphocyte subsets were measured in the blood of 23 patients. Helper T/suppressor T cell ratio (T4/T8 ratio) at the initiation of ALG therapy (day 0) was higher significantly in patients who were responded (P=0.0299). The patients who showed above 1.0 of T4/T8 ratio on day 0 might be speculated good response (P=0.032). More difference of T4/T8 ratio between day 14 after ALG therapy and day 0 might show good response (P=0.0673). Then the actuarial probability of survival at 3 years in patients treated with ALG was 77%. Our data suggest that ALG therapy may be used as an alternative treatment to bone marrow transplantation, and T4/T8 ration of peripheral blood at the initiation of therapy may be used as one of the prognostic factors.
Anemia ; Anemia, Aplastic* ; Antilymphocyte Serum* ; Bone Marrow Transplantation ; Child* ; Diagnosis ; Fever ; Humans ; Intracranial Hemorrhages ; Lymphocyte Subsets ; Neutropenia ; Recurrence ; Serum Sickness ; Shock ; T-Lymphocyte Subsets ; Thrombocytopenia

PURPOSE:We performed this study to compare correlation between the indices of insulin resistance using fasting insulin and glucose level and body mass index (BMI), and to determine the clinical usefulness of glucose/insulin ratio (G/I ratio), which is easily available in clinical base. METHODS:Total 119 children with simple obesity, whose BMI is over 95th percentile, were evaluated. We calculated G/I ratio, logInsulin, HOMA-IR, logHOMA-IR, and QUICKI and evaluated their relationship to BMI. RESULTS:Children with high-degree obesity had higher insulin resistance than children with mild to moderate-degree obesity (logInsulin, 1.13+/-.23 vs 1.27+/-.29; logHOMA-IR, 0.46+/-.24 vs 0.61+/-.30; QUICKI, 0.33+/-.03, 0.31+/-.03)(P<0.01), and pubertal children had higher insulin resistance than prepubertal children (G/I ratio, 7.39+/-.07 vs 4.85+/-.29; logInsulin, 1.14+/-.27 vs 1.31+/-.22; logHOMA-IR, 0.47+/-.28 vs 0.65+/-.22; QUICKI, 0.33+/-.03 vs 0.31+/-.02) (P<0.001). BMI had correlation coefficient as -0.436 for QUICKI, -0.432 for G/I ratio, 0.430 for logInsulin, and 0.425 for logHOMA-IR (P=0.000). G/I ratio was well correlated with QUICKI (r=0.901, P=0.000), logHOMA-IR (r=-0.865, P=0.000), and logInsulin (r=0.899, P=0.000). The changes of BMI were correlated with changes of G/I ratio (r=-0.547, P<0.01), QUICKI (r=-0.464, P=0.01), and logHOMA-IR (r=0.429, P<0.05). CONCLUSION: This study revealed that the degree of BMI had statistically significant correlation with insulin resistance, which can be reflected by G/I ratio, logHOMA-IR and QUICKI. G/I ratio was well correlated with logHOMA-IR and QUICKI, which suggests that G/I ratio could be used as an bedside index of insulin resistance. The changes of G/I ratio were more correlated with changes of BMI than those of logHOMA-IR and QUICKI.
Body Mass Index ; Child* ; Fasting ; Glucose ; Humans ; Insulin Resistance* ; Insulin* ; Obesity*

The study was undertaken to clarify any quantitative abnormalities in peripheral blood T lymphocytes and T subsets, mediating cell meliated immunity, and the presence of any relation between the degree of quantitative abnormalities and extent of skin lesions and activity of disease in patients with psoriasis by monoclonal antibodies. The results were as follows. 1. Mean percentages of total and suppressor T lymphocytes in 39 patients with psoriasis are significantly decreased as compared with those in 32 controls. Mean ratio of percentage of helper T lymphocytes to that of suppressor Tlymphocytes in 39 patients with psoriasis are significantly increased as compared with that in 32 controls. 2, As classified into three groups according to extent of skin lesions (E: less than 5% E,: 5-30%, and E,: more than 30%), mean pereentages of total T lymphocytes in E, and E, psoriasis group and those of suppressor T lymphocytes in all three psoriasi., groups are significantly decreased as compared with those in controIs. Mean percentages of helper T lymphor,ytes in L psoriasis group and mean ratios of percentage of helper T lymphocytes to that of suppressor T lymphocytes in E, and E, psoriasis groups are significantly increased as compared with those in controls. 3. Cis classified into three groups according to activity of disease (A,: stationary, A,: active, peripherally spreading and A,: active, small papules spreading), mean percentage of total T lymphocytes in peripheral blood lymphocytes in A, psoriasis group and those of suppressor T lymphocytes in all three psoriasis group are significantly decreased as compared with those in controls. Mean percentages of helper T lymphocytes and mean ratios of percentage if helper T lymphocytes to that of suppressor T lymphocytes in A, and A, psorixsis groups are significantly increased as compared with those in controls. These results clarified that there are quantitative abnormalities in peripheral blood I' lymphocytes and T subsets in patients with psoriasis and the degrees of abnorrnalities are related to extent of skin lesions and activity of disease. The aanorrnalities in peri.pheral blood T lymphocytes and T subsets in patients with psoriasis seem to be attributed to primary defect of suppressor T lymphoytes.
Antibodies* ; Antibodies, Monoclonal ; Humans ; Lymphocytes ; Negotiating ; Psoriasis* ; Skin ; T-Lymphocytes*

Management of the bulbous nasal tip with inadequate projection and drooping is challenging aesthetic plastic surgery. The bulbous nasal tip is influenced by several factors; 1) thick, non-elastic oily skin, 2) soft tissue bulkiness due to supratip fibrous fatty tissue, and 3) a wide intercrural angle or increased interdormal distance. Another common factor among caucasians, hypertrophic alar cartilage, is seen less in orientals. These variable factors can be corrected with various surgical maneuvers for proper tip projection and refined alar shape. All these procedures are performed through open rhinoplasty incision. The fibromuscular fatty tissue on the nasal tip is resected with subdermal tangential excision without violating the detmal blood supply. The proximal part of the lateral crus, dome and the part of medial crus which was isolated from the skin and nasal mucosa are replaced and plicated in midline in the role of a new columellar strut and skeletal support. If more skeletal supports are desired, the new columellar is reinforced with a silicone strut and conchal cartilage onlay grafts are applied. And for lengthening of the columella, a V-Y advancement incision on the columellar base with open rhinoplasty is applied. The pressure splint on the upper third of the columella and nasal tip is applied on the 7th postoperative day and maintained for two months. All procedures are focused on the preservation of catilaginous integrity and in providing skeletal support. We performed nasal tip plasty on the bulbous nasal tip and its simple technique and predictability resulted in improved nasal tip projection and contour.
Adipose Tissue ; Cartilage ; Inlays ; Nasal Mucosa ; Rhinoplasty ; Silicones ; Skin ; Splints ; Surgery, Plastic ; Transplants