1.Infective Endocarditis and Chronic Kidney Disease: How to Deal with Complications
Yusra Habib Khan ; Azmi Sarriff ; Amer Hayat Khan ; Azreen Syazril Adnan ; Tauqeer Hussain Mallhi
Malaysian Journal of Medical Sciences 2015;22(4):73-75
Infective endocarditis (IE) is the one of the most important causes of increased mortality and morbidity among haemodialysis patients. The reason for this increasing prevalence of infection among these patients is the use of haemodialysis catheters during dialysis, as these patients are highly susceptible to infections that are easily transmitted via blood access points.
The present case was a geriatric end stage renal disease (ESRD) patient who was readmitted to the hospital two days after her scheduled haemodialysis session with symptoms of nosocomial endocarditis. Her concurrent medical complications were hypertension, non-insulin dependent diabetes mellitus, and ischemic heart disease. Based on her previous medical history and current examination, the patient was suspected to have IE due to catheter related infection.
The goal of therapy is to manage the comorbidities and infection by provision of appropriate treatment based on close monitoring of the patient condition.
2.Re-challenge chemotherapy with gemcitabine plus carboplatin in patients with non-small cell lung cancer.
Khurum KHAN ; Gerard G HANNA ; Lynn CAMPBELL ; Paula SCULLIN ; Adnan HUSSAIN ; Ruth L EAKIN ; Jonathan MCALEESE
Chinese Journal of Cancer 2013;32(10):539-545
Despite recent improvements to current therapies and the emergence of novel agents to manage advanced non-small cell lung cancer (NSCLC), the patients' overall survival remains poor. Re-challenging with first-line chemotherapy upon relapse is common in the management of small cell lung cancer but is not well reported for advanced NSCLC. NSCLC relapse has been attributed to acquired drug resistance, but the repopulation of sensitive clones may also play a role, in which case re-challenge may be appropriate. Here, we report the results of re-challenge with gemcitabine plus carboplatin in 22 patients from a single institution who had previously received gemcitabine plus platinum in the first-line setting and had either partial response or a progression-free interval of longer than 6 months. In this retrospective study, the charts of patients who underwent second-line chemotherapy for NSCLC in our cancer center between January 2005 and April 2010 were reviewed. All the patients who received a combination of gemcitabine and carboplatin for re-challenge were included in the study. These patients were offered second-line treatment on confirmation of clear radiological disease progression. The overall response rate was 15% and disease control rate was 75%. The median survival time was 10.4 months, with 46% of patients alive at 1 year. These results suggest that re-challenge chemotherapy should be considered in selected patients with radiological partial response or a progression-free survival of longer than 6 months to the initial therapy.
Adult
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Aged
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Aged, 80 and over
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Antineoplastic Combined Chemotherapy Protocols
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therapeutic use
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Carboplatin
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administration & dosage
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Carcinoma, Non-Small-Cell Lung
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drug therapy
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pathology
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Deoxycytidine
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administration & dosage
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analogs & derivatives
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Disease Progression
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Disease-Free Survival
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Female
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Follow-Up Studies
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Humans
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Lung Neoplasms
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drug therapy
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pathology
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Male
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Middle Aged
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Neoplasm Staging
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Remission Induction
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Retrospective Studies
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Survival Rate
3.A Longitudinal Survey for Genome-based Identification of SARS-CoV-2 in Sewage Water in Selected Lockdown Areas of Lahore City, Pakistan: A Potential Approach for Future Smart Lockdown Strategy.
Yaqub TAHIR ; Nawaz MUHAMMAD ; Z Shabbir MUHAMMAD ; A Ali MUHAMMAD ; Altaf IMRAN ; Raza SOHAIL ; A B Shabbir MUHAMMAD ; A Ashraf MUHAMMAD ; Z Aziz SYED ; Q Cheema SOHAIL ; B Shah MUHAMMAD ; Rafique SAIRA ; Hassan SOHAIL ; Sardar NAGEEN ; Mehmood ADNAN ; W Aziz MUHAMMAD ; Fazal SEHAR ; Hussain NADIR ; T Khan MUHAMMAD ; M Atique MUHAMMAD ; Asif ALI ; Anwar MUHAMMAD ; A Awan NABEEL ; U Younis MUHAMMAD ; A Bhattee MUHAMMAD ; Tahir ZARFISHAN ; Mukhtar NADIA ; Sarwar HUDA ; S Rana MAAZ ; Farooq OMAIR
Biomedical and Environmental Sciences 2021;34(9):729-733