No abstract available.
Humans ; Infant* ; Infant, Very Low Birth Weight*

Prediction of fluid responsiveness has been considered an essential tool for modern fluid management. However, most studies in this field have focused on patients in intensive care unit despite numerous research throughout several decades. Therefore, the present narrative review aims to show the representative method’s feasibility, advantages, and limitations in predicting fluid responsiveness, focusing on the operating room environments. Firstly, we described the predictors of fluid responsiveness based on heart-lung interaction, including pulse pressure and stroke volume variations, the measurement of respiratory variations of inferior vena cava diameter, and the end-expiratory occlusion test and addressed their limitations. Subsequently, the passive leg raising test and mini-fluid challenge tests were also mentioned, which assess fluid responsiveness by mimicking a classic fluid challenge. In the last part of this review, we pointed out the pitfalls of fluid management based on fluid responsiveness prediction, which emphasized the importance of individualized decision-making. Understanding the available representative methods to predict fluid responsiveness and their associated benefits and drawbacks through this review will aid anesthesiologists in choosing the most reliable methods for optimal fluid administration in each patient during anesthesia in the operating room.

STATEMENT OF PROBLEM: Translucency and masking effect of provisional crown and fixed partial denture materials is an important esthetic consideration. But, provisional resin materials differ substantially in their ability to mask underlying colors. PURPOSE: The purpose of this study was to evaluate the translucency differences of provisional resin materials at various thicknesses and the correlation between the translucency and the masking efficiency. MATERIAL AND METHODS: Two polymethyl methacrylate resins (Jet Tooth Shade, Alike) and three resin composites (Protemp 3 Garant, Luxatemp and Revotek LC) were used. Specimens (n=6) were fabricated from each material in 0.3, 0.5, 0.8, 1.0, 1.5, 2.0 and 3.0 mm thickness. The CIELAB parameters of each specimens were measured using a spectrophotometer. The translucency parameter (TP) values and the masking effect (delta ME*(ab)) values were computed and all data were statistically analyzed by one-way ANOVA and the multiple comparisons Scheffe test. The correlation between the thickness and the TP values and the correlation between the thickness and the delta ME*(ab) values were also evaluated by correlation analysis and regression analysis. RESULTS: The TP values and the delta ME*(ab) values were significantly related to the thickness in all specimens. The TP values were more sensitive to the change of thickness than the delta ME*(ab) values. The order of the translucency by brand was different from the order of the masking effect by brand in all thickness groups. CONCLUSION: Within the limitations of this study, the translucency and masking effect of the provisional resin materials investigated were significantly related to their thickness. The masking effect of provisional resin was correlated with the translucency parameter, but the order of the masking effect by brand was different from the order of the translucency parameter.
Crowns* ; Denture, Partial, Fixed* ; Masks* ; Polymethyl Methacrylate ; Tooth

Statement of problem. Although many studies have been carried out to investigate the correlation between the degree of conversion and the flexural strength of composite resins, there is minimal information in the literature attempting to compare degree of conversion, flexural strength and their correlation between restorative composite resins and flowable composite resins. Purpose. The purposes of this study were to measure the degree of conversion and flexural strength of composite resins with different rheological behavior and to correlate the two properties. Materials and methods. Four restorative (Vit-l-escence, Z-250, Tetric ceram, Esthet-X) and four flowable (Aeliteflo, Admiraflow, Permaflo, Revolution) light-curing composite resins were investigated. The degree of conversion(DC) was analyzed with Fourier transfer infra-red spectroscopy(FTIR) spectrum by a potassium bromide(KBr) pellet transmission method. The spectrum of the unpolymerized specimen had been measured before the specimen was irradiated for 60s with a visible light curing unit. The polymerized specimen was scanned for its FTIR spectrum. The flexural strength(FS) was measured with 3-point bending test according to ISO 4049 after storage in water at 37 degree C for 24 hours. The data were statistically analyzed by an independent sample t-test and one-way ANOVA at the significance level of 0.05. The dependence of flexural strength on the degree of conversion was also analyzed by regression analysis. Results. Mean DC and FS values ranged from 43% to 61% and from 84.7MPa to 156.7MPa respectively. DC values of the flowable composite resins were significantly higher than those of restorative composite resins (P < 0.05). The FS values of restorative composite resins were greater than those of flowable composite resins. No statistically significant correlation was observed between the DC and the FS tested in any of the composites. The dependence of FS on DC in restorative or flowable composite resins was not significant. Conclusion. It can be concluded that radical polymerization of the organic matrix is not a major factor in determining flexural strength of the commercially available composite resins.
Composite Resins* ; Light ; Polymerization ; Polymers ; Potassium ; Spectroscopy, Fourier Transform Infrared ; Water

PURPOSE: This study was done to identify the changes of cognitive function and depression following Chemotherapy in women with breast cancer. METHODS: Fifty patients participated in the study and completed the questionnaire at three-time points: pre-chemotherapy, post-chemotherapy, and six months after the completion of chemotherapy. The assessment tools were: everyday cognition, the Montreal Cognitive Assessment, and the Hospital Anxiety and Depression Scale. Data were analyzed using descriptive statistics and repeated measures analysis of variance. RESULTS: Immediately after chemotherapy, 52.0% of patients complained of subjective cognitive decline and reported greater difficulty in the cognitive domains of attention, memory, and visuospatial abilities. At six-month follow-up, 24.0% of patients exhibited mild cognitive decline. Repeated measures ANOVA showed a significant decline in cognitive function after chemotherapy. However, improvement was observed 6 months after the completion of chemotherapy. Depression showed similar patterns to cognitive function. Higher cognitive decline scores were significantly correlated with higher depression (r=.33, p=.020). CONCLUSION: These results suggest that chemotherapy is highly associated with cognitive decline and depression in women with breast cancer. Nursing intervention is needed to relieve depression as well as cognitive decline in patients undergoing chemotherapy.
Anxiety ; Breast Neoplasms* ; Breast* ; Cognition* ; Depression* ; Drug Therapy* ; Female ; Follow-Up Studies ; Humans ; Longitudinal Studies ; Memory ; Nursing ; Prospective Studies*

PURPOSE: To compare the sensitivity and staging accuracy of dynamically enhanced MR imaging(hereafter, DEI)and turbo spin-echo(TSE) T2-weighted imaging(hereafter, T2WI) in cases of cervical carcinoma. MATERIALS AND METHODS: MR images(T2WI and DEI) of 25 cervical carcinoma patients, diagnosed during surgery, were reviewed by tworadiologists. T2WI employed the TSE technique; dynamic MR imaging, the FLASH technique in the axial plane. DEimages were obtained immediately and at 30, 60, 120, and 180 seconds after rapid injection of Gd-DTPA. The degreeof visualization of the tumor, and its invasiveness, were graded as good, fair, or poor. By correlating thehistopathologic results, the accuracy of the two MR imaging techniques was compared. RESULTS: For tumorvisualization, T2WI was good in 13/25 cases (52%), fair in 3/25(12%), and poor in 9/25(36%); DEI was good in5/25(20%), fair in 7/25(28%), and poor in 13/25 cases (52%). CONCLUSION: For the detection and staging of cervicalcarcinoma, T2WI is superior to DEI. For the diagnosis and staging of cervical carcinoma, DEI is thereforeunnecessary.
Diagnosis* ; Gadolinium DTPA ; Humans ; Magnetic Resonance Imaging* ; Uterine Cervical Neoplasms*

Behcet's disease (BD) is a systemic vasculitis of unknown etiology that is rarely observed in association with leukemia and other hematologic disorders. We recently encountered a patient who presented with BD associated with myelofibrosis that was not attributable to other underlying causes. The patient was a 49-year-old man with a 3-year history of probable BD diagnosed by clinical findings; he was admitted because of anemia and splenomegaly. Bone marrow examination revealed myelofibrosis. After steroid therapy, the patient's symptoms of BD improved, and his hemoglobin level recovered. Therefore, we believe that the patient had BD with bone marrow involvement.
Anemia ; Bone Marrow ; Bone Marrow Examination ; Hemoglobins ; Humans ; Leukemia ; Middle Aged ; Primary Myelofibrosis ; Splenomegaly ; Systemic Vasculitis

PURPOSE: Many different scoring systems have been proposed for assessing the severity of atopic dermatitis. The SCORAD (SCORing Atopic Dermatitis) is one of the best validated systems, but is too complicated and time-consuming for routine clinical use. The aim of this study is to evaluate the Three Item Severity (TIS) score in routine clinical practice and to investigate the correlation with SCORAD and quality of life. METHODS: The study was done on 69 cases of atopic dermatitis randomly selected by SCORAD severity in Kangdong Sacred Heart Hospital pediatric allergy clinic from March 2003 to August 2003. Patients were from three months old to 15 years old. A trained pediatrician assessed the TIS score and simultaneous 10 item questionnaire about quality of life (QOL) was checked. RESULTS: According to the SCORAD, there were 21 (30.4%) mild cases, 26 (37.7%) moderate cases and 22 (31.9%) severe cases out of total 69 patients. According to the TIS score, 21 (30.4%) cases were 0-2 point, 16 (23.2%) were 3 point, 11 (16.0%) were 4-5 point and include 21 (30.3%) were 6-9 point. In QOL score, 21-30 points were most common (36.2%). There was significant positive correlation between TIS score and SCORAD (Spearman's rs= 0.86, P< 0.01). There was significant positive correlation between TIS score and QOL (Spearman's rs=0.89, P< 0.01). CONCLUSION: The TIS score is a reliable and simple scoring system for atopic dermatitis. It is particularly suitable in general practice, for routine clinical use.
Adolescent ; Child* ; Dermatitis, Atopic* ; General Practice ; Heart ; Humans ; Hypersensitivity ; Quality of Life ; Surveys and Questionnaires

There is growing evidence of poor health-related quality of life (HRQOL) in patients with panic disorder (PD). However, little is known about the factors affecting HRQOL in patients with PD. The authors examined whether 5-HTTLPR tri-allelic approach and Cathechol-O-methyltransferase (COMT) Val(158)Met polymorphism can predict HRQOL in patients with PD controlling for sociodemographic factors and disorder-related symptom levels. The sample consisted of 179 patients with PD consecutively recruited from an outpatient clinic and age- and gender ratio-matched 110 healthy controls. The SF-36 was used to assess multiple domains of HRQOL. Hierarchical multiple regression analysis was performed to determine the independent effect of the 5-HTTLPR and COMT Val(158)Met on the SF-36 in panic patients. Patients with PD showed lowered HRQOL in all sub-domains of the SF-36 compared to healthy controls. The 5-HTTLPR independently and additively accounted for 2.2% of variation (6.7% of inherited variance) of perceived general health and the COMT Val(158)Met independently and additively accounted for 1.5% of variation (5.0% of inherited variance) of role limitation due to emotional problems in patient group. The present study suggests that specific genetic polymorphisms are associated with certain domains of HRQOL and provides a new insight on exploring the factors that predict HRQOL in patients with PD.
Adult ; Age Factors ; Alleles ; Case-Control Studies ; Catechol O-Methyltransferase/*genetics ; Female ; Genotype ; Humans ; Male ; Middle Aged ; Panic Disorder/genetics/*pathology ; Polymorphism, Single Nucleotide ; *Quality of Life ; Regression Analysis ; Serotonin Plasma Membrane Transport Proteins/*genetics ; Sex Factors

The neuropeptide substance P(SP) has been implicated in the mediation of inflammation and immune-mediated disease such as arthritis. Recently, it was reported that SP was markedly increased around the blood vessels in inflamed gingiva as well as in close association with the inflammatory cell infiltrate. These results support that SP may contribute to the pathophysiology of neuronal inflammation in human periodontal tissues. SP may regulate inflammatory/immune responses by stimulating the proliferation of human T cells, differentiation and antibody-secreting potential of B cells, macrophage respiratory burst, connective tissue proliferation, and the secretion of cytokines from monocytes and T cells. Here, I studied potential role of SP as a costimulatory chemical signal in inflammatory/immune responses, by determining the released proinflammatory cytokines such as MIP-1alpha, IL-1beta, and IL-6 from culture supernatants of homogeneous immune cell lines. Serum free cell supernatants were concentrated with TCA precipitation, fractionated with SDS-PAGE, and subjected into western blot analysis. Among 15 cell lines tested, macrophage/monocyte cell line RAW264.7 and WR19m.1 showed the highest level of induction of MIP-1alphawhen stimulated with LPS. Discrete IL-6 bands with multiple forms of molecular mass were detected from supernatants of B cell lines A20(32kDa), Daudi(32, 35kDa), and SKW6.4(29kDa), which were expressed constitutively. IL-1beta could not be detected by the method of western blot analysis from supernatants of all cell lines tested except RAW264.7, WR19m.1, and erythroid cell line K562 which showed the least amount of IL-1betasecretion. SP 10(-9)M with suboptimal dose of LPS treatment showed synergistic induction of MIP-1alpharelease from RAW264.7 or WR19m.1, and also IL-6 release from A20, but this synergism is not the case in costimulation of RAW264.7 or WR19m.1 with SP 10(-9)M and TPA. Although treatment of T cell line CTLL-R8 with SP 10(-7)M or PHA+TPA induced modest level of MIP-1alpha secretion, synergism was not observed when they are applied together. These findings all together suggest the possibility of a regulatory role of SP in inflammatory/immune reaction through differential modulation of bioactivities of other chemical cosignals.
Arthritis ; B-Lymphocytes ; Blood Vessels ; Blotting, Western ; Cell Line* ; Chemokine CCL3 ; Connective Tissue ; Cytokines* ; Electrophoresis, Polyacrylamide Gel ; Erythroid Cells ; Gingiva ; Humans ; Inflammation ; Interleukin-6 ; Macrophages ; Monocytes ; Negotiating ; Neurons ; Neuropeptides ; Respiratory Burst ; Substance P* ; T-Lymphocytes