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The authors experienced three cases of cholangiocarcinoma associated with profuse mucin production. We intended to review and summarize the clinical features of these patients to emphasize the clinical importance of mucin-producing cholangiocarcinoma. All patients were female. Symptoms were mainly right upper quadrant pain and jaundice. Diagnosis was made by characteristic endoscopic retrograde cholangiographic findings and computed tomography. Bile ducts were dilatated and obstructive jaundice had developed as a result of the accumulation of mucin realeased by the tumor. Treatments were hepatic lobectomies for two intrahepatic cholangiocarcinoma patients and extrahepatic bile duct resection and hepaticojejunostomy for one patient. There was no postoperative complication. Pathologies were well differentiated papillary adenocarcinoma in two cases. Two patients are still living without recurrence for over three and four years respectively. One patient who had T4 lesion died of recurrence 38 months after operation. Conclusively, aggressive surgical treatment may be justified in the treatment of mucin hypersecreting cholangiocarcinoma even in advanced stage in view of the favorable outcome after radical operation. Further study is needed to clarify its biological behavior.
Adenocarcinoma, Papillary ; Bile Ducts ; Bile Ducts, Extrahepatic ; Cholangiocarcinoma* ; Diagnosis ; Female ; Humans ; Jaundice ; Jaundice, Obstructive* ; Mucins ; Pathology ; Postoperative Complications ; Recurrence

6.One case of papillary adenocarcinoma located in the back-end of nasal septum.

Jian ZANG ; Qian LIU ; Xuejun JIANG

Journal of Clinical Otorhinolaryngology Head and Neck Surgery 2015;29(3):281-282

Patients with nasopharyngeal foreign body sensation for 3 years, and had nasal obstruction in the past six months. electric nasopharyngoscopy: a irregular ellipse shape mass occupied in the nasopharynx, the mass surface is not smooth, with erosion ulcer and filthy secretions, the mass had a root in the back-end of nasal septum, and was adjacent to the bilateral round pillow. Sinus CT showed an irregular soft tissue shadow connected to the nasal septum backend in the nasopharynx, the size is about 2.8 cm X 3.5 cm, CT value is about 43 HU. Pathological examination: papillary adenocarcinoma.
Adenocarcinoma, Papillary ; diagnosis ; surgery ; Endoscopy ; Humans ; Nasal Obstruction ; Nasal Septum ; pathology ; Nasal Surgical Procedures ; Nasopharynx ; Tomography, X-Ray Computed

The goal of this study was to evaluate the cytomorphologic features of histologically confirmed uterine papillary serous carcinomas (UPSC) of the endometrium. We reviewed cervicovaginal smears from 12 patients with UPSC who had done their cervical smears at six months to a year earlier before the time of diagnosis; nine smears (75%) were diagnosed as positive for malignancy and three smears (25%) were diagnosed as negative. The cervical smears of patients with UPSC revealed frequent papillary clusters that were composed of large pleomorphic tumor cells with prominent nucleoli in a background of necrosis. Other findings revealed from the tests were relatively frequent single malignant cells and bare nuclei. Although the Pap smear is not a sensitive screening test for endometrial carcinoma, we could depend on it to reveal the cytologic features of UPSC which are fairly characteristic and reliable for a preoperative diagnosis of UPSC. Preoperative identification of this poor prognostic variant of endometrial carcinoma may influence the surgical management of these cases and the choice of adjuvant therapy.
Adenocarcinoma/diagnosis/pathology ; Adult ; Aged ; Carcinoma ; Carcinoma, Squamous Cell/diagnosis/pathology ; Cystadenocarcinoma, Papillary/*diagnosis/*pathology ; Cystadenocarcinoma, Serous/*diagnosis/*pathology ; Diagnosis, Differential ; Female ; Humans ; Middle Aged ; Necrosis ; Prognosis ; Uterine Neoplasms/*diagnosis/*pathology ; *Vaginal Smears

10.Mucoceles and mucocele-like lesions of breast.

Wen-tao YANG ; Da-li LI

Chinese Journal of Pathology 2009;38(9):633-636

1.Emphasis on diagnosis of thyroid carcinoma.

2.Problems in the diagnosis of thyroid papillary and follicular carcinoma.

3.Intraductal Papillary Mucinous Cholangiocarcinoma.

4.Ductal Adenocarcinoma Mimicking Intraductal Papillary Mucinous Neoplasm of the Pancreas.

5.Mucin-hypersecreting Cholangiocarcinoma causing Obstructive Jaundice.

6.One case of papillary adenocarcinoma located in the back-end of nasal septum.

7.Problems in pathologic diagnosis of thyroid follicular cell carcinoma.

8.Expression of Twist in papillary thyroid carcinomas and its roles in differential diagnosis.

9.Cytologic Findings of Cervicovaginal Smears in Women with Uterine Papillary Serous Carcinoma.

10.Mucoceles and mucocele-like lesions of breast.

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