Radiation therapy has been used as adjuvant therapy or primary treatment for inoperable, remnant or recurrent cancer. Many authors reported good palliation effect by external irradiation or interstitial therapy, but the report of intracavitary irradiation for recurrent, inoperable rectal cancer is very rare. We experienced a case of recurrent adenocarcinoma of rectum along fistula tract after laparotomy and postoperative radiotherapy who achieved very good palliation by intracavitary irradiation. Even though we have only good palliation without impressive survival improvement in this case, we hope that this technique may achieve good local control in other similar patients.
Adenocarcinoma* ; Fistula* ; Hope ; Humans ; Laparotomy ; Radiotherapy ; Rectal Neoplasms ; Rectum*

47 out of 56 cases of intact uterine cervix cancer treated by radiation at the Hanyang University Hospital were followed 18 months or more after treatment. (7 patients died before 18 months, 2 cases lost to follow-p). Age distribution reveal 5 cases in 30's, 18 cases in 40's, 17 cases in 50's, 7 cases in 60's. Histologically, all cases were squamous cell type except one case of adenocarcinoma. 1. 45 cases were treated by combined external Co-0 irradiation and intracavitary irradiation by Cs-37 small sources. 1 case was treated by external irradiation only, and 1 case by intracavitary only. 2. Rectal injuries were observed in 13 cased (27.6%), 4 cases in Grade 1, 8 cased in Grade 2 and 1 cases in Grade 3 which needed surgical management. 3. Average intervals of rectal injury and point A dose reveal 6 cases between 7000-999 rad and 6 cases between 8000-999 rad and 1 case above 9000 rad. Even though there is no direct relation between point A dose and rectal injury, it is expected that rectal injury increases as point A dose increase. 4. In the normal condition, rectal injury can't be attributed to one major cause. Radiation dose, small source distribution, general condition of patients, local anatomy of the individual patient, history of PID and previous surgery, all play complex roles.
Adenocarcinoma ; Age Distribution ; Cervix Uteri* ; Female ; Humans ; Radiotherapy*

Locally advanced or metastatic disease accounts for two thirds of total patients with pancreatic cancer. Patients with pancreatic cancer are assessed as resectable, potentially resectable (borderline) or unresectable according to pre-operative examinations. The chances of resectability may be enhanced by using neoadjuvant systemic chemotherapy, radiotherapy or both. This case report presents a locally advanced pancreatic adenocarcinoma that was identified to be unresectable during surgical exploration. After receiving concurrent chemoradiotherapy, the patient was re-evaluated, identified as unresectable and received gemcitabine maintenance chemotherapy. Herein, we report the case of a patient with unresectable locally advanced pancreatic adenocarcinoma who achieved a complete response lasting for more than 32 months after receiving concurrent chmoradiotherapy followed by gemcitabine maintenance chemotherapy.
Adenocarcinoma ; Chemoradiotherapy ; Drug Therapy* ; Humans ; Maintenance Chemotherapy ; Pancreatic Neoplasms* ; Radiotherapy

Locally advanced or metastatic disease accounts for two thirds of total patients with pancreatic cancer. Patients with pancreatic cancer are assessed as resectable, potentially resectable (borderline) or unresectable according to pre-operative examinations. The chances of resectability may be enhanced by using neoadjuvant systemic chemotherapy, radiotherapy or both. This case report presents a locally advanced pancreatic adenocarcinoma that was identified to be unresectable during surgical exploration. After receiving concurrent chemoradiotherapy, the patient was re-evaluated, identified as unresectable and received gemcitabine maintenance chemotherapy. Herein, we report the case of a patient with unresectable locally advanced pancreatic adenocarcinoma who achieved a complete response lasting for more than 32 months after receiving concurrent chmoradiotherapy followed by gemcitabine maintenance chemotherapy.
Adenocarcinoma ; Chemoradiotherapy ; Drug Therapy* ; Humans ; Maintenance Chemotherapy ; Pancreatic Neoplasms* ; Radiotherapy

We reported two patients with nasopharyngeal adenocarcinoma resected by using the exclusively endoscopic approach. Case reports and a review of the world literature concerning nasopharyngeal adenocarcinoma. The tumors were resected successfully via the exclusively endoscopic approach and no conversions to the conventional approach were necessary. The two patients were followed up for 26 and 18 months respectively, and no recurrence was noted without postoperative chemotherapy or radiotherapy. To the best of our knowledge, this is the first report of endoscopic resection of nasopharyngeal adenocarcinoma. Our experience revealed that not only for the early recurrent nasopharyngeal carcinoma, the exclusively endoscopic nasopharyngectomy can be expanded for the resection of selected nasopharyngeal adenocarcinoma.
Adenocarcinoma* ; Drug Therapy ; Endoscopes ; Humans ; Nasopharyngeal Neoplasms ; Radiotherapy ; Recurrence

Locally advanced prostate cancer (LAPC) is defined as histologically proven T3–4 prostatic adenocarcinoma. In this review, we define the individual roles of radiotherapy (RT), short-term (ST-) and long-term (LT-) androgen deprivation therapy (ADT), and their combination in multimodal therapy for LAPC. Despite limitations in comparing the clinical outcomes among published papers, in the present study, a trend of 10-year clinical outcomes was roughly estimated by calculating the average rates weighted by the cohort number. With RT alone, the following rates were estimated: 87% biochemical failure, 34% local failure (LF), 48% distant metastasis (DM), 38% overall survival (OS), and 27% disease-specific mortality (DSM). Those associated with ADT alone were 74% BCF, 54% OS, and 25% DSM, which appeared to be better than those of RT alone. The addition of ADT to RT produced a notable local and systemic effect, regardless of ST- or LT-ADT. The LF rate decreased from 34% with RT alone to 21% with ST-ADT and further to 15% with LT-ADT. The DM and DSM rates also showed a similar trend among RT alone, RT+ST-ADT, and RT+LT-ADT. The combination of RT+LT-ADT resulted in the best long-term clinical outcomes, indicating that both RT and ADT are important parts of multimodal therapy.
Adenocarcinoma ; Cohort Studies ; Mortality ; Neoplasm Metastasis ; Prostate* ; Prostatic Neoplasms* ; Radiotherapy*

Locally advanced prostate cancer (LAPC) is defined as histologically proven T3–4 prostatic adenocarcinoma. In this review, we define the individual roles of radiotherapy (RT), short-term (ST-) and long-term (LT-) androgen deprivation therapy (ADT), and their combination in multimodal therapy for LAPC. Despite limitations in comparing the clinical outcomes among published papers, in the present study, a trend of 10-year clinical outcomes was roughly estimated by calculating the average rates weighted by the cohort number. With RT alone, the following rates were estimated: 87% biochemical failure, 34% local failure (LF), 48% distant metastasis (DM), 38% overall survival (OS), and 27% disease-specific mortality (DSM). Those associated with ADT alone were 74% BCF, 54% OS, and 25% DSM, which appeared to be better than those of RT alone. The addition of ADT to RT produced a notable local and systemic effect, regardless of ST- or LT-ADT. The LF rate decreased from 34% with RT alone to 21% with ST-ADT and further to 15% with LT-ADT. The DM and DSM rates also showed a similar trend among RT alone, RT+ST-ADT, and RT+LT-ADT. The combination of RT+LT-ADT resulted in the best long-term clinical outcomes, indicating that both RT and ADT are important parts of multimodal therapy.
Adenocarcinoma ; Cohort Studies ; Mortality ; Neoplasm Metastasis ; Prostate* ; Prostatic Neoplasms* ; Radiotherapy*

OBJECTIVE: The authors aim to evaluate the overall trends of this cancer including incidence rates, distribution of stage, pathologic results, and methods of treatment during the last 11 years. METHODS: We obtained the data from the Annual Report of Gynecologic Cancer Registry Program in Korean from 1991-2002. Incidence rates were calculated using the number of population registered since 1992 from the website of National Statistical Office. RESULTS: Age-standardized incidence rate of endometrial cancer increased markedly for 9 years (p<0.05). The peak age of endometrial cancer shifted from the seventh to the sixth decade starting from 1997. The majority of endometrial cancer was diagnosed as stage I. Stage I contributed the major proportion from 1992 and it became to 63.3% of endometrial cancer in 2002. Adenocarcinomas were the main histologic type. The trend of treatment did not change which surgery is the main therapy followed by surgery and adjuvant radiotherapy. CONCLUSION: Recently, the incidence of endometrial cancer in Korean women increased annually during the last 9 years. Therefore, endometrial cancer may be given much more weight in the field of gynecologic cancer in Korea.
Adenocarcinoma ; Endometrial Neoplasms* ; Female ; Humans ; Incidence ; Korea ; Radiotherapy, Adjuvant

A case of adenocarcinoma developed initially in the left eye of a 25 year old Korean male was reported. Proptosis and visual disturbance were his chief complaints for about 18 months prior to visit our hospital. The tumor was radically removed, and then received radiotherapy with Co60 for 25 days. Metastasis occured in the skull bone and the right eye at 7 months and 8 months respectively, after the operation. The author was concluded that the poor prognosis is due to it's nature of malignancy and delayed surgical management.
Adenocarcinoma* ; Adult ; Exophthalmos ; Humans ; Male ; Neoplasm Metastasis ; Prognosis ; Radiotherapy ; Skull

To assess the effect of postoperative radiotherapy on tumor recurrence and patient survival, 133 patients who received adjuvant postoperative radiotherapy for adenocarcinoma of the rectum were retrospectively analyzed. Sixty-one percent of the patients were in stage C2 by Astler-Coller staging system. A significant statistical difference was noticed in failure rates for lymph node negative vs lymph node positive patients;26%(9/35) vs 50%(49/98). The incidence of local failure was found to be strongly dependent on the pathologic stages; with 9%(3/35) of recurrence in stage B and 21% (21-98) in stage C. Distant metastasis has occurred in 29% (38/133) of the patients; 2% (7/35) in stage B and 32%(31-98) in stage C. The actuarial Survival at 3 years for patients in stage B2, stage C1, and stage C2, were 78%, 47%, and 38%, respectively. In conclusion, the postoperative adjuvant radiotherapy for rectal carcinoma appears to reduce local recurrence significantly.
Adenocarcinoma ; Humans ; Incidence ; Lymph Nodes ; Neoplasm Metastasis ; Radiotherapy* ; Radiotherapy, Adjuvant ; Rectal Neoplasms* ; Rectum ; Recurrence ; Retrospective Studies