Adenocarcinoma, Sebaceous ; pathology ; Humans ; Male ; Middle Aged ; Parotid Neoplasms ; pathology

The Clinical Resemblance of the rare carcinoma of the meibomian gland to the relatively frequent chalazion should be kept in mind by anyone performing eye lid surgery. The author recently experienced two cases of Meibomian gland adenocarcinoma of upper lid. In the first case a 65-year old female visited our hospital in March, 1976 with a large mass in the right upper eyelid which had showed progressive enlargement of two years duration. A Diopsy was carried out and the histopathological examination revealed sebaceous adenocarcinoma. She was treated with local resection with full thickness containing normal tissue around the lesion of upper lid and reconstructive surgery for upper eyelid. A radiation therapy was performed with good result. In second case, a 80-year old female visited our hospital in Dec. 1975 with a large mass in the left upper eye lid which had showed progressive enlargement of one year duration. The tumor was resected and the histopathologic examination revealed sebaceous adenocarcinoma. A radiation therapy was performed with good result.
Adenocarcinoma* ; Adenocarcinoma, Sebaceous ; Aged ; Aged, 80 and over ; Chalazion ; Eyelids ; Female ; Humans ; Meibomian Glands*

Sebaceous carcinoma is a rare malignant tumor differentiated from the adnexal epithelium of sebaceous glands and forms less than 1% of all cutaneous malignancies. We present a case of a 93-year-old woman with a rapidly growing mass on the right cheek. Initial histiopathologic finding was basal cell carcinoma. The mass was widely excised and superficial parotidectomy was performed while preserving the facial nerve branches. The resulting defect was covered with a transposition flap from the ipsilateral posterior auricular area and the donor site was closed primarily. However, histopathologic examination of the excised mass showed a poorly differentiated sebaceous carcinoma with a clear resection margin. The diagnosis of sebaceous carcinoma can be difficult to make at initial presentation. This report describes a rare case of a rapidly growing extraocular sebaceous carcinoma, which resulted in a good treatment outcome, and provides a review of relevant literature.
Adenocarcinoma, Sebaceous ; Carcinoma, Basal Cell ; Cheek ; Diagnosis ; Epithelium ; Facial Nerve ; Female ; Humans ; Sebaceous Glands ; Tissue Donors ; Treatment Outcome

Sebaceous adenocarcinoma and squamous cell carcinoma of the conjunctiva are relatively uncommon diseases which usually develop in the upper eyelid and limbus. They spread to the adjacent bulbar and tarsal conjunctiva, cornea and sclera but their intraocular invasions are very rare. In our country, sebaceous adenocarcinoma or squamous cell carcinoma which occurred independently was reported, but no case of sebaceous aoenocarcinoma combined with squamous cell carcinoma of the conjunctiva was reported. We experienced a case of tumor at right upper tarsal conjunctiva in a 76-year-old Korean woman. Histopathologic examination revealed sebaceous adenocarcinoma combined with moderately differentiated squamous cell carcinoma.
Adenocarcinoma, Sebaceous* ; Aged ; Carcinoma, Squamous Cell* ; Conjunctiva* ; Cornea ; Eyelids ; Female ; Humans ; Sclera

Adenocarcinoma of the Meibomian gland is very rare but lethal tumors. Clinically, most of the time sebaceous gland carcinoma is mistaken for a chalazion. Any recurrent chalazion should be submitted for histologic study, and any chronic, recalcitrant, atypical blepharitis should be biopsied. The treatment of the choice is excisional biopsy and followed by radiation therapy. A 30 year old Korean male had a hard, nontender mass on the left upper lid which had recurred after chalazion surgery. The tumor was removed surgically as repair with modified Wheeler direct full halving procedure, and found to be a adenocarcinoma of the Meibomian gland histopathologically. There was no evidence of recurrence and metastasis to remote site a year after surgery with radiation therapy.
Adenocarcinoma* ; Adult ; Biopsy ; Blepharitis ; Chalazion ; Humans ; Male ; Meibomian Glands* ; Neoplasm Metastasis ; Recurrence ; Sebaceous Glands

Adenocarcinoma ; Adenoma ; Animals ; Communicable Diseases ; Fibroma ; Humans ; Incidence ; Lung ; Male ; Mammals ; Penis ; Rodentia ; Sebaceous Glands ; Uterus

The origin of Paget cells in extramammary Pagets disease is uncertain, however, some ultrastructural surveys revealed differentistion of Paget cells toward sweat gland apparatus. This is supported by recent immunohistochemical studies that Paget cells are irnmunohistochemically shown to react with antikeratin monoclonal antibodies specific to simple epithelia. In this siudy, seven cases of extramammary Pagets disease were immunohistochemically investigated with adenokeratin, carcinoembryonic antigen(CEA), involucrin by peroxidase-antiperoxidase(PAP) techniques. The results were as follow : l. Epidermis, hair follicies and sebaceous glands revealed negative immunoreacativity for adenokeratin in all cases. Sweat glands(6/7), Paget cells(6/7) and underlying adenocarcinoma revealed positive immunoreactivity for adenokeratin. 2. Epidermis, hair follicles and sebaceous glands(6/7) revealed negative immunoreactivity for CEA. Sweat glands, Paget cells and underlying adenocarcinoma revealed positive immunoreactivity for CEA in all cases. 3. Lower epidermis, sweat glands(6/7), Paget cells and underlying adenocarcinorna revealed negative irnmunoreactivity for involucrin. Upper epidermis, hair follicles and sebaceous glands(5/7) revealed positive immunoreactivity far involucrin. Based on these results, Paget cells of extramammary Pagets disease are considered to be derived from the sweat glands.
Adenocarcinoma ; Antibodies, Monoclonal ; Carcinoembryonic Antigen* ; Epidermis ; Hair ; Hair Follicle ; Paget Disease, Extramammary* ; Sebaceous Glands ; Sweat ; Sweat Glands

We report a sebaceous carcinoma confined to the corneoscleral limbus without involvement of the eyelid. A 60-year-old man, who showed multiple masses on the corneaoscleral limbus and limbal ulceration but with normal eyelids, underwent surgical en-bloc excision of the masses. Histopathologic examination revealed a sebaceous carcinoma. Three weeks after excision, multiple pagetoid recurrences were found along the bulbar conjunctiva 2 mm away from the limbus. After the application of topical mitomycin C, the pagetoid spread regressed completely. After a 2 year follow-up, no other local or systemic recurrences were observed. This report shows that the ulcerative mass which is confined to only the corneoscleral limbus may be a sebaceous carcinoma even without eyelid involvement. Topical mitomycin C may be effective for treating pagetoid spread of sebaceous carcinoma of limbal origin.
Adenocarcinoma, Sebaceous/*pathology/surgery ; Biological Dressings ; Diagnosis, Differential ; Eye Neoplasms/*pathology/surgery ; Follow-Up Studies ; Humans ; Limbus Corneae/*pathology ; Male ; Middle Aged ; *Neoplasm Recurrence, Local ; Ophthalmologic Surgical Procedures/methods ; Sebaceous Gland Neoplasms/*pathology/surgery

Muir-Torre syndrome (MTS) is an autosomal dominant genodermatosis first described in 1967 by Muir and in 1968 by Torre. It is characterized by the presence of at least one sebaceous gland tumor and the presence of a low-grade internal malignancy. The sebaceous neoplasia are typically adenomas, sebaceomas/sebaceous epitheliomas, or carcinomas. Most common internal malignancy is colorectal adenocarcinoma, but also neoplasia of the uterus, ovary and kidney may occur. Recent studies about genetic defect revealed MTS was caused by germline mutations in DNA mismatch repair genes and microsatellite instability. We report a case of MTS, multiple sebaceous adenomas with colorectal cancer in a 67-year-old male.
Adenocarcinoma ; Adenoma ; Aged ; Carcinoma ; Colorectal Neoplasms ; DNA Mismatch Repair ; Female ; Germ-Line Mutation ; Humans ; Kidney ; Male ; Microsatellite Instability ; Muir-Torre Syndrome* ; Ovary ; Sebaceous Glands ; Uterus