1.Intranuclear Cytoplasmic Pseudoinclusions in Pituitary Adenomas.
Seok Woo YANG ; Kyung Moo YANG ; Hae Youn KANG ; Tai Seung KIM
Yonsei Medical Journal 2003;44(5):816-820
Intranuclear pseudoinclusions are well known in papillary carcinomas of the thyroid gland, hepatocellular carcinomas, meningiomas, paragangliomas, pheochromocytomas, and melanomas. Only two papers on the intranuclear inclusions of adenohypophyseal cells in humans have been reported. This study found that intranuclear cytoplasmic pseudoinclusions occur frequently in pituitary adenoma cases (70.3%, 97 of 138 pituitary adenomas) and are uncommon in normal pituitary tissue (11.1%, 1 of 9 normal pituitary tissues). In addition, the frequency of intranuclear cytoplasmic pseudoinclusions between the functional and non-functional pituitary adenomas was found to be similar. Electron microscopy and immunostaining was used to reveal the entity of the intranuclear inclusion. These intranuclear inclusions are due to cytoplasmic invagination because 1) the inclusions are continuous with the cytoplasm, 2) all cytoplasmic organelles, such as the endoplasmic reticulum, the Golgi apparatus, and the secretory granules are found in the inclusions, 3) immunoreactivity of the intranuclear inclusion is the same as that of the cytoplasm. In conclusion, intranuclear cytoplasmic pseudoinclusions in pituitary adenomas occur frequently (70.3%) and are formed by cytoplasmic invagination. This study suggests that pituitary intranuclear inclusions caused by cytoplasmic invagination be called "intranuclear cytoplasmic pseudoinclusions".
Adenoma/pathology/*ultrastructure
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Adolescent
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Adult
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Aged
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Female
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Human
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Intranuclear Inclusion Bodies/*ultrastructure
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Male
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Microscopy, Electron
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Middle Aged
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Pituitary Neoplasms/pathology/*ultrastructure
2.Recently identified renal cell carcinoma.
Ming ZHAO ; Xiao-dong TENG ; Ke SUN ; Liang CHENG
Chinese Journal of Pathology 2013;42(7):478-482
Adenocarcinoma, Follicular
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metabolism
;
pathology
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Adenoma, Chromophobe
;
metabolism
;
pathology
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Adenoma, Oxyphilic
;
metabolism
;
pathology
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Angiomyoma
;
metabolism
;
pathology
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Biomarkers, Tumor
;
metabolism
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Carcinoma, Papillary
;
metabolism
;
pathology
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Carcinoma, Renal Cell
;
classification
;
metabolism
;
pathology
;
ultrastructure
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Diagnosis, Differential
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Humans
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Kidney Neoplasms
;
classification
;
metabolism
;
pathology
;
ultrastructure
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Thyroid Neoplasms
;
metabolism
;
pathology
3.Wolffian adnexal tumor: report of a case.
Ren-qiao LIU ; Zhen-huan ZHANG ; Min-hong PAN ; Zhi-hong ZHANG ; Qin-he FAN
Chinese Journal of Pathology 2013;42(7):476-477
Adenoma
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metabolism
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pathology
;
surgery
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ultrastructure
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Adnexa Uteri
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pathology
;
surgery
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Adnexal Diseases
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metabolism
;
pathology
;
surgery
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Carcinoma, Endometrioid
;
metabolism
;
pathology
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Diagnosis, Differential
;
Female
;
Granulosa Cell Tumor
;
metabolism
;
pathology
;
Humans
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Hysterectomy
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Keratins
;
metabolism
;
Leiomyomatosis
;
pathology
;
surgery
;
Microscopy, Electron
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Middle Aged
;
Neoplasms, Multiple Primary
;
metabolism
;
pathology
;
surgery
;
ultrastructure
;
Sertoli-Leydig Cell Tumor
;
metabolism
;
pathology
;
Uterine Neoplasms
;
pathology
;
surgery
;
Vimentin
;
metabolism
;
WT1 Proteins
;
metabolism