2.Mesonephric adenocarcinoma of the vaginal-urethral interspace.
Ying YAO ; Jinsong HAN ; Congrong LIU
Chinese Medical Journal 2014;127(5):984-985
Adenocarcinoma
;
diagnosis
;
surgery
;
Adult
;
Female
;
Humans
;
Mesonephroma
;
diagnosis
;
surgery
;
Urethral Neoplasms
;
diagnosis
;
surgery
;
Vaginal Neoplasms
;
diagnosis
;
surgery
3.Value of direct immunohistochemical staining in assisting intraoperative frozen diagnosis of bronchiolar adenoma.
Bo ZHENG ; Shuan Mei ZOU ; Lin YANG ; Xue Min XUE ; Chang Yuan GUO ; Long WANG ; Wen Chao LIU ; Zhao Zhao ZHOU ; Xin LIU ; Li Yan XUE
Chinese Journal of Pathology 2023;52(2):142-146
Objective: To explore the feasibility and application value of intraoperative direct immunohistochemical (IHC) staining in improving the diagnosis accuracy in difficult cases of bronchiolar adenoma (BA). Methods: Nineteen cases with single or multiple pulmonary ground-glass nodules or solid nodules indicated by imaging in Cancer Hospital of Chinese Academy of Medical Sciences from January to July 2021 and with difficulty in differential diagnosis at frozen HE sections were selected. In the experimental group, direct IHC staining of cytokeratin 5/6 (CK5/6) and p63 was performed on frozen sections to assist the differentiation of BA from in situ/micro-invasive adenocarcinoma/adenocarcinoma/invasive mucinous adenocarcinoma. In the control group, two pathologists performed routine frozen HE section diagnosis on these 19 cases. The diagnostic results of paraffin sections were used as the gold standard. The sensitivity and specificity of BA diagnosis, consistency with paraffin diagnosis and time used for frozen diagnosis were compared between the experimental group and the control group. Results: The basal cells of BA were highlighted by CK5/6 and p63 staining. There were no basal cells in the in situ/microinvasive adenocarcinoma/adenocarcinoma/invasive mucinous adenocarcinoma. In the experimental group, the sensitivity and specificity with aid of direct IHC staining for BA were 100% and 86.7%, respectively, and the Kappa value of frozen and paraffin diagnosis was 0.732, and these were significantly higher than those in the control group (P<0.05). The average time consumption in the experimental group (32.4 min) was only 7 min longer than that in the control group (25.4 min). Conclusions: Direct IHC staining can improve the accuracy of BA diagnosis intraoperatively and reduce the risk of misdiagnosis, but require significantly longer time. Thus frozen direct IHC staining should be restricted to cases with difficulty in differentiating benign from malignant diseases, especially when the surgical modalities differ based on the frozen diagnosis.
Humans
;
Paraffin
;
Sensitivity and Specificity
;
Adenocarcinoma in Situ
;
Adenoma/diagnosis*
;
Adenocarcinoma, Mucinous/surgery*
;
Frozen Sections/methods*
4.Diagnosis and treatment of the right ureter adenocarcinoma: report of one case.
Yu-gang LI ; An-yang WEI ; Da-peng YU
Journal of Southern Medical University 2006;26(5):583-583
Adenocarcinoma
;
diagnosis
;
surgery
;
Aged
;
Humans
;
Male
;
Treatment Outcome
;
Ureteral Neoplasms
;
diagnosis
;
surgery
5.Progress on the Study of Tumor Spread Through Air Spaces in the Clinicopathological Characteristics of Lung Adenocarcinoma and Its Influence on the Surgical Treatment and Prognosis of Lung Cancer.
Chinese Journal of Lung Cancer 2019;22(6):363-368
Tumor spread through air spaces (STAS) as a new pathological invasion mode is closely related to many clinicopathological factors. In lung adenocarcinoma, micropapillary and solid pathological subtypes are most related; STAS for early stage lung adenocarcinoma, surgical type of lobectomy seems to benefit better than sublobar resection, which may up-regulate the pathological stage of early lung cancer; Moreover, STAS is closely related to squamous cell carcinoma and other non-small cell lung cancer (NSCLC). In addition, intraoperative frozen-section pathological detection of STAS is difficult and controversial. STAS as an independent risk factor for tumor recurrence is also an important factor indicating poor prognosis. This paper reviews the research status and progress of STAS.
.
Adenocarcinoma of Lung
;
diagnosis
;
pathology
;
surgery
;
Animals
;
Humans
;
Lung Neoplasms
;
diagnosis
;
pathology
;
surgery
;
Neoplasm Invasiveness
;
Prognosis
6.A Case of Combined Hepatocellular-Cholangiocarcinoma with Underlying Schistosomiasis.
Chang Kyun HONG ; Jin Mo YANG ; Bong Koo KANG ; Jin Dong KIM ; Young Chul KIM ; U Im CHANG ; Jin Young YOO
The Korean Journal of Internal Medicine 2007;22(4):283-286
Combined hepatocellular-cholangiocarcinoma is a rare form of primary liver cancer showing features of both hepatocellular and biliary epithelial differentiation. We report here on a case with collision tumor, which apparently was the coincidental occurrence of both hepatocellular carcinoma and cholangiocarcinoma underlying schistosomiasis. A 39-year-old-Philippine female was transferred to our hospital for evaluation of a liver mass that was found on ultrasonography at a local hospital. HBsAg and Anti-HCV were negative and serum alpha-fetoprotein (AFP) level was normal. The tumor mass was histologically diagnosed as adenocarcinoma by sono-guided biopsy before the operation. Partial lobectomy was performed and we histologically identified the concurrent occurrence of hepatocellular carcinoma and cholangiocarcinoma, (a "collision type carcinoma").
Adenocarcinoma/diagnosis/pathology/surgery
;
Adult
;
Carcinoma, Hepatocellular/*diagnosis/pathology/surgery
;
Cholangiocarcinoma/*diagnosis/pathology/surgery
;
Female
;
Humans
;
Schistosomiasis/*physiopathology
7.Emphasis on diagnosis of thyroid carcinoma.
Chinese Journal of Pathology 2014;43(5):289-290
8.Survival rate of proximal and total gastrectomy in treatment of esophagogastric junction adenocarcinoma (Siewert II( Types).
Chao NAI ; Zhen LIU ; Xiao LIAN ; Shushang LIU ; Man GUO ; Shuao XIAO ; Jinqiang LIU ; Xuewen YANG ; Hongwei ZHANG
Chinese Journal of Gastrointestinal Surgery 2016;19(2):195-199
OBJECTIVETo compare the survival rate of proximal gastrectomy and total gastrectomy in the treatment of esophagogastric junction (EGJ) adenocarcinoma (Siewert II( types), and to provide reference for clinical choice.
METHODSA total of 533 patients with Siewet II( type EGJ adenocarcinoma were screened. All the patients underwent radical operations and were pathologically diagnosed as Siewet II( type EGJ adenocarcinoma in Xijing Hospital of Digestive Diseases from May 2008 to March 2014. These patients all had complete followed-up data. Finally, 234 patients were enrolled into the retrospective study, and divided into proximal gastrectomy group(117 patients) and total gastrectomy group (117 patients) based on the matching of age, sex, tumor size, TNM staging, and differentiation. The survival rate was compared between the two groups.
RESULTSIn proximal gastrectomy and total gastrectomy group, the overall 3-year survival rate was 65.6% and 62.6% respectively, and the overall 5-year survival rate was 53.8% and 44.5% respectively. No significant difference was found between the two groups (P=0.768). In subgroup analyses of 3-year survival rate between proximal gastrectomy group and total gastrectomy group, the results were as follows: 72.8% and 80.4% respectively (P=0.423) for tumor diameter ≤4 cm, 57.9% and 46.5% (P=0.239) for tumor diameter >4 cm, 83.3% and 83.3% (P=0.998) for high differentiated EGJ adenocarcinoma, 68.2% and 53.3% (P=0.270) for moderate differentiated EGJ adenocarcinoma, 56.1% and 69.6% (P=0.280) for poorly differentiated EGJ adenocarcinoma, 64.8% and 56.0% (P=0.451) for mucinous EGJ adenocarcinoma, 80.0% and 76.9% (P=0.912) for T1-2 stage EGJ adenocarcinoma, 64.3% and 60.4% (P=0.610) for T3 stage, 50.0% and 62.5% (P=0.953) for T4a stage, 92.3% and 100% (P=0.380) for stage I( EGJ adenocarcinoma, 79.6% and 66.3%(P=0.172) for stage II(, 42.6% and 49.5% (P=0.626) for stage I I(. All above differences between the two groups were not significant(all P>0.05).
CONCLUSIONProximal gastrectomy and total gastrectomy are comparable in terms of 3-year and 5-year survival rates.
Adenocarcinoma ; diagnosis ; surgery ; Esophageal Neoplasms ; diagnosis ; surgery ; Esophagogastric Junction ; pathology ; surgery ; Gastrectomy ; Humans ; Neoplasm Staging ; Retrospective Studies ; Stomach Neoplasms ; diagnosis ; surgery ; Survival Rate
10.Two Cases of Pancreatic Ductal Adenocarcinoma, Manifested as Solid Pseudopapillary Tumor and Intraductal Papillary Mucinous Neoplasm.
Dong Hyun KIM ; Jae Hee CHO ; Su Hyun LEE ; Hyun Ki KIM ; Seung Min BANG ; Si Young SONG ; Jae Bock CHUNG ; Seung Woo PARK
The Korean Journal of Gastroenterology 2008;51(2):142-146
Compared with other types of cancers, pancreatic cancer is one of the most dreadful malignancies and is fifth leading cause of cancer-related death in Korea. It is difficult to expect early diagnosis or improvement in prognosis due to lack of specific early symptoms and effective diagnostic methods. Whereas cystic neoplasm of the pancreas is a rare type of pancreatic tumor, surgical resection provides good prognosis because of its low possibility of local invasion or distant metastasis. In case of pancreatic cystic tumor, radiologic differentiation between benign and malignant lesions is crucial for the selection of appropriate treatment and the prediction of prognosis. And ductal adenocarcinoma of pancreas presenting in cystic form is an uncommon type of cystic tumor, making it extremely rare among all pancreatic malignancies. We report two cases of atypical pancreatic ductal adenocarcinoma presenting as solid pseudopapillary tumor and intraductal papillary mucinous neoplasm, respectively.
Adenocarcinoma, Mucinous/*diagnosis/surgery
;
Adenocarcinoma, Papillary/*diagnosis/surgery
;
Adult
;
Carcinoma, Pancreatic Ductal/*diagnosis/pathology/surgery
;
Female
;
Humans
;
Male
;
Middle Aged
;
Pancreatectomy
;
Pancreatic Neoplasms/*diagnosis/pathology/surgery
;
Tomography, X-Ray Computed