1.Clinicopathologic Evaluation of Endoscopic Mucosal Resection of Early Gastric Carcinomas and Gastric Adenomas.
In Sik CHUNG ; Kyu Won CHUNG ; Hee Sik SUN ; Doo Ho PARK ; Sok Won HAN ; Kyu Yong CHOI ; Soo Heon PARK ; Myung Gyu CHOI ; Hiun Suk CHAE ; Choon Sang BHANG
Korean Journal of Gastrointestinal Endoscopy 1996;16(1):15-24
The endoscopic mucosal resection is a useful method of both accurate diagnosis and treatment of gastric mucosal lesion and has been accepted as a standard procedure of early gastric cancer. Over the 3 year period from 1992 to 1994, 57 adenomas and 10 early gastric carcinomas were resected endoscopically at the St. Mary's hospital of Catholic University Medical College. The purpose of this study was to clarify the technical limitations of endoscopic mucosal resection with respect to size, location, methods. (continue...)
Adenoma*
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Diagnosis
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Stomach Neoplasms
2.Cholangiome-identifying features in the film of cholangiography
Journal of Practical Medicine 2002;430(9):50-52
40 patients diagnosed as cholangiome of which 9 patients diagnosed by biliary cell, 13 patients diagnosed by CT scanner, and 18 patients diagnosed by operation. The biliary obstruction in the general hepatic tube occurred in 95% of patients in which the lesion involved in the 2 branches of liver was 75%. The image of cholangiome in the film of cholangiography found that biliary fair stenosid (62,5%).
Adenoma, Bile Duct
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diagnosis
3.Tubular Apocrine Adenoma: A case report.
Seong Beom LEE ; Jeana KIM ; Seok Jin KANG ; Sun Moo KIM
Korean Journal of Pathology 1995;29(6):797-799
Tubular apocrine adenoma is a rare benign tumor occuring most often on the scalp. We examined a case of a 69-year-old female who had a well demarcated solid nodule on the scalp. Pathol Microscopically, the tumor was composed of lobules of tubular structures. The tumor lobules were surrounded by a stroma of dense fibrous connective tissue. The tubular structures were usually formed of two rows of epithelial cells. In some areas, the widely dilated tubular structures showed papillary projections into the cavities. Some epithelial cells showed liculoma on decapitation secretion into the cystic structure. Problems of differential diagnosis with other adnexal tumors are briefly discussed.
Female
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Humans
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Diagnosis, Differential
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Adenoma
4.Correlation of Expression of galectin-3, skp2, p27 and cyclin D1 in Benign and Malignant Thyroid Lesions.
Soon Auck HONG ; Min Eui HONG ; Gui Young KWON ; Mi Kyung KIM
Korean Journal of Pathology 2008;42(3):134-139
BACKGROUND: The overexpression of cyclin D1 and galectin-3 and the loss of p27 in thyroid cancers have recently been reported by many studies. The S-phase kinase associated protein 2 (skp2) plays an important role in the degradation of p27. We compared the correlation of the expressions of galectin-3, p27, cyclin D1 and skp2 in thyroid lesions. METHODS: Sixty five cases were included in this study and immunohistochemical staining for galectin-3, skp2, p27 and cyclin D1 was performed. RESULTS: The expression of galectin-3 increased in the order of nodular hyperplasia, follicular adenoma, follicular carcinoma and papillary carcinoma (p<0.01). The expression rate of skp2 was 0% for nodular hyperplasia, 16.7% for follicular adenoma, 33.3% for follicular carcinoma and 16.7% for papillary carcinoma. The loss of the expression of p27 was more frequently detected in papillary carcinoma as compared with nodular hyperplasia (p<0.01). The increased expression of cyclin D1 was noted in follicular adenoma and carcinoma as compared with nodular hyperplasia (p=0.043). The expression of galectin-3 was related with the loss of a p27 expression (p<0.01), and the expression of skp2 was related with the expression of the cyclin D1 (p=0.022). CONCLUSIONS: Galectin-3 appears to be the most useful marker for making the diagnosis of thyroid lesions. The loss of a p27 expression can help differentiate nodular hyperplasia and papillary carcinoma, and the determining the expression of cyclin D1 may be helpful for the differential diagnosis of nodular hyperplasia and follicular neoplasm.
Diagnosis, Differential
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Adenoma
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Thyroid Neoplasms
5.Tubulovillous and Villous Adenomas of the Colon and Rectum - Endoscopic Characteristics and Management.
Hyun Shig KIM ; Kuhn Uk KIM ; Weon Kap PARK ; Kwang Real LEE ; Jung Jun YOO ; Seok Won LIM ; Jong Kyun LEE
Korean Journal of Gastrointestinal Endoscopy 1998;18(4):506-519
BACKGROUND/AIMS: A villous tumor, histologically villous or tubulovillous adenoma, is a clinical challenge because of its higher potential for malignancy and higher recurrence rate. However, information and experience with these tumors in the Korean people is still lacking. For that reason, we designed this study to review and analyze the colonoscopic features, the potential for malignancy, and the treatiment with respect to the confirmation of guidelines for the accurate diagnosis and reasonable management of such tumors in the Korean population. MATERIALS AND METHODS: We performed 753 polypectomies, including 4 transanal excisions and several bowel resections, from January 1996 to May 1997 at Song-Do Colorectal Hospital in Seoul, Among them, 447 cases (59.4%) were adenomas, comprising 405 (53.8%) tubular adenomas, 31 (4.1%) tubulovillous adenomas, and 11 (1.5%) villous adenomas. We analyzed the 42 (5.6%) tubulovillous and villous adenomas.
Adenoma
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Adenoma, Villous*
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Colon*
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Diagnosis
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Rectum*
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Recurrence
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Seoul
6.Malignant Change of Pleomorphic Adenoma.
Choong Ki JUNG ; Sung Mi KIM ; Ja Young LEE ; Sung Kun CHUNG
Journal of the Korean Ophthalmological Society 1997;38(12):2251-
A 54-year-old man had complained of proptosis on his right eye. Computed tomography showedlarge mass on superotemporal portion of right orbit. Surgical removal was done through the lateral orbitotomy. The histopathological diagnosis demonstrated pleomophic adenoma. Seven Years later, the patient revisited complaing of proptosis on his right eye. Magnetic resonance image demonstrated ill defined mass on the same iste. We excised mass including psuedocapsule and surrounding tissue.
Adenoma
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Adenoma, Pleomorphic*
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Diagnosis
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Exophthalmos
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Humans
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Middle Aged
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Orbit
7.Clinicopathological observation of renal adenomas.
Lina LIU ; Changhuai ZHANG ; Shoufang HUANG
Chinese Journal of Pathology 2002;31(3):204-207
OBJECTIVETo investigate the morphologic features and diagnostic criteria of various types pf renal adenomas of the kidney.
METHODSIn addition to light microscopy, electron microscopy, histochemical and immunohistochemical assays were applied. All 19 cases of adenomas were followed up.
RESULTSThree (3) cases of papillary adenoma were featured as papillary or tubulopapillary growth in patterns consisting of tumor cells with basophilic or acidophilic cytoplasm and were positive for both epithelial membrane antigen (EMA) and cytokeratin (CK7). Thirteen (13) cases of oncocytoma were characterized by the diversity of the structures including to be nest, tubular and papillary in pattern; a mixture of cell types including the classic oncocytes, oncoblasts and clear cells which were negative for vimentin and CK7 but positive for EMA. Enormous large mitochondria were obtained in 4 cases of oncocytoma by electronic microscopy. Three (3) cases of metanephric adenoma consisted of closely packed, round tubules lined by small bland cells with solid, glomeruloid constructure. Branching, elongated tubules and polypoid fronds were also detected. Tumor cells were negative for EMA, negative or only focally positive for CK7. Eighteen (18) patients were alive except one oncocytoma patient died 5 years after the diagnosis convinced. All the cases reported in this article had been followed up of 3 - 5 years.
CONCLUSIONSThere are 3 kinds of renal adenomas, namely, the papillary adenoma, oncocytoma, and metanephric adenoma and each kind has its own clincopathological features. The latter two can be recognized by their distinctive morphology, and the former can only be diagnosed according to the size of the tumor as the reference. Histochemical and immohistochemical assays are helpful in differential diagnosis.
Adenoma ; Adenoma, Oxyphilic ; Diagnosis, Differential ; Humans ; Kidney ; Kidney Neoplasms
8.Peutz-Jeghers Syndrome with Extensive Epithelial Misplacements and Adenomatous and Carcinomatous Transformation: A case report.
Jeong Ja KWAK ; So Young JIN ; Dong Wha LEE
Korean Journal of Pathology 1993;27(6):630-637
Peutz-Jeghers syndrome is an autosomal dominant disease characterized by gastrointestinal ployposis and mucocutaneous melanin pigmentation involving the lip, oral mucosa, digits, palms and soles. The polyps are almost hamartomatous. The relationship of gastrointestinal carcinoma and the Peutz-Jeghers syndrome has been discussed for many years. The question is unsettled whether gastrointestinal carcinoma arise in hamartomatous polyps itself. Recently, there are a few reports that adenomatous and carcinomatous changes were superimposed upon the background of the hamartoma. Occasionally epithelial misplacement of the epithelium is found in the small intestinal polyps. Since the epithelial misplacement may involve submucosa, muscularis propria and serosa, a difficulty of histopathologic differential diagnosis between the epithelial misplacement and invasive adenocarcinoma cause overdiagnosis of cancer in the gastrointestinal polyps of Peutz-Jeghers syndrome. We present a case of Peutz-Jeghers syndrome of 39-year-old woman with multiple gastrointestinal polyps, two of which showed extensive epithelial misplacement even into the pancreas and another one at the colon showed carcinomatous change at the tip portion. Areas of hamartoma, adenoma and in situ carcinoma were noted in this colonic hamartomatous polyp. This case support that adenoma and carcinomatous changes may evolve directly within a hamartomaous polyp itself.
Female
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Humans
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Diagnosis, Differential
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Adenocarcinoma
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Adenoma
9.Clinical value of captopril test in noninvasive diagnosis of aldosterone-producing adenoma.
Bo DONG ; Xiao Wei MA ; Xiao Hui GUO ; Ying GAO ; Jun Qing ZHANG
Journal of Peking University(Health Sciences) 2021;53(6):1128-1132
OBJECTIVE:
To analyze the clinical characteristics of aldosterone-producing adenoma (APA) subtypes in primary aldosteronism (PA) and the application value of captopril challenge test (CCT) in adenomas. And to find out the clinically specific non-invasive index for identifying APA subtypes from PA.
METHODS:
The clinical data of hospitalized patients with hypertension were retrospectively collected. All the patients were conducted with the CCT and 90 patients with PA were confirmed. Among them, 34 patients were confirmed to have APA by surgery. The clinical indicators of the two groups of patients including plasma aldosterone concentration (PAC), aldosterone inhibition rate (%), and aldosterone to renin ratio (ARR) before and after the CCT were compared, the receiver operating characteristic (ROC) curves for the relevant indicators before and after the CCT drawn, and the areas under the curve (AUC) compared. The ROC curves were used to analyze the efficiency of the different CCT diagnostic criteria for diagnosing APA.
RESULTS:
Compared with the PA group, the duration of hypertension was shorter, the incidence of hypokalemia was higher, and the average serum potassium level was lower when APA was diagnosed. There were no significant differences in blood pressure level, gender, serum sodium and body mass index between the two groups. Compared with PA population, APA group had higher PAC and ARR whether before or after the CCT, but lower plasma renin concentration (PRC). In APA patients, the mean degree of PAC declined after CCT was approximately 5.7%, but 5% with that of PA. As for diagnosing, ARR before or after CCT had diagnostic value for APA, in which the ARR cut-off point was 7.12, which yielded a sensitivity and specificity of 35.85% and 77.78%. The cut-off point of ARR after CCT was 4.23, with a sensitivity of 71.43% and specificity of 62.22%. For the diagnosis, the ARR before and after CCT were of no significant difference. However, the diagnostic specificity of ARR>7.12 combined with hypokalemia was up to 80%.
CONCLUSION
ARR before or after CCT have clinical value for the diagnosis of APA from PA, when combined with hypokalemia yielded high specificity.
Adenoma/diagnosis*
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Aldosterone
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Captopril
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Humans
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Retrospective Studies
10.A Case of Ceruminous Adenoma Arising from the External Auditory Canal.
Seong Chul YEO ; Ho Joong LEE ; Jin Yong KIM ; Dae Whan KIM ; Jin Hyun SEO ; Seong Ki AHN
Kosin Medical Journal 2018;33(2):228-234
Ceruminous adenoma is a benign neoplasm of the ceruminous gland, and its development in human external auditory canal is very rare. Due to the limited number of cases, controversy still exists about nomenclature, classification, diagnosis and its treatment. Recently we experienced a 55 years old woman who was diagnosed with ceruminous adenoma of the external auditory canal, and who was treated with wide excision. So we report this uncommon case in combination with a review of the literature.
Adenoma*
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Classification
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Diagnosis
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Ear Canal*
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Female
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Humans