1.The Role of Polymorphism of Adiponectin Gene in the Atherosclerosis.
Journal of Korean Society of Endocrinology 2005;20(1):8-11
No abstract available.
Adiponectin*
;
Atherosclerosis*
2.Relationship between plasma adiponectin level and corrected QT interval in smoker and non-smoker adult male subjects
Yin Thu Theint ; Ei Ei Khin ; Ohnmar Myint Thein ; Mya Thanda Sein
Journal of the ASEAN Federation of Endocrine Societies 2020;35(2):190-195
Objective. This study determined the relationship between plasma adiponectin level and corrected QT interval (QTc) in smokers and non-smokers.
Methodology.This cross-sectional analytical study was undertaken in 30 smokers and 30 non-smokers. Plasma adiponectin level was determined by enzyme-linked immunosorbent assay (ELISA). The QT interval was measured by routine 12-lead ECG with Lead II rhythm and QTc was calculated.
Results. Mean plasma adiponectin level was significantly lower in smokers (27.89±15 μg/ml) than that of non-smokers (52.13±21.57μg/ml) (p<0.001). Mean QTc interval was significantly longer in smokers than that of non-smokers (415.37±29.9 versus 395.63±26.13 ms, p<0.01). Higher risk of low adiponectin level (odds ratio [OR],8.1; 95% confidence interval [CI],1.61-40.77) and QTc interval prolongation (OR,6; 95%CI,1.17-30.73) were observed in smokers. There was weak significant negative correlation between plasma adiponectin level and QTc interval in the study population (n=60, r=-0.407, p=0.001). Moreover, low plasma adiponectin level was significantly associated with prolonged QTc interval in the study population (n=60, Fisher's exact p value<0.05). Risk of QTc interval prolongation was 4.3 times higher in subjects with low plasma adiponectin level (OR,4.27; 95% CI,1.05-17.46).
Conclusion. Smokers have greater risk for low plasma adiponectin level and prolonged QTc interval. There is a relationship between plasma adiponectin level and QTc interval.
Smokers
;
adiponectin
3.T45G Adiponectin Gene Polymorphism and its association with Hyperglycemia in adult Filipinos seen at the Philippine General Hospital - A pilot study
Elizabeth Paz-Pacheco ; Eva Maria Cutiongco-dela Paz ; Angelique Bea C. Uy
Acta Medica Philippina 2020;54(4):400-406
Introduction:
Adiponectin is an adipocytokine known to have anti-inflammatory and anti-atherogenic effects. It appears to impact insulin resistance and the subsequent development of type 2 diabetes mellitus (T2D). The gene encoding adiponectin ADIPOQ, has single nucleotide polymorphisms (SNPs) that can be useful biomarkers to predict development of T2D; with the T/G polymorphism of SNP +45 in exon 2 being the most common.
Objective:
This study was conducted to evaluate the association of T45G adiponectin gene polymorphism with hyperglycemia among adult Filipinos seen at the outpatient department of the Philippine General Hospital.
Methods:
This is a matched case-control study, with duration of 12 months. DNA was extracted using the QIAGEN MIDI Blood Extraction Kit. The genomic DNA obtained was then subjected to real time PCR for SNP detection.
Results:
One hundred (100) adults were enrolled; forty-three (43) had normoglycemia, while fifty seven (57) had hyperglycemia, after a 75-g oral glucose tolerance test. Hyperglycemic subjects were older (44±15.6 years vs. 52±8.3 years, p-value 0.002), and had lower HDL levels (58.5±16.0 mg/dLvs. 47.8+11.8 mg/dL, p-value 0.000). Among thirty-nine (39) participants found to have the T45G adiponectin gene polymorphism, 22 or 56.4% were hyperglycemic while 17 or 43.6% were normoglycemic.
Conclusion
There was no significant association observed between the T45G SNP and presence of hyperglycemia.
Adiponectin
;
Hyperglycemia
4.The Plasma Adiponectin Levels in Patients with Newly Diagnosed Type 2 Diabetes.
Ihn Suk LEE ; Bon Jeong KU ; Young Kun KIM
Korean Diabetes Journal 2008;32(2):173-174
No abstract available.
Adiponectin
;
Humans
;
Plasma
5.Relation between Adiponectin and Metabolic Risk Factors.
Journal of Korean Society of Endocrinology 2005;20(5):441-443
No abstract available.
Adiponectin*
;
Risk Factors*
6.The Plasma Adiponectin Levels in Patients with Newly Diagnosed Type 2 Diabetes.
Korean Diabetes Journal 2008;32(1):83-83
No abstract available.
Adiponectin
;
Humans
;
Plasma
7.Non-alcoholic Fatty Liver Disease and Adiponectin.
Korean Diabetes Journal 2008;32(2):98-101
No abstract available.
Adiponectin
;
Fatty Liver
8.Effect of adiponectin on nonalcoholic fatty liver disease.
Wei SUN ; Zheng JIANG ; Pi-Long WANG
Chinese Journal of Hepatology 2006;14(12):952-954
9.Insight into Adiponectin Role in Metabolic and Cardiovascular Disease as a Potential Therapeutic Strategy
Hyekyung YANG ; Cheol Young PARK
Korean Journal of Obesity 2015;24(3):137-139
No abstract available.
Adiponectin
;
Cardiovascular Diseases
10.Adiponectin Promotes Caspase-14 Expression in Normal Human Epidermal Keratinocytes
Sun Young CHOI ; Min Jeong KIM ; Ji Yeon HONG ; Kui Young PARK ; Seong Jun SEO
Annals of Dermatology 2019;31(3):352-355
No abstract available.
Adiponectin
;
Caspase 14
;
Humans
;
Keratinocytes