Aggressive Periodontitis ; diagnosis ; therapy ; Humans

No abstract available.
Aggressive Periodontitis* ; Immunogenetics* ; Immunoglobulin Allotypes ; Immunoglobulin G*

No abstract available.
Aggressive Periodontitis* ; Genotype* ; Humans ; Risk Factors*

Aggressive Periodontitis ; therapy ; Humans ; Periodontics ; methods

The aim of the study was to investigate the effect of surgical therapy combined with the usage of metronidazole gel in the treatment of juvenile periodontitis by comparing clinical indices of flap operation along with application of metronidazole gel and flap operation only. Comparing clinical indices of the baseline, 3 months after surgery, 6 months after surgery statistically, the results are as follows; 1. Bleeding on probing (BOP) was decreased significantly both in the experimental group and the control group at 3 months after surgery (p<0.05). BOP increased 0.9% in the control group 6 months after surgery, while in the experimental group, decreased 4.7% (p>0.05). However, there was no statistically significant difference in these groups (p>0.05). 2. Pocket probing depth (PPD) was decreased significantly both in the experimental group and the control group at 3 months after surgery (p<0.05). PPD increased 0.1mm in the control group 6 months after surgery, while in the experimental group, no increase of the depth could be observed (p>0.05). However, there was no statistically significant difference in these groups (p>0.05). 3. Loss of attachment level(LOA) was decreased significantly both in the experimental group and the control group at 3 months after surgery (p<0.05). LOA increased 0.2mm in the control group 6 months after surgery, while in the experimental group, increased 0.3mm However, there was no statistically significant difference in these groups (p>0.05). In conclusion, flap operation was effective on the treatment of juvenile periodontitis. However, combined therapy of metronidazole gel could not give rise to any significant adjunctive effect on the treatment outcome.
Aggressive Periodontitis* ; Hemorrhage ; Loa ; Metronidazole* ; Treatment Outcome

OBJECTIVETo evaluate the clinical outcome of periodontal initial therapy on the patients with aggressive periodontitis.

METHODSA total of 48 patients with aggressive periodontitis, including 20 patients with localized aggressive periodontitis (LAgP) and 28 patients with generalized aggressive periodontitis (GAgP), were chosen for the study from the patients referred to the Department of Periodontology of the School of Stomatology of China Medical University from September 2006 to December 2008. All subjects were performed periodontal initial therapy. Probing depth (PD), clinical attachment loss (CAL), bleeding index (BI) and tooth mobility were recorded at baseline and 1, 3 and 6 months after initial treatment.

RESULTSAt 1, 3 and 6 months after periodontal initial therapy, there were significant improvements in PD, CAL, BI and tooth mobility of patients with LAgP and GAgP than those in the baseline (P < 0.05). In patients with LAgP, statistical differences were detected in PD and CAL between 1 and 3 months after periodontal initial therapy (P < 0.05). And in patients with GAgP, statistical differences were detected in PD and CAL between 3 and 6 months after therapy (P < 0.05). At 1, 3, and 6 months after therapy, first molars of all patients showed more significant therapeutic effects than central incisors (P < 0.05).

CONCLUSIONPeriodontal initial therapy showed effectiveness in treatment of aggressive periodontitis. In the mid-term, there were differences in therapeutic effect between patients with LAgP and GAgP.

The aim of the study was to see the total IgG and IgG subclass responses against Aa and Pg in the four early onset periodontitis (EOP) subforms or adult periodontitis (AP). 6 patients consisting of 3 patients from subform I (distinctive LJP pattern), 19 from subform II (post-juvenile periodontitis pattern), 16 from subform III ( LJP pattern but rapidly progressing), 24 from age-matched AP (20-40 years of age) have been selected for the measurements of the total IgG and each IgG subclass against to Pg and the IgG subclass against Aa, respectively. The total IgG titers against to Pg of the subforms I & III had a significantly higher values than subforms II and IV (P<0.05). Among the IgG subclasses, only the lgG3 levels were significantly higher in the subform I than the subform IV(P <0.05). Wide ranges of the antibody titers were noted in all of the EOP subforms and the AP. Except for the subform I, which was typical of localized form, the IgG2 subclass levels to Pg gradually became higher in accordance with the subforms II, III and IV. Both of IgG2 and the IgG4 antibody levels of the EOP were significantly higher than those of AP, while other subclasses were not. All of the four IgG subclass levels to Pg were consistently found to be higher in the younger age group around 20. The levels found to be low around the thirties and then gradually became higher at the ages of late thirties. The IgG2 titer to Aa in the subform I was significantly higher than those of any other subforms. Combinations of IgG1+2+4 were the most frequently found to be elevated followed by the IgG4 only, the IgG2 only, the IgG2+4, the IgG2+3+4, and the IgG1 only, in the descending order.
Aggregatibacter actinomycetemcomitans ; Aggressive Periodontitis* ; Chronic Periodontitis ; Humans ; Immunoglobulin G* ; Periodontitis ; Porphyromonas gingivalis

OBJECTIVE: To evaluate the efficacy of occlusal improvement in the labial fixed orthodontic treatment in aggressive periodontitis patients and to explore the relationship between occlusal improvement and inflammation control. METHODS: Twenty-two aggressive periodontitis patients who underwent combined periodontal-orthodontic treatment were included in this study. The patient's photos were matched to the dental models and digital three dimentional models were acquired using 3Shape R700 laser scanner. The occlusal force distribution maps were generated in the OrthoAnalyzer software. The newly established occlusal force distribution score (OFDS) and proximal contact score (PCS) were used to evaluate the occlusal distribution changes before and after labial fixed orthodontic treatment for assessing the effectiveness of orthodontic treatment. The multi-level linear regression analysis was used to explore the relationship between the probing depth changes and OFDS or PCS changes to screen out the favorable orthodontic strategy for inflammation control, which would provide clinical strategy for combined periodontal-orthodontic treatment in aggressive periodontitis patients. RESULTS: At the patient level, OFDS was improved significantly after orthodontic treatment compared with the score before orthodontic treatment (84.5±20.9 vs.105.3±22.6, P <0.001) and PCS was improved significantly after orthodontic treatment compared with the score before orthodontic treatment (68.9±9.1 vs. 83.7±6.3, P <0.001).At the tooth level, the OFDS was significantly increased in the maxillary anterior teeth (P <0.001) while the PCS of the anterior teeth in both maxillary and mandible arches were significantly increased significantly (P <0.01). No significant changes were found in other tooth positions. The multilevel linear regression model showed that no significant correlation was found between age and gender and probing depth decrease (P >0.05). The baseline probing depth,OFDS improvements and PCS improvements (P <0.001) were positively correlated with probing depth decrease. CONCLUSION This study showed that the distribution of occlusal force was more reasonable and the proximal contacts were more ideal in aggressive periodontitis patients. Orthodontic treatment was effective in improving occlusal force distribution by the above two ways. Especially, the OFDS and PCS improvements were both positively correlated with probing depth decrease, indicating that in the combined periodontal-orthodontic treatment for aggressive periodontitis patients, occlusal force distribution and proximal contact should be improved in order to facilitate periodontal improvement.
Aggressive Periodontitis ; Bite Force ; Dental Care ; Humans ; Regression Analysis

PURPOSE: The purpose of this study was to evaluate the improvement of periodontal health of generalized aggressive periodontitis (GAgP) diagnosed patients treated with non-surgical periodontal therapy accompanying systemic antibiotics administration. METHODS: Two patients with GAgP were chosen for this study. Clinical indices were taken and a radiographic examination was performed at the baseline of the study and they were treated by periodontal therapy accompanying systemic antibiotics administration. Post-surgical visits were scheduled at regular intervals to check clinical and radiographic changes. RESULTS: Through non-surgical periodontal therapy accompanying systemic antibiotics administration, GAgP patients showed decreased probing pocket depth, sulcus bleeding index, and increased attachment level and clinical index when comparing the initial and six month follow up data. In the six month follow-up radiographic examination after non-surgical periodontal therapy, resolution of the bony defect was observed. CONCLUSIONS: Non-surgical therapy combined with systemic antibiotics administration in GAgP patients is suggested to be an effective approach to enhance the periodontal health.
Aggressive Periodontitis ; Anti-Bacterial Agents ; Follow-Up Studies ; Hemorrhage ; Humans ; Periodontitis

PURPOSE: Aggressive periodontitis, especially in its severe form, was traditionally considered to have an unfavourable prognosis. It required a complex treatment and its stabilization was often achieved by surgical therapy. The aim of this study was to investigate the results of nonsurgical periodontal treatment in severe generalized forms of aggressive periodontitis. METHODS: Patients with advanced generalized aggressive periodontitis were included in the study. Probing depth (PD) of pockets > or =7 mm and clinical attachment level (CAL) of sites with attachment loss > or =5 mm were measured at baseline before nonsurgical periodontal treatment, at re-evaluation, and after treatment. The following other parameters were recorded: resolution of inflammation and bone fill. We compared the baseline values with re-evaluation and posttreatment values using the Friedman test. The Wilcoxon test with the Bonferroni correction was used for both re-evaluation and posttreatment values. RESULTS: Seven patients with 266 periodontal sites were examined. A significant difference was found between values, reported as medians with interquartile ranges, for PD at baseline (7.94 [7.33-8.19] mm) and both re-evaluation (4.33 [3.63-5.08] mm) and posttreatment (3.54 [3.33-4.11] mm) values (P=0.002). A significant difference was also found between values for CAL at baseline (9.02 [7.5-9.2] mm) and both re-evaluation (6.55 [6.30-6.87] mm) and posttreatment (6.45 [5.70-6.61] mm) (P=0.002). Inflammation was resolved and angular bone defects were repaired in all cases. CONCLUSIONS: These therapeutic results suggest that this form of periodontitis could have positive outcomes after nonsurgical periodontal treatment. The reparative potential of tissue affected by severe aggressive periodontitis should encourage clinicians to save apparently hopeless teeth in cases of this form of periodontitis.
Aggressive Periodontitis* ; Humans ; Inflammation ; Periodontal Debridement ; Periodontitis ; Prognosis ; Tooth ; Treatment Outcome