2.Pituitary adenoma with initial symptom of cerebrospinal fluid rhinorrhea: a case report.
Journal of Clinical Otorhinolaryngology Head and Neck Surgery 2014;28(17):1358-1359
Pituitary adenoma with cerebrospinal fluid rhinorrhea is rare clinically. In this paper, through the analysis of a pituitary adenoma patient with initial symptom of cerebrospinal fluid rhinorrhea, we look forward to provide evidence for clinical diagnosis, so that we can avoid misdiagnosis.
Adenoma
;
complications
;
diagnosis
;
Cerebrospinal Fluid Rhinorrhea
;
etiology
;
Humans
;
Pituitary Neoplasms
;
complications
;
diagnosis
3.A case report of ectopic parathyroid adenoma on piriform fossa.
Chen YANG ; Shi-li WANG ; Chang-ping CAI
Chinese Journal of Otorhinolaryngology Head and Neck Surgery 2010;45(8):694-695
Adenoma
;
diagnosis
;
etiology
;
Adult
;
Esophageal Neoplasms
;
complications
;
diagnosis
;
Humans
;
Male
;
Parathyroid Neoplasms
;
diagnosis
;
etiology
4.Comparison of coagulation function between adrenocorticotropic hormone independent Cushing syndrome and nonfunctional adrenal adenoma and its influence factors.
Wei WANG ; Jia Ning WANG ; Wei YU ; Sai Nan ZHU ; Ying GAO ; Jun Qing ZHANG
Journal of Peking University(Health Sciences) 2023;55(6):1062-1067
OBJECTIVE:
To investigate the coagulation function indicators and identify influence factors of hypercoagulability in patients with adrenocorticotropic hormone (ACTH) independent Cushing syndrome (CS).
METHODS:
In our retrospective study, the electronic medical records system of Peking University First Hospital was searched for the patients diagnosed with ACTH independent CS on discharge from January 2014 to June 2019. Nonfunctional adrenal adenoma patients were chosen as control group and matched 1 ∶1 by body mass index (BMI), gender, and discharge date. Clinical features and coagulation function indicators were compared between the two groups.
RESULTS:
In the study, 171 patients were included in each group. Compared with control group, activated partial thromboplastin time (APTT), and prothrombin time (PT) in ACTH independent CS group were significantly lower [(29.22±3.39) s vs. (31.86±3.63) s, P < 0.001; (29.22±3.39) s vs. (31.86±3.63) s, P < 0.001], and both D-dimer and fibrin degradation products (FDP) levels were significantly higher (P < 0.05). Percentage of APTT levels under the lower limit of reference range in the CS patients was significantly higher than that in nonfunctional group (21.6% vs. 3.5%, P < 0.001). Percentage of D-dimer levels over the upper limit of reference range in the CS patients was significantly higher than that in nonfunctional group (13.5% vs. 6.6%, P=0.041). There were three patients with deep venous thrombosis and one patient with pulmonary embolism in CS group, however none was in control group. The area under curve (AUC) of serum cortisol rhythm (8:00, 16:00 and 24:00) levels was negatively associated with the levels of PT (r=-0.315, P < 0.001) and APTT (r=-0.410, P < 0.001), and positively associated with FDP (r=0.303, P < 0.001) and D-dimer levels (r=0.258, P < 0.001). There were no differences in coagulation function indicators among different histopathologic subgroups (adrenocortical adenoma, adrenocortical hyperplasia, oncocytic adenoma, adrenocortical carcinoma). With Logistic regression analysis, the AUC of cortisol and glycosylated hemoglobin A1c (HbA1c) levels were independent risk factors for hypercoagulability in the ACTH independent CS patients (P < 0.05).
CONCLUSION
ACTH independent CS patients were more likely in hypercoagulable state compared with nonfunctional adrenal adenoma, especially in ACTH independent CS patients with higher levels of cortisol AUC and HbA1c. These patients should be paid attention to for the hypercoagulability and thrombosis risk.
Humans
;
Cushing Syndrome/complications*
;
Adrenocortical Adenoma/complications*
;
Adrenocorticotropic Hormone
;
Hydrocortisone
;
Retrospective Studies
;
Glycated Hemoglobin
;
Adrenal Cortex Neoplasms/diagnosis*
;
Adenoma/diagnosis*
;
Thrombophilia/complications*
5.A Case of Gastritis Cystica Profunda Associated with High Grade Tubular Adenoma.
Young Lim SONG ; Joon Yong PARK ; Yong Bum KIM ; Ki Joo KANG ; Hee Seon KIM ; Dae Ro CHOI ; Ho Sung YOON ; Ja Young LEE ; Kyung Ho KIM ; Jin Heon LEE ; Hak Yang KIM ; Jae Young YOO
The Korean Journal of Gastroenterology 2004;43(1):52-55
Gastritis cystica profunda is usually characterized by hyperplastic and cystic dilatation of pseudopyloric gland with submucosal invasion. These lesions possess malignant histologic features as metaplastic and even dysplastic alteration can be observed, however they usually exhibit benign behavior. Macroscopically, gastritis cystica profunda may present as a submucosal tumor or as a polyp. In rare case, however, it can be found as a giant mucosal fold. The proposed pathogenesis of lesion relates to ischemia, chronic inflammation, and the presence of foreign body. Herein, we report a case of gastritis cystica profunda associated with high grade tubular adenoma in a patient without antecedent surgery.
Adenoma/*complications/pathology
;
English Abstract
;
Gastritis/*complications/diagnosis/pathology
;
Humans
;
Male
;
Middle Aged
;
Stomach Neoplasms/*complications/pathology
6.Endoscopic Endonasal Transsphenoidal Pituitary Tumor Surgery: An Early Experience.
Jong Hyun KIM ; Hun Jong DHONG ; Byung Moon CHO ; Dong Ik SHIN ; Do Hyun NAM ; Jung Il LEE ; Jong Soo KIM ; Seung Chyul HONG ; Hyung Jin SHIN ; Kwan PARK ; Whan EOH
Journal of Korean Neurosurgical Society 1999;28(6):769-774
Endoscopic surgery opened new fields in pituitary tumor surgery, not only by direct endonasal access, but also by affording a panoramic view inside the sphenoidal sinus and the sellar turcica. It provides an extremely sharp image with high resolution. We describe our initial experience in using the endonasal endoscopy for the pituitary tumor surgery. Seven operations were performed by the endonasal endoscopy. The endoclinologic diagnosis were prolactinoma in four cases and GH secreating adenoma in three. Four cases were macroadenoma and three were microadenoma. Among the three patients with GH secreting adenomas, two improved clinically with normal serum GH level, one improved clinically with elevated serum GH levels postoperatively. Of the four patients with prolactinomas, all four improved clinically elevated with serum prolactin levels. Two patients developed postoperative complications; one was transient cerebrospinal fluid(CSF) leakage and the other was transient diabetes insipedus(DI). The use of the endoscope allowed close inspection of sella and parasellar structures as well as differentiation between tumor tissue and normal pituitary gland. Gross total removal was possible with the help of angled view of the telescope even in the cases of moderate supra-and parasellar extensions. Although from short and early experience, endoscopic endonasal approach seems to be a valuable and safe procedure for removing pituitary adenomas. With improved techniques and an accumulation in operative experience, endoscopic pituitary surgery will gain in importance and present new horizons in pituitary surgery.
Adenoma
;
Diagnosis
;
Endoscopes
;
Endoscopy
;
Humans
;
Pituitary Gland
;
Pituitary Neoplasms*
;
Postoperative Complications
;
Prolactin
;
Prolactinoma
;
Telescopes
7.A Ten-year Follow-up of a Case with Gastric Adenoma Accompanied with Gastritis Cystica Profunda Treated by Endoscopic Submucosal Dissection.
Jung Hee KIM ; Sung Yeol JANG ; Jeong Ah HWANG ; Sung Hae HA ; Won Gyu CHOI ; Ju Sang PARK ; Eun Mee HAN
The Korean Journal of Gastroenterology 2012;59(5):366-371
Gastritis cystica profunda (GCP) is an uncommon hyperplastic benign lesion, and histologically characterized by hyperplasia and cystic dilatation of the gastric glands extending into the submucosal layer. GCP usually occurs at a gastroenterostomy site, although it can occasionally be found in an unoperated stomach. GCP is thought to be a possible precancerous lesion, since a few early gastric cancers associated with it were reported. Herein, we report a case of gastric adenoma associated with GCP in an unoperated patient. The sizes of both the GCP and adenoma overlying it have increased during a 10 year follow-up period. Adenoma on the latest biopsy showed low grade dysplasia, and it was successfully treated by endoscopic submucosal dissection.
Adenoma/complications/*diagnosis/surgery
;
Aged, 80 and over
;
Female
;
Follow-Up Studies
;
Gastritis/complications/*diagnosis/ultrasonography
;
Gastroenterostomy
;
Humans
;
Precancerous Conditions
;
Stomach Neoplasms/complications/*diagnosis/surgery
;
Tomography, X-Ray Computed
8.Male infertility caused by pituitary adenoma.
National Journal of Andrology 2006;12(1):75-79
Pituitary adenoma is one of the important etiologies of male infertility. The early diagnosis of pituitary adenoma that caused infertility is not difficult with the help of modem incretion examination and imaging technique. The treatment focused on pituitary adenoma is no doubt the optimal choice of this kind of male infertility.
Growth Hormone-Secreting Pituitary Adenoma
;
complications
;
therapy
;
Humans
;
Infertility, Male
;
diagnosis
;
etiology
;
therapy
;
Male
;
Pituitary Neoplasms
;
complications
;
therapy
9.Symptomatic Hypocalcemia in Primary Hyperaldosteronism: A Case Report.
Sachin G PAI ; KN SHIVASHANKARA ; V PANDIT ; S SHESHADRI
Journal of Korean Medical Science 2009;24(6):1220-1223
The metabolic alterations caused by hyperaldosteronism are being increasingly recognized and have generated considerable interest among the medical fraternity. Hyperaldosteronism is suspected to have a pivotal role in the patho-physiology of congestive cardiac failure where it has been studied extensively. But its effects on calcium metabolism, parathyroid metabolism and renal handling of calcium are less well described. Recent experimental models have shed light into the roles played by previously unknown mechanisms in causing these metabolic alterations. We hereby report a case of primary hyperaldosteronism due to adrenal adenoma (Conn's syndrome) who presented with a myriad of clinical features including symptomatic hypocalcemia, significant weight loss along with uncontrolled hypertension for a prolonged period before eventually detected to have primary hyperaldosteronism. Surgical removal of the causative tumor resulted in prompt disappearance of all the symptoms and signs and regain of lost weight.
Adrenal Cortex Neoplasms/*complications/diagnosis/pathology/surgery
;
Adrenocortical Adenoma/*complications/diagnosis/pathology/surgery
;
Adult
;
Female
;
Humans
;
*Hyperaldosteronism/complications/etiology/physiopathology
;
Hypocalcemia/*etiology
;
Pregnancy
;
Treatment Outcome
10.Advances in Evaluation of Cognitive Impairment in Patients with Cushing's Disease.
Wei-Yu MAO ; Hui YOU ; Bing XING ; Hui-Juan ZHU ; Feng FENG
Acta Academiae Medicinae Sinicae 2016;38(6):735-738
Cushing's disease (CD) is a relatively rare disease,characterized by pathological hypercortisolism secondary to excessive adrenocorticotrophic hormone that is secreted by pituitary adrenocorticotrophic hormone adenoma or hyperplasia. In addition to the typical clinical symptoms such as moon face,buffalo hump,and central obesity,the CD patients may also experience mental disorders and cognitive dysfunction. This review mainly focuses on the cognitive state of CD patients,the mechanisms of cognitive impairment caused by high cortisol levels,and the imaging findings (especially magnetic resonance imaging) for the evaluation of cognitive functions.
Adenoma
;
complications
;
Cognition
;
Cognitive Dysfunction
;
complications
;
diagnosis
;
Cushing Syndrome
;
complications
;
Humans
;
Hyperplasia
;
Magnetic Resonance Imaging
;
Pituitary ACTH Hypersecretion
;
Pituitary Neoplasms
;
complications