The study conducted on 58 premature neonate underweight infants at the Department of Resuscitation of the Pediatric Hospital N02 from Febuary 2000 to December 2002 had showed a high mortality of 74.1%. 100% of premature neonate underweight infants under 850g at birth died. The died infant had lower weight at birth, mean arterial blood pH was lower, mean arterial blood PaCO2 was higher. CRIB score had prognostic value to predict the mortality of premature neonate underweight infants using ROC curb and the undercurb superficial zone
Aging, Premature ; Infant Equipment ; Child

Although chronic obstructive pulmonary disease (COPD) is regarded as a chronic inflammatory lung disease, the disease mechanism is still not known. Intriguingly, aging lungs are quite similar to COPD-affected lungs in many ways, and COPD has been viewed as a disease of accelerated premature aging of the lungs. In this paper, based on a literature review, we would like to propose immunosenescence, age-associated decline in immunity, as a critical mechanism for the development of COPD. Immunosenescence can cause a low-grade, systemic inflammation described as inflammaging. This inflammaging may be directly involved in the COPD pathogenesis. The potential contributors to the development of inflammaging in the lungs possibly leading to COPD are discussed in the review paper. A notable fact about COPD is that only 15% to 20% of smokers develop clinically significant COPD. Given that there is a substantial inter-individual variation in inflammaging susceptibility, which is genetically determined and significantly affected by the history of the individual's exposure to pathogens, immunosenescence and inflammaging may also provide the answer for this unexpectedly low susceptibility of smokers to clinically significant COPD.
Aging ; Aging, Premature ; Immunosenescence ; Inflammation ; Lung ; Lung Diseases ; Pulmonary Disease, Chronic Obstructive

Gottron's acrogeria syndrome is a rare genetic disease of unknown etiology with some features suggestive of accelerated aging. The typical clinical presentation consists of premature aging of the skin with atrophy of the cutis and the subcutis. After a brief review of the literature available on this syndrome, we report a case of Gottron s acrogeria syndrome in a 19 year-old man whose right rectus femoris muscle had a fibrotic contracture.
Aging ; Aging, Premature ; Atrophy ; Contracture ; Humans ; Quadriceps Muscle ; Skin ; Young Adult

The symptoms of male sexual dysfunction are somewhat subjective. Although vascular and neurological examinations are used to evaluate sexual function, the results of these examinations are often not consistent with the severity of the symptoms. Consequently, many psychometrically validated assessment tools have been designed solely and specifically to evaluate male sexual dysfunction. They can quantify the subjective symptoms of patients using scoring systems. These recently developed questionnaires assess not only sexual function but also the partner relationship and quality of life. They are also useful for assessing the treatment response. Of the various questionnaires, the International Index of Erectile Function (IIEF), International Index of Erectile Function-5 (IIEF-5), Male Sexual Health Questionnaire (MSHQ), Androgen Deficiency in Aging Males (ADAM), Aging Males' Symptoms (AMS) rating scale, and Premature Ejaculation Diagnostic Tool (PEDT) have been translated into Korean and validated. This study reviews the various questionnaires on male sexual dysfunction and assesses which ones are appropriate for aspects of male sexual dysfunction, such as erectile dysfunction, late-onset hypogonadism, and premature ejaculation.
Aging ; Erectile Dysfunction ; Humans ; Hypogonadism ; Male ; Neurologic Examination ; Premature Ejaculation ; Quality of Life ; Surveys and Questionnaires ; Reproductive Health

BACKGROUND: Redundant and wrinkled face is a common finding in patients with long-standing leprosy, which is responsible for the appearance of premature aging. Chemical peeling plays a role in dermal regeneration in the treatment of wrinkles. However, the effect of chemical peeling has rarely been studied in patients with leprosy. OBJECTIVE: To investigate the effect of chemical peeling on dermal connective tissue components and clinical improvement of facial wrinkles in patients with leprosy. METHODS: Five patients with clinically and bacteriologically inactive lepromatous leprosy were treated with 70% glycolic acid plus 35% trichloroacetic acid (GA-TCA). Histologic and clinical changes were evaluated at 0 and 90 days postpeel. RESULTS: Histologically, collagen fibers and ground substance increased significantly but elastic fibers did not change at 90 days postepeel. Clinically, fine wrinkles improved considerably, whereas most deep wrinkles remained unchanged at day 90. CONCLUSION: This study demonstrates that chemical peeling with GA-TCA, or medium-depth peeling, causes an increase in collagen and ground substance but not in elastic fibers. These changes result in limited clinical improvement in the facial wrinkles of leprosy patients. Therefore, medium-depth chemical peeling may be insufficient to improve the premature aging appearance in patients with leprosy.
Aging, Premature ; Collagen ; Connective Tissue* ; Elastic Tissue ; Humans ; Leprosy* ; Leprosy, Lepromatous ; Regeneration ; Trichloroacetic Acid

We performed penile biothesiometry for determining the penile sensitivity on 56 normal men and 120 patients with primary premature ejaculation (PE) to realize the organic reasons of premature ejaculation. The mean vibration perception threshold at the glans penis and penile shaft was 0.222+/-0.133, 0.124+/-0.046 Microns in normal control, 0.058+/-0.026, 0.055+/-0.023 Microns in patients with PE respectively. The mean vibration perception threshold at the glans penis and penile shaft in patients group showed significantly lower than that of normal controls (P<0.001). The mean vibration perception threshold at the glans penis was higher than that of the penile shaft in normal control, but the mean vibration threshold at the glans penis was as much low as the penile shaft in patients with PE (p<0.001). The vibration perception threshold at the glans penis and penile shaft was increasing with aging in normal men, but in patients with PE, consistently lower values were noted with no increasing tendency with age (p<0.001). The mean vibration perception threshold at the index finger and scrotum was 0.041+/-0.023, 0.334+/-0.184 Microns in normal controls, and 0.039+/-0.023, 0.294+/-0.213 Microns in patients with PE respectively. There were no significant differences between two groups (p>0.05). In conclusion, patients with primary premature ejaculation have a penile hypersensitivity regardless of aging. Penile hypersensitivity may give rise to uncontrolled ejaculation, which is thought to be an organic implication of premature ejaculation."
Aging ; Ejaculation ; Fingers ; Humans ; Hypersensitivity ; Male ; Penis ; Premature Ejaculation* ; Scrotum ; Vibration*

OBJECTIVETo introduce a safe, effective and lasting rhytidectomy technique without destroying the configuration of sideburn.

METHODSThe operation is performed through the coronal incision, the temporal incision that is paralleled to the nasolabial sulcus, and the preauricular incision in the sideburn. Multi-layer dissection of facial tissue is made.

RESULTS46 patients with aging face have been treated using this technique since 2002. All patients obtained good curative effects without any severe complications.

CONCLUSIONSThis operation technique may maintain the natural configuration of the preauricular area and sideburn, result obscure incision scar and avoid harming important nerves or vessels. Multi-layer dissection accords with anatomical principles and produces a lasting curative effect.

Adult ; Aging, Premature ; surgery ; Face ; surgery ; Female ; Follow-Up Studies ; Humans ; Male ; Middle Aged ; Rhytidoplasty ; methods

The branchiogenic anomalies are common congenital cervical anomalies. They usually arise from an incomplete obliteration of the branchial apparatus during fetal development. These anomalies may be confused with and mistaken for other potentially more serious lesions, such as cystic hygromas, teratomas, and lymphomas. The anomalies are typically discovered in the pediatric and adolescent population and develop unilaterally. Bilateral manifestations are very rare and have a familial tendency. In addition, anomalies such as intrauterine and postnasal growth retardation, premature aging and unusual faces may be related with bilateral occurrence. This is the first report in the Korean language literature of bilateral branchial fistulas.
Adolescent ; Aging, Premature ; Branchial Region* ; Fetal Development ; Fistula* ; Humans ; Lymphangioma, Cystic ; Lymphoma ; Teratoma

The sirtuin proteins constitute class III histone deacetylases (HDACs). These evolutionarily conserved NAD(+)-dependent enzymes form an important component in a variety of cellular and biological processes with highly divergent as well as convergent roles in maintaining metabolic homeostasis, safeguarding genomic integrity, regulating cancer metabolism and also inflammatory responses. Amongst the seven known mammalian sirtuin proteins, SIRT1 has gained much attention due to its widely acknowledged roles in promoting longevity and ameliorating age-associated pathologies. The contributions of other sirtuins in the field of aging are also gradually emerging. Here, we summarize some of the recent discoveries in sirtuins biology which clearly implicate the functions of sirtuin proteins in the regulation of premature cellular senescence and accelerated aging. The roles of sirtuins in various cellular processes have been extrapolated to draw inter-linkage with anti-aging mechanisms. Also, the latest findings on sirtuins which might have potential effects in the process of aging have been reviewed.
Aging, Premature ; enzymology ; genetics ; Animals ; Humans ; Longevity ; genetics ; Sirtuin 1 ; genetics ; metabolism

BACKGROUND: Although the aging process and features of chronic obstructive pulmonary disease (COPD) have several similarities, the relationship between aging and COPD pathogenesis remains incompletely understood. The klotho gene was found to be related to premature aging and emphysematous changes in an animal model. We investigated whether klotho gene polymorphisms are related to COPD susceptibility and emphysema severity. METHODS: A total of 219 COPD subjects from the Korean Obstructive Lung Disease Cohort and 305 control subjects were genotyped for two single nucleotide polymorphisms (SNPs) of the klotho gene associated with coronary artery disease. Logistic regression was performed to determine the association of these SNPs with COPD susceptibility and linear regression was performed to investigate their association with emphysema severity in COPD subjects. RESULTS: The mean age of the COPD subjects was 66 years and their mean FEV1 was 1.46 L. There were no associations between either SNP or COPD susceptibility (p=0.6 and 0.2, respectively) and there were no associations with emphysema severity. CONCLUSION: Genetic polymorphisms of the klotho gene were not associated with COPD in a Korean population.
Aging ; Aging, Premature ; Cohort Studies ; Coronary Artery Disease ; Emphysema ; Linear Models ; Logistic Models ; Lung Diseases, Obstructive ; Models, Animal ; Polymorphism, Genetic ; Polymorphism, Single Nucleotide ; Pulmonary Disease, Chronic Obstructive