1.A Clinical Study of Oral Ketoconazole Therapy in Superficial Fungal Diseases: Multicenter Trials.
Do Sik SONG ; Byung In RO ; Chin Yo CHANG ; Hyung Ok KIM ; Choong Rim HAW ; Jae Bok JUN ; Sook Ja SON ; Jai Il YOUN ; Ki Bum MYUNG ; Jae Hong KIM
Korean Journal of Dermatology 1984;22(3):263-272
Ketoconazole is one of the broad-spectrum oral antimycotic agents recently developed from imidazole derivatives. Authors performed multicenter trials to evaluate the therapeutic effect of ketoconazole in superficial fungal diseases. One hundred and eighty-four patients with superficial fungaI diseases were included in this study during 7 months from April to October, 1983 Patiets were treated with oral administration of 200 mg of ketoconazole(Nizoral) once a day for 4 weeks.-countinue-
Administration, Oral
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Humans
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Ketoconazole*
2.The Bactericidal Activity of Serum of Leprosy Patients.
Korean Journal of Preventive Medicine 1975;8(1):7-14
The bactericidal activity of 96 sera, to Staphylococci and E.coli, of leprosy patients classified as sever, mild, and negative grade by bacterial index was investigated. The results obtained were as follows; The killing activity to E. coli, in general, was stronger than that to Staphylococci. The bactericidal activity of serum was variable by serum itself, and these variations were more remarkablh in Ei coli than in Staphylococci. In case to E. coli, the higher bactericidal activity was observed in the serum of mild and negative grade patients rather than sever, while no relationship was found between activity and disease grade in Staphylococci. The per oral administration of DDS and Lampren did not give any influence to the bactericidal activity of serum.
Administration, Oral
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Homicide
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Humans
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Leprosy*
3.Acupuncture treatment of vocal nodule and evaluation of the therapeutic effect by computerized acoustics assay.
Chinese Acupuncture & Moxibustion 2005;25(6):404-406
OBJECTIVETo evaluate the therapeutic effect of acupuncture at point Kaiyin No. 1 on vocal nodule.
METHODSEighty cases of vocal nodule were randomly divided into an acupuncture group of 40 cases, a Chinese herb group of 20 cases and a western medicine group of 20 cases. The acupuncture group were treated with acupuncture at main point Kaiyin No. 1, the Chinese herb group with oral administration of Jinsang Sanjie Pill and the Western medicine group with spray inhalation of antibiotics and hormones. Their therapeutic effects and parameters of acoustics before and after treatment were observed.
RESULTSThe total effective rate was 92.5% in the acupuncture group, significantly better than 85.0% in the Chinese herb group and 85.0% in the Western medicine group (P < 0. 01); the acupuncture group in improvement of parameters of acoustics was significantly superior to other two groups (both P < 0.01).
CONCLUSIONAcupuncture at point Kaiyin No. 1 has significant therapeutic effect on vocal nodule with no adverse effect.
Acupuncture Therapy ; Administration, Oral ; Humans
4.Pharmaceutics research advances in oral administration of puerarin.
Wen-Ting WU ; Bin ZOU ; Wen-Dong LI ; Wei-Feng ZHU
China Journal of Chinese Materia Medica 2019;44(19):4134-4141
Puerarin is a naturally occurring isoflavone C-glycoside,isolated from the root of Pueraria lobata,which has attracted extensive attention in the medical circles because of its various pharmacological effects,such as vasodilation,cardioprotection,neuroprotection,antioxidant,anticancer,anti-inflammation,alleviating pain,promoting bone formation,inhibiting alcohol intake,and attenuating insulin resistance. However,its low oral bioavailability has limited its clinical application. This review gives a comprehensive summary of the researches on physicochemical properties,pharmacokinetics( absorption,distribution,metabolism and excretion,pharmacokinetic parameters) in oral administration,and pharmaceutics research strategies of puerarin in recent years,and the in vivo behavior difference between multicomponent and single component environment was also summarized. The reasons( low water solubility,poor membrane permeability,short half-life,inhibition of P-gp efflux and first-pass metabolic effects of intestinal enzymes,etc.) for low bioavailability were concluded and the idea that multicomponent enviroment would affect the bioavailability was clarified. The aim of this review is to provide literature basis for the development of new dosage forms and new technologies for multivariate compound drug delivery system to improve the bioavailability of oral puerarin,and to propose ways to improve the bioavailability of BCS Ⅳ drugs derived from traditional Chinese medicine by fully enlarging the synergistic effect of multi-components or reasonably using the inhibitory effect between components.
Administration, Oral
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Biopharmaceutics
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Isoflavones
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Pueraria
5.Oral chemotherapeutic agents in current use.
Namsu LEE ; Kyoung Ha KIM ; Sang Cheol LEE
Journal of the Korean Medical Association 2011;54(11):1191-1198
Currently, 10% of cancer chemotherapy is provided to patients by oral formulation; however, by 2013 this percentage is predicted to increase to 25%. Chemotherapy is traditionally given by injection. Oral chemotherapy has been developed as a more convenient method for treating patients. Oral chemotherapy offers many advantages including the elimination of pain often caused by injections, the lack of fees for administering intravenous drugs, more time at home for patients, and a patient's increased sense of autonomy. The role of oral chemotherapy has been expanding because of the potential advantages in convenience and better quality of life for patients, and in the cost-effectiveness of treatment as compared to intravenous chemotherapy. A number of novel oral targeted and cytotoxic chemotherapeutic agents are entering the market or are in development. Many of the agents display significant clinical activity against various cancers. The growing availability of effective oral chemotherapy treatments, especially the new class of 'targeted biologic therapies', is one of the wonderful recent advances in cancer care. This manuscript describes the progress of clinical development and efficacy of these newly developed chemotherapeutic agents.
Administration, Oral
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Fees and Charges
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Humans
;
Quality of Life
6.The study of blood carbon disulfide in rats after oral administration of carbon disulfide.
Muyung Hwa CHO ; Jae Hoon ROH ; Kyung Jong LEE ; Chi Nyun KIM ; Yong Bong CHO ; Young Hahn MOON
Korean Journal of Occupational and Environmental Medicine 1993;5(2):216-222
No abstract available.
Administration, Oral*
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Animals
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Carbon Disulfide*
;
Carbon*
;
Rats*
7.Use of methylcellulose in Small-Bowel Follow-Through Examination: Comparison with Enteroclysis and Conventional Series in Normal Subjects.
Kwang Bo PARK ; Hyun Kwon HA ; Se Ho SON ; Jae Cheul HWANG ; Eun Kyung JI ; Nam Hyeon KIM ; Pyo Nyun KIM ; Moon Kyu LEE ; Yong Ho AUH
Journal of the Korean Radiological Society 1996;35(3):351-356
PURPOSE: To evaluate the efficacy of a modified small bowel follow-through (SBFT) and to optimize this technique. MATERIALS AND METHODS: Ninety-nine subjects without small bowel pathology underwent modified SBFT using oral administration of methylcellulose after taking 100ml of 120% or 100, 150, or 200ml of 70% barium. Thirty-three and 39 normal subjects undergoing enteroclysis or conventional SBFT, respectively, were also evaluated for comparison of image qualities and transit time. RESULTS: Enteroclysis was the most successful ofthree types of small bowel examination for obtaining the best quality of bowel transradiency and distension. Modified SBFT was, however much superior to the conventional series for obtaining good bowel transradiency and rapid transity time (mean, 37-49 minutes). The use of 150ml of 70% barium was better than the other three modified techniques in achieving good bowel transradiency, rapid transit time, and less flocculation. CONCLUSION: Our modified SBFT is a simple and safe method for easily improving bowel transradiency and transit time.
Administration, Oral
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Barium
;
Flocculation
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Methylcellulose*
;
Pathology
8.Cold Urticaria: Ice Cube Test and Treatment.
Kye Eun CHO ; Chung Koo CHO ; Yung Lae KIM ; Tae Ha WOO
Korean Journal of Dermatology 1970;8(2):47-49
In an attempt to treat the cold urticaria, a new bradykinin inhibitor, homoclomin was administered orally and effective result were obtained. The urticaria was confirmed by the employing the ice cube test on the patient and the positive reaction was appeared generally 10 sec. to 15 min. after application of ice cube on the forearm. After oral administration for 3 days (40mg/day) clinical symptoms were relieved temporarily and weakly positive or negative reaction observed in repeated ice cube test.
Administration, Oral
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Bradykinin
;
Forearm
;
Humans
;
Ice*
;
Urticaria*
9.Induction of preneoplastic lesion in the large intestine of rats by oral administration of 2-amino-1-methyl-6-phenylimidazo4,5-bpyridine.
Yong Suk KIM ; Kwang Soo LEE ; Kye Young JUN
Journal of the Korean Society of Coloproctology 1993;9(2):125-130
No abstract available.
Administration, Oral*
;
Animals
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Intestine, Large*
;
Rats*
10.Induction of preneoplastic lesion in the large intestine of rats by oral administration of 2-amino-1-methyl-6-phenylimidazo4,5-bpyridine.
Yong Suk KIM ; Kwang Soo LEE ; Kye Young JUN
Journal of the Korean Society of Coloproctology 1993;9(2):125-130
No abstract available.
Administration, Oral*
;
Animals
;
Intestine, Large*
;
Rats*