Humans ; Adenocarcinoma, Mucinous/pathology* ; Stomach Neoplasms/pathology*

Adenocarcinoma, Mucinous ; pathology ; Carcinoma, Pancreatic Ductal ; pathology ; Humans ; Prognosis

Adenocarcinoma, Mucinous ; diagnosis ; pathology ; Cystadenocarcinoma, Mucinous ; diagnosis ; pathology ; Diagnosis, Differential ; Female ; Humans ; Ovarian Neoplasms ; pathology ; Ovary ; pathology

The growth pattern of 137 cancers of surgically removed stomach specimen were studied in relation to histological type and stromal reaction, namely, the degree of lymphocytic infiltration and fibrosis, and several characteristies were noted. Generally, stromal fibrosis increased more in the expanding type of growth of the cancer while the degree of lymphocytic infiltration did not. As an invasive growth pattern of cancer 5 directly affect on the prognosis of the stomach cancer, a graph was designed which can be used to help to predict the degree to which the cancer may be experted to have a greater tendency to expand locally or invade deeper. However, an increase in the number of metastatic lymph node parallels an increase in the size of the cancer.
Adenocarcinoma, Mucinous/pathology* ; Adenocarcinoma, Scirrhous/pathology* ; Carcinoma/pathology* ; Gastric Mucosa/pathology ; Human ; Lymphatic Metastasis ; Neoplasm Invasiveness ; Stomach Neoplasms/pathology*

Mucinous adenocarcinoma is a rare histologic type of gastric carcinoma. Most mucinous gastric carcinoma is diagnosed by histology after surgical resection. However, in this report, we preoperatively predicted the type of a tumor (mucinous type) from its characteristic endoscopic finding. An endoscopic examination showed a cauliflower-like mass on the upper body of the posterior wall. At first we could not find the mass because it was covered with a thick mucin-like substance. After gastric lavage and mucin aspiration we found a tumor mass which was surrounded with a characteristic mucin pool. Abdominal CT showed a 6 cm sized-mass connected with the gastric fundus. Total gastrectomy with esophagojejunostomy was performed. The pathology of the tumor proved to be a mucinous adenocarcinoma.
Adenocarcinoma* ; Adenocarcinoma, Mucinous ; Gastrectomy ; Gastric Fundus ; Gastric Lavage ; Gastric Mucins* ; Mucins* ; Pathology ; Tomography, X-Ray Computed

Adenocarcinoma ; classification ; pathology ; Adenocarcinoma, Mucinous ; pathology ; Biopsy ; Carcinoma, Ductal ; pathology ; Humans ; Male ; Neoplasm Grading ; methods ; standards ; Prostatic Neoplasms ; classification ; pathology

BACKGROUND: Invasive mucinous adenocarcinoma (IMA) was a rare and specific type of lung adenocarcinoma, which was often characterized by fewer lymphatic metastases. Therefore, it was difficult to evaluate the prognosis of these tumors based on the existing tumor-node-metastasis (TNM) staging. So, this study aimed to develop Nomograms to predict outcomes of patients with pathologic N0 in resected IMA. METHODS: According to the inclusion criteria and exclusion criteria, IMA patients with pathologic N0 in The Affiliated Lihuili Hospital of Ningbo University (training cohort, n=78) and Ningbo No.2 Hospital (validation cohort, n=66) were reviewed between July 2012 and May 2017. The prognostic value of the clinicopathological features in the training cohort was analyzed and prognostic prediction models were established, and the performances of models were evaluated. Finally, the validation cohort data was put in for external validation. RESULTS: Univariate analysis showed that pneumonic type, larger tumor size, mixed mucinous/non-mucinous component, and higher overall stage were significant influence factors of 5-year progression-free survival (PFS) and overall survival (OS). Multivariate analysis further indicated that type of imaging, tumor size, mucinous component were the independent prognostic factors for poor 5-year PFS and OS. Moreover, the 5-year PFS and OS rates were 62.82% and 75.64%, respectively. In subgroups, the survival analysis also showed that the pneumonic type and mixed mucinous/non-mucinous patients had significantly poorer 5-year PFS and OS compared with solitary type and pure mucinous patients, respectively. The C-index of Nomograms with 5-year PFS and OS were 0.815 (95%CI: 0.741-0.889) and 0.767 (95%CI: 0.669-0.865). The calibration curve and decision curve analysis (DCA) of both models showed good predictive performances in both cohorts. CONCLUSIONS The Nomograms based on clinicopathological characteristics in a certain extent, can be used as an effective prognostic tool for patients with pathologic N0 after IMA resection.
Humans ; Prognosis ; Lung Neoplasms/pathology* ; Adenocarcinoma, Mucinous/pathology* ; Adenocarcinoma of Lung/pathology* ; Neoplasm Staging ; Lung/pathology* ; Retrospective Studies

Gastric mucinous adenocarcinoma is a rare histologic subtype of gastric cancers. It has been reported that the gross or endoscopic finding of mucinous gastric carcinoma is commonly described as a ulcerative or fungating mass in common. There has been controversy over the prognosis and the gross morphology of mucinous gastric adenocarcinoma. We report a case of mucinous gastric adenocarcinoma presenting as a submucosal tumor.
Adenocarcinoma, Mucinous/diagnosis/*pathology ; English Abstract ; Female ; Humans ; Middle Aged ; Stomach/pathology ; Stomach Neoplasms/diagnosis/*pathology

OBJECTIVETo assess recent trends and prognostic features in the treatment of pure mucinous carcinoma (PMC) of the breast.

METHODSFifty-six patients diagnosed with PMC of the breast in our hospital from December 1982 to June 2008 were included. We evaluated the general information and tumor characteristics of the patients, examined the relationship between these factors and prognosis. Fisher's exact test was applied to analyze tumor characteristics.

RESULTSThe mean age of the patients was 53.7 years. The majority of the patients presented with early stage disease. Tumor size was found not a significant prognostic factor in this study. Mean follow-up period was 39 months and no breast cancer-related deaths were identified in the patient cohort.

CONCLUSIONSPMC of the breast has a favorable prognosis. Tumor size does not appear to significantly impact survival.

OBJECTIVETo study the clinical manifestations, pathological characteristics and treatment methods of prostate cancer with five different histological features.

METHODSWe reported 1 case of prostate cancer with five different histological features and further analyzed the diagnosis, pathology and treatment of the disease by reviewing the relevant literature.

RESULTSThe patient was an 84-year-old male, admitted due to difficult urination and dribbling urine for 1 year, hematuria for 8 months and deterioration for 2 weeks. Prostate cancer was indicated by rectal examination, ultrasonography, CT, MRI and PSA, and confirmed by biopsy. Considering the general condition of the patient, we performed electrotransurethral resection under epidural anesthesia to alleviate his urinary symptoms and remove suspected tumor tissues. Postoperative pathology showed the case to be prostate adenocarcinoma, histologically characterized by cribriform carcinoma, acinar carcinoma, diffuse invasive carcinoma, ductal carcinoma, and mucinous adenocarcinoma, with a Gleason score of 9. Bicalutamide and goserelin were administered postoperatively. Systemic metastasis occurred 10 months later, and the patient died 1 year after the operation.

CONCLUSIONProstate cancer with five different histological features is extremely rare. Its early diagnosis is difficult and mainly depends on pathological and immunohistochemical examinations, and radical prostatectomy can be considered for its treatment.