Tubular apocrine adenoma and papillary eccrine adenoma are rare sweat gland neoplasms that appear as a small solitary lesion on the scalp or extremities, respectively. Although these lesions are thought to be distinct entities, there are enough similarities between them to group them under the term tubulopapillary hidradenoma or papillary tubular adenoma. We describe a case showing many tubular structures with papillary projection, syringocystadenoma-like structures, and eccrine hirocystoma-like structures in the axillary area. The term of papillary tubular adenoma or tubulopapillary hidradenoma may be prefered in this case.
Acrospiroma ; Adenoma* ; Extremities ; Scalp ; Sweat Gland Neoplasms

The clinical data of one patient with left ear temporal eccrine spiradenoma in our hospital were retrospectively analyzed. Eccrine adenoma, also known as the eccrine spiradenoma (eccrine spiradenoma, ES), a benign tumor derived from sweat glands, are typically single spherical or oval slow increases substantive or cystic nodules block, diameter of 1-2 cm, skin color or light blue. It's a rare case for young women, shorter onset time, more huge tumor, skin ulceration and exudate. This disease is a benign tumor, surgical resection could lead to a good result. It should be followed up after surgery.
Adenoma, Sweat Gland ; pathology ; Adolescent ; Ear Neoplasms ; pathology ; Female ; Humans ; Syringoma ; pathology ; Temporal Bone ; pathology

The discrimination of eccrine and apocrine neoplasms is still in dispute among researchers. To discriminate the differentiation of eccrine and apocrine neoplasms, immunohistochemical stainings with HMFG-1 and GCDFP-15 were performed on 12 specimens of eccrine and apocrine neoplasms, 3 of normal palmar tissues, and 3 of normal axillary tissues. The 12 cases of eccrine and apocrine neoplasms included 3 cases of syringoma, 2 cases of eccrine poroma, 2 cases of hidradenoma, 2 cases of apocrine hidrocystoma, 2 cases of syringocystadenoma papilliferum, and 1 case of spiradenoma. The 3 specimens of palmar tissue were used as the positive control of eccrine unit, and the 3 specimens of axillary tissue as that of apocrine unit. The results are as follows; HMFG-1 was positive in the cytoplasm and luminal surface of normal apocrine units, and also positive in those of eccrine units. Still more, HMFG-1 was documented as positive even in the eccrine poroma which is originated from eccrine unit. GCDFP-1 was positive in both normal eccrine and apocrine units, and glandular structure was stained stronger than ductal structure. In all of eccrine and apocrine neoplasms, syringoma, eccrine poroma, and spiradenoma which were known to differentiate to ductal structure were negative in GCDFP-15, but hidradenoma, apocrine hidrocystoma, and syringocystadenoma papilliferum which were known to differentiate to glandular structure were positive, partially. All these findings suggest that GCDFP-15 might be a useful marker for glandular differentiation rather than ductal differentiation, and both HMFG-1 and GCDFP-15 might not be useful to discriminate eccrine and apocrine neoplasms. Further intensive studies about normal eccrine and apocrine unit should be performed to determine if HMFG-1 could be used as a significant marker of apocrine unit, and it is necessary to develop new methods for the discrimination of eccrine and apocrine neoplasms.
Acrospiroma ; Cytoplasm ; Discrimination (Psychology) ; Dissent and Disputes ; Hidrocystoma ; Phenobarbital ; Poroma ; Syringoma

BACKGROUND: Various eccrine tumors are rather common diseases in clinicians. However, data on the clinicopathologic features of eccrine tumors in Korea are limited. OBJECTIVE: The purpose of this study was to investigate the clinicopathologic characteristics of eccrine tumors in Korea. METHODS: Two hundred and sixty five cases of eccrine tumors, seen from 2002 to 2004 in Korea, were retrospectively analyzed clinically and histopathologically. RESULTS: The most common eccrine tumors identified within Koreans were syringoma (61%), followed by eccrine poroma (13%), eccrine hidrocystoma (9%), and nodular hidradenoma (6%). Moreover, eccrine tumors were usually found to occur in middle-aged woman as multiple asymptomatic skin-colored papules. The most common site of occurrence was the face (45%), followed by the neck (9%), scalp (5%), foot (5%), abdomen (4%), and vulvar (3%). CONCLUSION: The results of this study will be useful and fundamental data on eccrine tumors for clinicians and pathologists.
Abdomen ; Acrospiroma ; Female ; Foot ; Hidrocystoma ; Humans ; Korea ; Neck ; Poroma ; Retrospective Studies ; Scalp ; Syringoma

BACKGROUND: Different distributions of cytokeratins (CKs) have been found in various layers of the epidermis and in the structure of cutaneous appendages. Benign tumors of the epidermis or cutaneous appendages usually retain the characteristic distribution of CKs of their origin. OBJECTIVE AND METHOD: To elucidate the nature and differentiation of various eccrine gland tumors, we performed immunohistochemical staining using a panel of monoclonal antibodies against CKs in a normal eccrire gland, syringoma, eccrine hidrocystoma, eccrine poroma and clear cell hidradenoma. The tissue distribution of various keratins in the normal eccrine gland was compared with that in varioas eccrine gland tumors. RESULTS: With regard to CKs expression, the results indicated that syringoma represents a tumor differentiating toward both the uppermost part of the dermal duct and the lower intraepidermal duct, and eccrine hidrocystoma represents a tumor differentiating toward the luminal cell of the dermal duct of the eccrine gland. Eccrine poroma cells seemed to be most closed related to the uppermost dermal duct of eccrine gland. We also found that analyse distribution of CKs was insufficient to elucidate the histogenesis of clear cell hidradenoma. CONCLUSION: Analysing CKs is helpful in the analysis of epidermal neoplasms with differentiation toward the eccrine gland.
Acrospiroma ; Antibodies, Monoclonal ; Eccrine Glands* ; Epidermis ; Hidrocystoma ; Keratins* ; Peptides* ; Phenobarbital ; Poroma ; Syringoma ; Tissue Distribution

BACKGROUND: Different distributions of cytokeratins (CKs) have been found in various layers of the epidermis and in the structure of cutaneous appendages. Benign tumors of the epidermis or cutaneous appendages usually retain the characteristic distribution of CKs of their origin. OBJECTIVE AND METHOD: To elucidate the nature and differentiation of various eccrine gland tumors, we performed immunohistochemical staining using a panel of monoclonal antibodies against CKs in a normal eccrire gland, syringoma, eccrine hidrocystoma, eccrine poroma and clear cell hidradenoma. The tissue distribution of various keratins in the normal eccrine gland was compared with that in varioas eccrine gland tumors. RESULTS: With regard to CKs expression, the results indicated that syringoma represents a tumor differentiating toward both the uppermost part of the dermal duct and the lower intraepidermal duct, and eccrine hidrocystoma represents a tumor differentiating toward the luminal cell of the dermal duct of the eccrine gland. Eccrine poroma cells seemed to be most closed related to the uppermost dermal duct of eccrine gland. We also found that analyse distribution of CKs was insufficient to elucidate the histogenesis of clear cell hidradenoma. CONCLUSION: Analysing CKs is helpful in the analysis of epidermal neoplasms with differentiation toward the eccrine gland.
Acrospiroma ; Antibodies, Monoclonal ; Eccrine Glands* ; Epidermis ; Hidrocystoma ; Keratins* ; Peptides* ; Phenobarbital ; Poroma ; Syringoma ; Tissue Distribution

BACKGROUND: CD44 is the principal cell surface receptor for hyaluronate and exists as multiple isoforms generated by the alternative splicing of up to 10 variant exons. Although certain isofroms may play a role in tumor progression and metastasis formation, the precise function and expression of the variant isoforms are less clear. Since on normal eccrine glands CD44 standard isoform(CD44s) is expressed only in eccrine coil secretory cells, it can be considered as a possible marker of this type of differentiation. However little is known about the expression of CD44 variant isofroms(CD44v) in eccrine gland tumors. OBJECTIVE: The purpose of this study was to investigate the immunohistochemical expression of different CD44 isoforms(CD44s, CD44v4, CD44v6) in the eccrine gland tumors. METHODS: Formalin-fixed and paraffin-embedded tissues from 2 cases of eccrine hidrocystoma, 5 cases of syringoma, 2 cases of eccrine poroma, 2 cases of syringofibroadenoma, 2 cases of nodular hidradenoma were immunolabelled with monoclonal antibody directed CD44s, CD44v4, and CD44v6. RESULTS: Except for syringofibroadenoma, the most tumors cells with eccrine ductal differentiation showed negative staining for CD44s, and positive staining for CD44v4 and CD44v6. Syringofibroadenoma exhibited positive staining for CD44s and CD44v4, but negative staining for CD44v6. Eccrine poroma showed negative staining for CD44s, positive staining for CD44v4, and variable intensity of staining for CD44v6 in different areas of the tumors. In case of nodular hidradenoma, small tubular lumina and clear cells were positive for CD44s. CONCLUSION: Our results suggest that CD44 isoforms can not be a useful marker for an eccrine gland tumor with specific differentiation, but its characteristic pattern of distribution might reflect the variety of functional roles of CD44 isoforms in tumorigenesis of eccrine gland tumors.
Acrospiroma ; Alternative Splicing ; Carcinogenesis ; Eccrine Glands* ; Exons ; Hidrocystoma ; Negative Staining ; Neoplasm Metastasis ; Poroma ; Protein Isoforms* ; Syringoma

Papillary eccrine adenoma is a rare benign sweat gland neoplasm. It occurs most often as a solitary nodule in women and is located predominantly on the distal portion of the extremities. This tumor is similar to tubular apocrine adenoma in histological and clinical aspects, so distinction of these tumors is still controversial. We report a case of two papillary eccrine adenomas developed on the left popliteal and calf area of a 58-year-old-man, this is the first report of the multiple papillary eccrine adenomas in Korea.
Adenoma* ; Extremities ; Female ; Humans ; Korea ; Sweat Gland Neoplasms

The papillary eccrine adenoma is a rare benign sweat gland neoplasm charscterized by potentislly locally aggressive clinical course. We report herein a case of papillsry eccrine adenoma in a 28-year-old female who presented single intradermal tumor on the right postauricular ares. Histopathological findings showed dilated ducts containing eosinophilic or keratinous materials and intraluminal papillary rowths.
Adenoma* ; Adult ; Eosinophils ; Female ; Humans ; Sweat Gland Neoplasms

Tumors occurring in the external auditory canal (EAC) are rare. In particular, tubular adenoma (TA) is an extremely rare sweat gland neoplasm occurring in the EAC and is generally considered as benign. Up to now, less than one hundred cases of TA have been reported in the English literature. In fact, a comprehensive review of literature shows that TA in the EAC has seldom been reported. Herein, we report a case of a 35-year-old man with TA that occured in the EAC, together with characteristic histopathological findings.
Adenoma ; Aminocaproic Acids ; Apocrine Glands ; Ear Canal ; Sweat Gland Neoplasms