1.Aplastic Anemia Associated with Stomach.
Jee Sook HAHN ; Doe Young KIM ; Dong Ki NAM ; Young Sik LEE ; Sun Ju LEE ; Yun Woong KO ; Chang Hwan CHO
Yonsei Medical Journal 1988;29(3):263-269
Herein is presented a case of aplastic anemia associated with adenocarcinoma of the stomach which seem- ed to be coincidental. A 52 year-old man was admitted with a 3 year history of dyspnea. Three years previously, he was diagnosed as bone marrow hypoplasia and had been treated with oxymetholone for 1 year. After confirmation of aplastic anemia during the first admission, he was followed up with fluoxymesterone and steriods. One year later, he was readmitted with melena. Fibergastroscopy and an UGl study revealed a fungating mass on the antrum suggestive of stomach cancer. Following perioperative platelet transfusions and intensive supportive care, a subtotal gastrectomy was performed and there were no postoperative complications. Pathologic examinations disclosed a moderately well differentiated adenocarcinoma. This is the first report in Korea of adenocarcinoma of the stomach occurring in a patient with aplastic anemia. He survived 17.5 months after the surgery and 5.4 years after the onset of aplastic anemia. Gastrointestinal bleeding in aplastic anemia may be incorrectly ascribed to steriod use and overlooked, thus the need to fully investigate gastric pathology by endoscopy as well as radiology is streesed. In a patient with pancytopenia, the major surgical procedures are frequently evaded by both surgeons and internists due to the possibility of morbidity from bleeding and infection. In this case, intensive perioperative supportive care and surgery were combined to prolong the patient's survival time.
Adenocarcinoma/*complications/secondary/surgery
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Anemia, Aplastic/*complications/drug therapy
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Case Report
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Human
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Male
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Middle Age
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Oxymetholone/therapeutic use
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Stomach Neoplasms/*complications/surgery
2.Capecitabine and Oxaliplatin (XELOX) for the Treatment of Patients with Metastatic Gastric Cancer and Severe Liver Dysfunction.
Seung Jae HWANG ; Jong Won PARK ; Sehe Dong LEE ; Gyong Jung KIM ; Cheol Ho SIN ; Seung Hyun NAM ; Bong Seog KIM
The Korean Journal of Internal Medicine 2006;21(4):252-255
Gastric cancer patients with severe liver dysfunction secondary to hepatic metastases have limited treatment options. Most cytotoxic drugs have a narrow therapeutic index. Although both capecitabine and oxaliplatin have been well tolerated as single agents for patients with severe hepatic dysfunction, the combination of these drugs has not been investigated. We report here on a case of successful treatment of a patient suffering with severe liver dysfunction and metastatic gastric cancer; the patient was treated with a combination of capecitabine and oxaliplatin (XELOX). The initial bilirubin level of the patient was 10.9 mg/dL. After two cycles of treatment, his bilirubin level decreased to 2.1 mg/dL. He has experienced an excellent radiological response and he has received six cycles of XELOX chemotherapy. XELOX chemotherapy is feasible and it can be associated with positive outcomes for the patients suffering with metastatic gastric cancer and severe liver dysfunction.
Stomach Neoplasms/complications/*pathology/surgery
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Prodrugs
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Organoplatinum Compounds/*therapeutic use
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Middle Aged
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Male
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Liver Neoplasms/complications/*drug therapy/secondary
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Liver Function Tests
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Liver Failure/diagnosis/drug therapy/*etiology
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Humans
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Gastrectomy
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Follow-Up Studies
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Fluorouracil/*analogs & derivatives/therapeutic use
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Drug Therapy, Combination
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Deoxycytidine/*analogs & derivatives/therapeutic use
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Antineoplastic Agents/*therapeutic use
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Adenocarcinoma/complications/secondary/*therapy
3.RE: Metastasis of Gallbladder Adenocarcinoma to Bauhin's Valve: An Extremely Rare Cause of Intestinal Obstruction.
Edoardo VIRGILIO ; Valentina GIACCAGLIA ; Genoveffa BALDUCCI
Korean Journal of Radiology 2014;15(5):655-656
No abstract available.
Adenocarcinoma/*complications/*diagnosis/pathology
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Aged, 80 and over
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Colonoscopy
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Ethanol/therapeutic use
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Female
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Gallbladder Neoplasms/*complications/*diagnosis/pathology
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Humans
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Intestinal Obstruction/*etiology
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Liver Neoplasms/complications/drug therapy/secondary
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Tomography, X-Ray Computed