1.Informational Needs of Postoperative Gastric Cancer Patients.
Ae Ran KIM ; Min Gew CHOI ; Jae Hyung NOH ; Tae Sung SOHN ; Jae Moon BAE ; Sung KIM
Journal of the Korean Gastric Cancer Association 2009;9(3):117-127
PURPOSE: Adequate health-related information provided by health professionals may help cancer patients overcome their uncertain situation and manage their healthcare. To provide information effectively, there is a need to understand the content of the patients' essential information. The purpose of this study was to identify recent informational needs of postoperative gastric cancer patients. MATERIALS AND METHODS: Data were collected from 190 postoperative gastric cancer patients who attended the Stomach Cancer Patients' Day ceremony (18 November 2008) held by the Stomach Cancer Center of Samsung Medical Center with the use of a questionnaire which measured informational needs. A questionnaire with 37 items was comprised of domains of diagnostic tests, cancer therapy, prognosis, follow-up, sexual activity, stomach cancer-related information, and 7 single items. RESULTS: The priorities of informational needs were the domains of prognosis, ways of healthcare during treatment (a single item), follow-up, stomach cancer-related information, cancer therapy, and diagnostic tests (in descending order). Items related to prognosis, diet, and management of their healthcare ranked in the top 10 informational need scores. As age decreased, the degree of informational needs about diagnostic tests, cancer therapy, sexual activity, and stomach cancer-related information increased. CONCLUSION: We suggest that prognosis-related information based on the accumulated institutional therapeutic outcomes and objective prognosis data should be incorporated in the current education program. Health professionals should provide comprehensible information content to cancer patients and caregivers and encourage patients to participate in their therapy with a more positive attitude.
Caregivers
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Delivery of Health Care
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Diagnostic Tests, Routine
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Diet
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Follow-Up Studies
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Health Occupations
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Humans
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Prognosis
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Surveys and Questionnaires
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Sexual Behavior
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Stomach
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Stomach Neoplasms
2.Therapeutic Inhibitors against Mutated BRAF and MEK for the Treatment of Metastatic Melanoma
Sunhyo RYU ; Chakyung YOUN ; Ae Ran MOON ; Amanda HOWLAND ; Cheryl A ARMSTRONG ; Peter I SONG
Chonnam Medical Journal 2017;53(3):173-177
Melanoma is one of the most aggressive cancers in the world and is responsible for the majority of skin cancer deaths. Recent advances in the field of immunotherapy using active, adoptive, and antigen-specific therapeutic approaches, have generated the expectation that these technologies have the potential to improve the treatment of advanced malignancies, including melanoma. Treatment options for metastatic melanoma patients have been dramatically improved by the FDA approval of new therapeutic agents including vemurafenib, dabrafenib, and sorafenib. These kinase inhibitors have the potential to work in tandem with MEK, PI3K/AKT, and mTOR to inhibit the activity of melanoma inducing BRAF mutations. This review summarizes the effects of the new therapeutic agents against melanoma and the underlying biology of these BRAF inhibitors.
Biology
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Humans
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Immunotherapy
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Melanoma
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Mitogen-Activated Protein Kinase Kinases
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Phosphotransferases
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Skin Neoplasms
3.Small Bowel Necrosis Associated with Catastrophic Antiphospholipid Syndrome: A Case Report
Hyun Ae LEE ; Seong-Eun KIM ; Do Woung JUNG ; Ju Ran BYEON ; A Reum CHOE ; Chung Hyun TAE ; Chang Mo MOON ; Hye Kyung JUNG ; Ki Nam SHIM ; Sung Ae JUNG
The Korean Journal of Gastroenterology 2021;77(6):294-299
Catastrophic antiphospholipid syndrome is a highly fatal condition characterized by widespread thromboembolism subsequent to a triggering factor (e.g., infection, trauma, and neoplasia) in antiphospholipid antibody-positive patients. This paper reports a case of a 29-year-old male without the underlying disease who developed extensive mesenteric thromboembolism and jejunal necrosis during the treatment for acute enteritis. The patient’s condition was improved with low-molecular-weight heparin and an intravenous Ig treatment with emergency surgery. The serum antiphospholipid (anticardiolipin IgM) and lupus anticoagulant antibody tests showed positive results. Acute infectious enterocolitis is generally considered a mild disease. On the other hand, aggressive evaluation and treatment should be considered if the clinical conditions do not improve and deteriorate rapidly despite appropriate antibiotic treatment because of the possibility of acute immunological complications, such as catastrophic antiphospholipid syndrome.
4.Small Bowel Necrosis Associated with Catastrophic Antiphospholipid Syndrome: A Case Report
Hyun Ae LEE ; Seong-Eun KIM ; Do Woung JUNG ; Ju Ran BYEON ; A Reum CHOE ; Chung Hyun TAE ; Chang Mo MOON ; Hye Kyung JUNG ; Ki Nam SHIM ; Sung Ae JUNG
The Korean Journal of Gastroenterology 2021;77(6):294-299
Catastrophic antiphospholipid syndrome is a highly fatal condition characterized by widespread thromboembolism subsequent to a triggering factor (e.g., infection, trauma, and neoplasia) in antiphospholipid antibody-positive patients. This paper reports a case of a 29-year-old male without the underlying disease who developed extensive mesenteric thromboembolism and jejunal necrosis during the treatment for acute enteritis. The patient’s condition was improved with low-molecular-weight heparin and an intravenous Ig treatment with emergency surgery. The serum antiphospholipid (anticardiolipin IgM) and lupus anticoagulant antibody tests showed positive results. Acute infectious enterocolitis is generally considered a mild disease. On the other hand, aggressive evaluation and treatment should be considered if the clinical conditions do not improve and deteriorate rapidly despite appropriate antibiotic treatment because of the possibility of acute immunological complications, such as catastrophic antiphospholipid syndrome.
5.Chlamydophila pneumoniae enhances secretion of VEGF, TGF-beta and TIMP-1 from human bronchial epithelial cells under Th2 dominant microenvironment.
Chan Sun PARK ; Tae Bum KIM ; Keun Ae MOON ; Yun Jeong BAE ; Hee Ran LEE ; Min Kyoung JANG ; Hee Bom MOON ; You Sook CHO
Allergy, Asthma & Immunology Research 2010;2(1):41-47
PURPOSE: Chlamydophila pneumoniae infection in the airways is thought to be associated with the pathogenesis of asthma, especially in non-atopic severe asthma with irreversible airway obstruction that may be related to airway remodeling. Here, we investigated whether C. pneumoniae infection enhances the secretion of critical chemical mediators for airway remodeling, such as VEGF, TGF-beta, and TIMP-1, in human bronchial epithelial cells (BECs) in a Th2-dominant microenvironment. METHODS: Human bronchial epithelial cells (BEAS-2B cells) were infected with C. pneumoniae strain TW183 and cultured in both a Th1-dominant microenvironment with INF-gamma and a Th2-dominant microenvironment with IL-4 or IL-13 added to the culture medium. The VEGF, TGF-beta, and TIMP-1 levels in the culture supernatants were measured using enzyme-linked immunosorbent assays (ELISA). The activation of NF-kappaB in each experimental condition was determined using an electrophoretic mobility shift assay. RESULTS: Chlamydophila pneumoniae-infected BECs showed enhanced secretion of VEGF, TGF-beta, and TIMP-1 compared with non-infected BECs. The levels of cytokines secreted from BECs were increased more when IL-13 was added to the culture medium. C. pneumoniae-infected BECs also showed increased NF-kappaB activation. CONCLUSIONS: These results suggest that C. pneumoniae plays a role in the pathogenesis of airway remodeling in asthma, revealing a Th2-dominant immune response. Further studies are required to clarify the precise mechanism of C. pneumoniae infection in airway remodeling.
Airway Obstruction
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Airway Remodeling
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Asthma
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Chlamydial Pneumonia
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Chlamydophila
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Chlamydophila pneumoniae
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Cytokines
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Electrophoretic Mobility Shift Assay
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Enzyme-Linked Immunosorbent Assay
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Epithelial Cells
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Humans
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Interleukin-13
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Interleukin-4
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NF-kappa B
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Pneumonia
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Sprains and Strains
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Tissue Inhibitor of Metalloproteinase-1
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Tissue Inhibitor of Metalloproteinases
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Transforming Growth Factor beta
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Vascular Endothelial Growth Factor A
6.Detection of Minimal Residual Disease by IgH gene rearrangement-PCR in Childhood Acute Lymphoblastic Leukemia.
Chan Jeoung PARK ; Mi Chong KIM ; Ae Ran MOON ; Eul Ju SEO ; Hyun Sook CHI ; Jong Jin SEO ; Tae Hyung KIM ; Hyung Nam MOON
Korean Journal of Clinical Pathology 1999;19(2):163-171
BACKGROUND: The IgH gene rearrangement (IgH GR) involving highly specific CDR3 region can be used as a minimal residual disease marker in ALL. The IgH GR-PCR has the advantages of the high positive rate in ALL and the detection of clonal evolution. METHODS: In 30 cases of childhood ALL, the DNA was extracted from the bone marrow aspirates at the diagnosis and during the chemotherapy. The 40 cycle polymerase chain reaction was performed with seven each VH family specific primer and common JH primer. The PCR products were electrophoresed on the agarose gel, and those showing specific bands were electrophoresed on 6M urea 6% polyacrylamide DNA sequencing gel. We compared and analyzed the IgH GR-PCR results, the morphologic diagnosis of the bone marrow and the clinical course. RESULTS: IgH GR was detected in 93.3% (28/30) at the diagnosis and the rest of two cases showed IgH GR during the therapy. IgH GR was detected in all specimens diagnosed as persistence, partial remission and relapse, the 80.0% of hypocellular marrow with persistence of blasts, the 72.7% of hypocellular marrow, and the 59.2% of complete remission. In the complete remission states the patients with IgH GR showed significantly higher relapse rate (26.2%) than those without IgH GR (7.1%) (p=0.019). Number of clones of IgH GR was from one to five. The more number of clones showed the shorter mean survival time (p=0.1172). The usage of VH3 was most frequent (70.0%). IgH GR had been detected average 3.5 months (range 1-12 months) earlier than the morphologic relapse appeared. During the chemotherapy the evolution of IgH GR was observed in the seven cases (23.3%). CONCLUSIONS: The IgH GR-PCR will help the understanding of biological characteristics of leukemic cells, the interpretation of the bone marrow studies after chemotherapy and the plans of further therapy, and can be used as a prognostic indicator in the morphologic complete remission state.
Bone Marrow
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Clonal Evolution
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Clone Cells
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Diagnosis
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DNA
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Drug Therapy
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Gene Rearrangement
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Humans
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Neoplasm, Residual*
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Polymerase Chain Reaction
;
Population Characteristics
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Precursor Cell Lymphoblastic Leukemia-Lymphoma*
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Recurrence
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Sepharose
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Sequence Analysis, DNA
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Survival Rate
;
Urea
7.EEG Revealed That Fragrances Positively Affect Menopausal Symptoms in Mid-life Women
Sun Ae MOON ; Jis ub BAE ; Kwang su KIM ; Si Young CHO ; Gu sang KWON ; Ran LEE ; Seung Ho KO ; Soy eon LIM ; Che il MOON
Experimental Neurobiology 2020;29(5):389-401
During mid-life, women experienced not only physical but also neurological transition. Because of this, many women suffer from physiological and/or psychological menopausal symptoms. Although hormone therapy (HT) was broadly used to alleviate menopausal symptoms, HT showed inconsistent effects in case of psychological symptoms. Moreover, mid-life women’s brains have distinct characteristics than in other periods of life, it is needed to study psychological symptoms in shifted brain network of mid-life women. As an alternative, inhalation of fragrances may alleviate psychological menopausal symptoms. To characterize the alleviation mechanism by fragrances, we tested the effect of fragrances on menopausal symptoms using electroencephalographic (EEG) methods. We hypothesized that fragrance could restore mid-life women’s brain response to stressful situations. We tested six fragrance conditions, including no-odor condition (solvent only) in twenty-eight mid-life women (49.75 years±3.49).Our results showed that fragrances increased alpha power and decreased β/α ratio depending on the severity of menopausal symptoms in a stressful situation. Our study would be helpful in psychological menopausal symptom alleviation as well as fragrance screening for well-being in mid-life.
8.Evaluation of an oral health promotion program for elders based on a cooperation model between public and private sectors.
Hee Yong YI ; Ki Jun YU ; Soo Jin LEE ; Min Ji JEONG ; Su Bin JEONG ; Ae Ran MOON ; Bo Ram MOK ; Yeon Hee SONG
Journal of Korean Academy of Oral Health 2014;38(1):41-49
OBJECTIVES: The purpose of this study was to evaluate the effectiveness of a seniors' oral health promotion program for establishing a cooperation model between public and private sectors. METHODS: This study was carried out targeting the seniors frequenting a community center in the Sosa-gu district of Bucheon-si in the Gyeonggi-do province of South Korea. Data were obtained from self-administered questionnaires or personal interviews with elders after they participated in the oral health promotion program. Their perceived satisfaction with their oral health before and after the oral health program was compared. The data were analyzed by t-tests, ANOVA, paired t-tests, and logistic regression using SPSS to assess the effects of explanatory factors on the seniors' satisfaction of the oral health promotion program. RESULTS: In total, 22.7% of participants had a positive idea about the oral health promotion program before their participation. The mean score of change in and difference of satisfaction with oral health tended to increase in each of the following groups: women, aged 80-84 years, number of permanent teeth, full denture wearers, and those who did not require dentures. Satisfaction notably increased 0.4 points in the group of full denture wearers (P<0.05). Moreover, after 1 month, the satisfaction level of the subjects who participated in the oral health promotion program increased 5.2 times (95% CI, 1.04-25.49) compared to dissatisfaction levels. Ultimately, satisfaction with oral health shows a major impact on the satisfaction with an oral health promotion program. CONCLUSIONS: The subjects who received the oral health promotion program responded very positively, but this program needs overall consideration about work processes and further reliable evaluations.
Dental Restoration Wear
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Dentures
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Female
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Gyeonggi-do
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Humans
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Korea
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Logistic Models
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Oral Health*
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Private Sector*
;
Surveys and Questionnaires
;
Tooth
9.Multidimensional Factors Influencing Burnout in Intensive Care Unit Nurses
Se Ra KIM ; Mi Kyeong JEON ; Jin Hee HWANG ; Ae Ran CHOI ; In Sook KIM ; Mi Kyoung PYON ; Kyoung Eun MOON ; Mun Hee KIM ; Na Ra SHIN ; Soon Haeng LEE
Journal of Korean Clinical Nursing Research 2017;23(1):9-19
PURPOSE: This study aimed to identify multidimensional factors influencing burnout in intensive care unit(ICU) nurses. METHODS: A descriptive cross-sectional design was used. Data were collected during February 2016 from a convenience sample of 222 tertiary hospital ICU nurses and analyzed using t-test, ANOVA, correlation analysis, and multiple regression analysis. RESULTS: Burnout correlated positively with compassion fatigue (CF)(r=.37, p < .001), and negatively with compassion satisfaction (CS)(r=-.66, p < .001). The regression model explained 57% of the variance in burnout. For individual characteristics in the model, perceived health status (β=-.27, p < .001) and gender (β=.14, p=.028) were the most influential factors for ICU nurses' burnout. In the model with added work-related characteristics, nursing environment (β=-.22, p=.001), perceived health status (β=-.20, p=.001), and satisfaction with department (β=-.19, p=.007) were the most influential factors. Finally, for the model with psychological characteristics added, CS (β=-.56, p < .001) and CF (β=.35, p < .001) were the most influential factors. CONCLUSION: Results reveal that most ICU nurses have a moderate level of CF and a moderate to high level of CS and burnout, and that individual, work-related and psychological factors are relevant in ICU nurses' burnout. Programs or interventions to reduce burnout should be developed taking into account these multidimensional factors.
Compassion Fatigue
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Critical Care
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Empathy
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Intensive Care Units
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Nursing
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Personal Satisfaction
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Psychology
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Tertiary Care Centers
10.Clinical outcomes of acute upper gastrointestinal bleeding according to the risk indicated by Glasgow-Blatchford risk score-computed tomography score in the emergency room
Hyun Ae LEE ; Hye-Kyung JUNG ; Tae Oh KIM ; Ju-Ran BYEON ; Eui-Sun JEONG ; Hyun-Ji CHO ; Chung Hyun TAE ; Chang Mo MOON ; Seong-Eun KIM ; Ki-Nam SHIM ; Sung-Ae JUNG
The Korean Journal of Internal Medicine 2022;37(6):1176-1185
Background/Aims:
Acute upper gastrointestinal (UGI) bleeding is a significant emergency situation with a mortality rate of 2% to 10%. Therefore, initial risk stratification is important for proper management. We aimed to evaluate the role of contrast-enhanced multidetector computed tomography (MDCT) for risk stratification in patients with acute UGI bleeding in the emergency room (ER).
Methods:
This retrospective study included patients with UGI bleeding in the ER. Glasgow-Blatchford risk score-computed tomography (GBS-CT) was assessed using a combination of GBS and the MDCT scan scoring system.
Results:
Of the 297 patients with UGI bleeding, 124 (41.8%) underwent abdominal MDCT. Among them, 90.3% were classified as high-risk by GBS, and five patients died (4.0%). Rebleeding occurred in nine patients (7.3%). The high-risk GBS-CT group had significantly higher in-hospital mortality (10.5% in high-risk vs. 1.4% in moderate risk vs. 0% in low-risk, p = 0.049), transfusion amount (p < 0.001), and endoscopic hemostasis (p < 0.001) compared to the moderate- and low-risk groups.
Conclusions
Adding MDCT scans to the existing validated prognosis model when predicting the risk of UGI bleeding in patients in the ER plays a significant role in determining in-hospital mortality, transfusions, and the need for endoscopic hemostasis.