1.Cytotoxicity and Structure Activity Relationship of Dammarane-Type Triterpenoids from the Bark of Aglaia elliptica against P-388 Murine Leukemia Cells.
Ace Tatang HIDAYAT ; Kindi FARABI ; Desi HARNETI ; Rani MAHARANI ; DARWATI ; NURLELASARI ; Tri MAYANTI ; Arlette Suzy SETIAWAN ; Unang SUPRATMAN ; Yoshihito SHIONO
Natural Product Sciences 2017;23(4):291-298
Six dammarane-type triterpenoids, dammar-24-en-3β-ol (1), 3β-epicabraleahydroxy lactone (2), (E)-25-hydroperoxydammar-23-en-3β,20-diol (3), dammar-24-en-3β,20-diol (4), 3β-acetyl-20S,24S-epoxy-25-hydroxydammarane (5), and 3β-epiocotillol (6) were isolated from the methanolic extract of the bark of Aglaia elliptica. The chemical structure were identified on the basis of spectroscopic evidence and by comparison with those spectra previously reported. Compounds 1 – 6 were isolated first time from this plant. Compounds 1 – 6, along with a known synthetic analog, cabraleone (7) were evaluated their cytotoxic activity against P-388 murine leukimia cells in vitro. Among those compounds 3β-acetyl-20S,24S-epoxy-25-hydroxydammarane (5) showed strongest cytotoxic activity with IC₅₀ value of 8.02 ± 0.06 µM.
Aglaia*
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In Vitro Techniques
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Leukemia*
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Meliaceae
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Methanol
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Plants
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Structure-Activity Relationship*
2.Chemical constituents from leaves of Aglaia testicularis.
Feng-Ying CHEN ; Meng-Dan ZHAO
China Journal of Chinese Materia Medica 2013;38(20):3525-3527
To study the chemical constituents from the leaves of Aglaia testicularis. The methanol extract was isolated and purified by silica gel, Sephadex LH-20 and preparative HPLC. Their chemical structures were elucidated by MS and spectral data (1H, 13C-NMR). Seven compounds were isolated from the leaves and identified as dasyclamide (1), aglamide A (2), aglamide B (3), aglamide C (4), aglamide D (5), aglaroxin A 1-O-acetate (6), and 3'-methoxyaglaroxin A 1-0-acetate (7). All compounds were isolated from this plant for the first time.
Aglaia
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chemistry
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Drugs, Chinese Herbal
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chemistry
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isolation & purification
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Molecular Structure
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Plant Leaves
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chemistry
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Spectrometry, Mass, Electrospray Ionization