Nonfunctioning carcinoma of adrenal cortex is a rare disease and approximately 120 patients with nonfunctional adrenal cortical carcinoma have been reported in the world literature since first description of Rolienston and Marks in 1898. We report a case of nonfunctioning adrenal cortical carcinoma in a 47-year-old female patient, which was suspected by clinical investigation and confirmed by exploration and microscopic examination.
Adrenal Cortex* ; Adrenocortical Carcinoma ; Female ; Humans ; Middle Aged ; Rare Diseases

Nonfunctioning carcinoma of adrenal cortex is a rare disease and approximately 120 patients with nonfunctional adrenal cortical carcinoma have been reported in the world literature since first description of Rolienston and Marks in 1898. We report a case of nonfunctioning adrenal cortical carcinoma in a 47-year-old female patient, which was suspected by clinical investigation and confirmed by exploration and microscopic examination.
Adrenal Cortex* ; Adrenocortical Carcinoma ; Female ; Humans ; Middle Aged ; Rare Diseases

Nonfunctioning carcinoma of the adrenal cortex is an extremely rare disease. Lewinsky and his associates could review only a total of 178 cases, collected from the literature up to the year 1974, including their 20 additional new cases. We report on a 55-year-old woman with nonfunctioning adrenocortical carcinoma metastasized to the lung.
Adrenal Cortex ; Adrenocortical Carcinoma* ; Female ; Humans ; Lung ; Middle Aged ; Rare Diseases

Nonfunctioning carcinoma of the adrenal cortex is an extremely rare disease. We have presented a case of nonfunctioning adrenocortical carcinoma. The patient was a 35 year-old female who had complained of discomfort and gradually growing mass in the left upper quadran1. No significant laboratory findings or evidence of hormonal disturbance wee clinically noted. Ultrasonography and abdominal CT revealed about 15 x 13cm sized mass in the left suprarenal area. Left adrenal gland. kidney and spleen were removed. The tumor was multilobulated but well encapsulated. measuring 16 x 15 x 13cm in size and weighing 420 grams. Cut surface of the tumor showed massive hemorrhage and necrosis, Microscopically, the tumor showed marked cellular pleomorphism, nuclear hyperchromatism and increased mitoses with some atypical mitoses. Capsular and vascular invasion of tumor cells was observed.
Adrenal Cortex ; Adrenal Glands ; Adrenocortical Carcinoma* ; Adult ; Female ; Hemorrhage ; Humans ; Kidney ; Mitosis ; Necrosis ; Rare Diseases ; Spleen ; Tomography, X-Ray Computed ; Ultrasonography

The identification of fat density by unenhanced CT within an adrenal mass is highly suggestive of myelolipoma. Adrenal collision tumors which involve a myelolipoma are uncommon, though the involvement of adenomas and pheochromocytomas has been reported. We describe a case in which an adrenal collision tumor consisting of an adrenocortical carcinoma and myelolipoma, presented as a large fat-containing adrenal soft tissue mass.
Adenoma ; Adrenocortical Carcinoma* ; Myelolipoma* ; Pheochromocytoma

From September 1980 to November 1989, eight patients with adrenal tumors had been admitted to our Department of Urology, Chonbuk National University hospital. Nine tumors consisted of 5 adrenal adenomas, 2 pheochromocytomas. a neuroblasloma and adrenocortical cancer. A clinicopathological study was made and the results were obtained as follows : 1. The 8 patients in these series included 2 men and 6 women. Age was ranged from 12 years to 47 years at the lime of presentation (average ; 27.5 years). 2. Four tumors occurred in the right adrenal gland and 5 in the left including a case of bilateral pheochromocytoma. 3. In nonfunctioning tumor (a case of adrenal denoma), the main clinical manifestations were localizing symptoms and signs such as abdominal pain, palpable mass and nonspecific laboratory findings. The others were functioning tumors (2 cases of Cushing`s syndrome due to adrenal adenoma and adrenocortical carcinoma, 2 cases of primary aldosteronism due to drenal demoma, a case of neuroblastoma and 2 cases of pheochromocytoma). There were unique generalized symptoms, signs and laboratory findings due to overproduction of hormones by the tumors 4. Nine adrenalectomies in 8 patients were performed. The weight of resected adrenal mass was 330gm in nonfunctioning adrenal adenoma, 190gm in adrenocortical carcinoma, 5.2gm in Cushing`s syndrome due to derenal adenoma, 2.5gm and 3.2gm in aldosteronism due to adrenal adenoma, 960gm in neurobladstoma, and 85gm, 20gm and 75gm in phepchromocytoma. 5. Results of hormonal assays which were checked 2 days and 2 weeks postoperatively returned to almost normal levels 6. Final characreristic of adrenal tumors could be made mostly by clinical diagnostic procedures, but some of underlying diseases should be differentiated by pathologic confirmation.
Abdominal Pain ; Adenoma ; Adrenal Cortex Neoplasms ; Adrenal Glands ; Adrenalectomy ; Adrenocortical Carcinoma ; Female ; Humans ; Hyperaldosteronism ; Jeollabuk-do ; Male ; Neuroblastoma ; Pheochromocytoma ; Urology

Biopsies of suspected lymphoma cases with history of pre-biopsy corticosteroid therapy present several diagnostic issues, such as the inability to demonstrate the neoplastic hematolymphoid cells, the similarity of post-corticosteroid changes with inflammatory demyelinating lesions, and the possibility of a demyelinating lesion preceding a central nervous system lymphoma. This report presents the case of a 51-year-old immunocompetent male with a solitary callosal mass, with immunomorphologic features suggestive of a demyelinating lesion on initial biopsy, and upon re-biopsy after three months revealed a diffuse large B-cell lymphoma. Awareness of these issues in post-corticosteroid stereotactic biopsy specimens, together with adequate clinical and radiologic data, is important for proper diagnosis and further therapeutic guidance.
Adrenal Cortex Hormones ; Demyelinating Diseases ; Lymphoma

Precocious puberty is difficult to define because of the marked variation in the age at which puberty begins normally, onset of puberty before 8 years of age in girls and 9 years in boys may be considered precocious. The etiology of precocious puberty in boys is usually idiopathic, but can result from adrenal and testicular tumors. The hepatoblastoma that produces hCG is a very rare functioning tumor known to cause precocious puberty in boys. Recently, author experienced one case of virilizing adrenal cortical adenoma in 22 month-old boy, one case of adrenal cortical carcinoma in 28 month-old boy, and one case of virilizing hCG-producing hepatoblastoma in 7 year-old boy and reviewed literatures.
Adolescent ; Adrenocortical Adenoma ; Adrenocortical Carcinoma ; Female ; Hepatoblastoma ; Humans ; Infant ; Male ; Puberty ; Puberty, Precocious ; Testicular Neoplasms

A 44-year-old woman with progressive cervical myelopathy and central cord syndrome was noted to have an extensive cervical intramedullary contrast-enhancing lesion on magnetic resonance imaging (MRI). The lesion resembled a spinal astrocytoma or ependymoma that required surgical intervention. She was subsequently diagnosed to have neuromyelitis optica (NMO), a rare idiopathic inflammatory demyelinating disorder, when the clinical examination revealed left optic atrophy. This was confirmed by a test showing seropositivity for NMO-immunoglobulin (IgG). Disease control was achieved with corticosteroids and immunosuppressive therapy. We report a rare case of a patient with NMO who had MRI features that could have easily led to the condition being misdiagnosed as a spinal cord tumor. The importance of careful history taking, awareness of typical radiological findings and the usefulness of serum NMO-IgG as a diagnostic tool are emphasized.
Adrenal Cortex Hormones ; Adult ; Astrocytoma ; Central Cord Syndrome ; Demyelinating Diseases ; Ependymoma ; Female ; Humans ; Magnetic Resonance Imaging ; Neuromyelitis Optica* ; Optic Atrophy ; Spinal Cord Diseases ; Spinal Cord Neoplasms*

Adrenocortical tumors are very rare in children and the clinical course is not clearly understood. The aim of this study is to review the clinical characteristics and courses of pediatric adrenocortical tumors. The medical records of patients who underwent surgery for primary adrenal tumor at the Department of Surgery, Seoul National University hospital, from Jan. 1986 to Feb. 2006 were reviewed. There were 10 adrenocortical tumor patients; 5 had adrenocortical adenoma and 5 adrenocortical carcinoma. All of the adrenocortical adenomas presented as functioning tumors, i.e., Cushing syndrome or virilization. However, only 2 patients had functioning adrenocortical carcinoma. Median size of adenoma was 5 (3.3-6) cm, and carcinoma 12.5 (6.5-13)cm. Adenomas were smaller than 6 cm and carcinomas were larger than 6.5cm. Surgical resection alone cured all adrenocortical adenoma patients, and they were all alive without recurrence. Three of 5 adrenocortical carcinoma patients died of tumor recurrence despite radical surgery and chemotherapy. There were 2 long-term survivals for adrenocortical carcinoma, one patient survived 10 years without recurrence until he died of newly developed osteosarcoma, and the other patient is alive without recurrence for 20 years. As the prognosis of pediatric adrenocortical carcinoma is poor, peri-operative aggressive chemotherapy is suggested in addition to radical surgery.
Adenoma ; Adrenocortical Adenoma ; Adrenocortical Carcinoma ; Child ; Cushing Syndrome ; Drug Therapy ; Humans ; Medical Records ; Osteosarcoma ; Prognosis ; Recurrence ; Seoul ; Virilism