1.Immunohistological study of lymph follicles and germinal centers in the politeal lymph nodes of developing mice after injection of mitogen and adjuvant.
Kwang Joon AHN ; Won Kyu LEE ; Hee Kyung AHN
Korean Journal of Anatomy 1992;25(3):274-288
No abstract available.
Animals
;
Germinal Center*
;
Lymph Nodes*
;
Mice*
2.Clinical observation on Reye syndrome according to the onset of age in children.
Kyung Hee KIM ; Baik Hee LEE ; Myung Ik LEE ; Don Hee AHN ; Keun Chan SOHN
Journal of the Korean Pediatric Society 1992;35(6):788-794
No abstract available.
Child*
;
Humans
;
Reye Syndrome*
3.Effects of neuropeptide Y on the motility of rabbit uterine strip.
Hee Sug RYU ; Kyung Eun LEE ; Young Soo AHN
Korean Journal of Obstetrics and Gynecology 1991;34(4):476-487
No abstract available.
Neuropeptide Y*
;
Neuropeptides*
4.Infantile asthma anf egg allergy.
Sung Hee LIM ; Hye Sun LEE ; Young Min AHN
Journal of the Korean Pediatric Society 1992;35(9):1226-1235
No abstract available.
Asthma*
;
Atrial Natriuretic Factor*
;
Egg Hypersensitivity*
;
Ovum*
5.Follow up Study of Outcome in Severe Hyperbilirubinemic Newborns Treated with Exchange Transfusion and Phototherapy.
Byoung Sun AHN ; Hyun Min PARK ; Baeck Hee LEE
Journal of the Korean Child Neurology Society 1999;7(1):96-106
PURPOSE: Cerebral palsy or hearing disability of hyperbilirubinemic complication was reduced by blood exchange transfusion(BET) and phototherapy(PT). But in spite of these treatment, abnormal Auditory Brainstem evoked Response(ABR) finding after BET or PT and neurodevelopmental defect due to chronic bilirubin encephalopathy were observed. So we have studied risk factors and outcome of chronic bilirubin encephalopathy after BET, and treatment of hyperbilirubinemia. METHODS: We have analyzed clinical characteristics, the finding and change of ABR after BET in 17 hyperbilirubinemic neonates, and in 8 hyperbilirubinemic neonates who were treated by phototherapy and 15 normal control neonates. RESULTS: 1) Mean bilirubin concentraion were 27.5+/-4.1mg/dL in BET group and 22.1+/-2.3 mg/dL in PT group. There were no difference of clinical findings between BET and PT group. 2) Change of ABR (1) Wave I loss resulted in 4 neonates, wave III loss in 3 neonates, and wave V loss in 2 neonates in BET group(P<0.05). (2) Wave I peak latency and hearing threshold in BET group were significantly increased more than normal control group(P<0.01). 3) In 10 neonates(58.8%) among 17 BET group, 4 neonates(50%) in 8 PT group were observed abnormal initial ABR finding after jaundice treatment. Age at treatment and duration of jaundice(interval between onset of jaundice and treatment) in abnormal ABR group were significant prolongation compared with normal ABR group(P<0.05). 4) Chronic bilirubin encephalopathy(CBE) was observed in 3 neonates(17.6%) among 17 BET group and showed higher of bilirubin level than normalized group after BET (31.1mg/dL vs 26.6mg/dL), other clinical findings showed no significant differences. CONCLUSION: Bilirubin level was significantly elevated in CBE more than in BET group and duration of jaundice, age at treatment were longer in abnormal ABR group than in normal ABR group. So not only bilirubin level but also duration of jaundice shoud be considered at jaundice treatment, and ABR has a potential utility in detection of acute brain toxicity of bilirubin and follow up evaluation of bilirubin encephalopathy.
Bilirubin
;
Brain
;
Brain Stem
;
Cerebral Palsy
;
Follow-Up Studies*
;
Hearing
;
Humans
;
Hyperbilirubinemia
;
Infant, Newborn*
;
Jaundice
;
Kernicterus
;
Phototherapy*
;
Risk Factors
6.A Case of Ovarian Mullerian Mucinous Papillary Cystadenoma of Borderline Malignancy.
Jong Chan PARK ; Jung Hee AHN ; Kyu Wan LEE
Korean Journal of Gynecologic Oncology and Colposcopy 1993;4(3):79-85
Mullerian Mucinous papillary Cyatadenernas of Borderline tumor(MMBT) is lined by mucinous epithelium of endocervical type and is characterized by papillae architecturally similer to those of serous horderline tumors, It has been described rarely in the literature, Thia case was reported with a brief review of the concerened literatures. It has important clinical and pathological diBerences from mucinous birderline tumors with intestinal differentiation, but has many similatities to mixed epithelial borderline tumora of Mulierian type. Recently, a case of MMBT in a 22 years old woman was experienced at our department. We presented this case with a brief review of literature.
Cystadenoma, Papillary*
;
Epithelium
;
Female
;
Humans
;
Mucins*
;
Young Adult
7.Appropriate management of pediatric facial bone fractures.
Hee Chang AHN ; Sun Woo LEE ; Jeong Cheol KIM
Journal of the Korean Society of Plastic and Reconstructive Surgeons 1998;25(8):1491-1500
There is room for debate in appropriate diagnosis and treatment due to physiological and anatomical differences in pediatric facial bone fractures from that of adult's. The objectives of this article is to analyze for our clinical cases and to suggest the appropriate management of facial bone fracture in children. The study included 56 children who had treatment for the craniofacial fractures form March, 1990 to February, 1998. Their ages ranged from 3 to 15. There were 38 males and 18 females. Physical examination, simple x-rays, ultrasonograms and routine CT scans were used for diagnosis. Materials were classified into 28 nasal bone fractures, 4 nasoethmoidal fractures, 6 orbital fractures, 8 mandible fractures, and 10 zygoma fractures. Patients were treated with conservative treatment in 9 cases, with closed reduction in 28 cases and open reduction only, and 14 patients with open reduction and internal fixation using microplates and screws. 3 patients needed autogenous calvarial bone graft. Plates and screws were removed in postoperative 3-6 months. All patients had successful union of fractured bones without no specific complications, and normal bony growths were noticed during the 7 years follow up. We conclude that surgeons should be careful in diagnosis and management for the pediatric facial fracture due to anatomical variations and differences in fracture aspects. First, it is mandatory for surgeous to get accurate diagnosis and identify children's fracture and displacement through routine CT check up along with physical examination. Second, it is important to perform the minimally invasive technique or conservative treatment for the children with mild displacement so that it reduces the incidence of growth retardation which may be caused by extensive operation. However, application of rigid fixation is necessary in case of extensive bony displacement or bony defects because of poor coorporation in postoperative care. Third, plates and screws which were used for the internal fixation should be removed at 3-6 months after the surgery. Fourth, if bone graft is needed, it is better to use autogenous graft than allogeneous graft. Fifth, care for dentition and follow up for growth are necessary for growing children.
Child
;
Dentition
;
Diagnosis
;
Facial Bones*
;
Female
;
Follow-Up Studies
;
Humans
;
Incidence
;
Male
;
Mandible
;
Nasal Bone
;
Orbital Fractures
;
Physical Examination
;
Postoperative Care
;
Tomography, X-Ray Computed
;
Transplants
;
Ultrasonography
;
Zygoma
8.Middle School Students' Addicted Use of Celluar Phone and their Psychosocial Characteristics.
Hyun Kyung SON ; Suk Hee AHN ; Hae Jung LEE
Journal of Korean Academy of Community Health Nursing 2006;17(4):552-562
No abstract available.
Anxiety
;
Cellular Phone
;
Humans
;
Impulsive Behavior
9.Middle School Students' Addicted Use of Celluar Phone and their Psychosocial Characteristics.
Hyun Kyung SON ; Suk Hee AHN ; Hae Jung LEE
Journal of Korean Academy of Community Health Nursing 2006;17(4):552-562
No abstract available.
Anxiety
;
Cellular Phone
;
Humans
;
Impulsive Behavior
10.An Immunohistochemical Study of p53 and RB Protein Expression in Normal Cervical Tissue, Cervical Intraepithelial Neoplasia and Invasive Cervical Carcinoma.
Chan LEE ; Tae Won SUNWOO ; Hee Jung AHN
Korean Journal of Obstetrics and Gynecology 1998;41(9):2295-2303
Carcinoma of the uterine cervix is the most common malignant tumor in Korean women. It is well known that carcinogenesis is a multi-step event involoving the inactivation of tumor supressor genes, such as p53 gene and RB gene. The inactivation of the normal functions of the tumor-suppressor proteins pRB and p53 are important steps in human cervical carcinogenesis, either by mutation or from complex formation with the HPV E6 and E7 oncoproteins. The pRB protein regulates early cell cyle progression by controlling transit through the G1 phase of the cell cyle. The p53 tumor suppressor gene product also plays a role in cell cycle control by the transcriptional regulation of cyclin-CDK inhibitor. Cervical carcinoma is an excellent model for studying the stepwise progression of cell transformation because this is reflected morphologically by the increasing dysplasia of the squamous cells before it becomes and invasive squamous cell carcinoma. The aim of this study was to examine the expression of pRB and compared that with overexpression of p53 in a series of cervical lesions including normal tissuess, dysplasias, carcinoma in situ and carcinomas by immunohistochemical staining with monoclonal antibody to elucidate the role of these tumor suppressor genes. The result were as follows: 1. In normal cervical mucosa and CIN I , a few positively stained cells for pRB were seen in basal and parabasal layer. 2. An abnormality of pRB, loss of expression was seen in 23.8% of CIN III and in 10.8% of invasive carcinoma. 3. Overexpression of p53 was demonstrated in 14.3% of CIN III and in 59.5% of invasive carcinoma. 4. The immunoreactivity of p53 was significantly increased (p<0.05) in stage II, III than stage I , whereas downregulation of pRB and tumor stage was not correlated. 5. The immunoreactivity of p53 was significantly increased (p<0.05) in squamous cell carcinoma than in adenocarcinoma, adenosquamous carcinoma and CIN III. These result suggest that an alteration of pRB is more frequently implicated in CIN III than invasive carcinoma, whereas overexpression of p53 may be involevd in late progression of uterine cervical carcinoma.
Adenocarcinoma
;
Carcinogenesis
;
Carcinoma in Situ
;
Carcinoma, Adenosquamous
;
Carcinoma, Squamous Cell
;
Cell Cycle Checkpoints
;
Cervical Intraepithelial Neoplasia*
;
Cervix Uteri
;
Down-Regulation
;
Female
;
G1 Phase
;
Genes, p53
;
Genes, Retinoblastoma
;
Genes, Tumor Suppressor
;
Humans
;
Mucous Membrane
;
Oncogene Proteins
;
Retinoblastoma Protein*