Mucinous adenocarcinomas of the anal region constitute only 2% of anal cancer and adenocarcinoma developing in a chronic tuberculous anal fistula is extremely rare. In most cases, its origin is difficult to ascertain because the primary sites have already been destroyed before any diagnosis of malignancy is made. We experienced a case of perianal adcnocarcinoma developing in chronic tuberculous anal fistula, which was treated by abdominoperineal resection with preoperative chemo-irradiation. We reported a case and reviewed the related literatures.
Adenocarcinoma* ; Adenocarcinoma, Mucinous ; Anus Neoplasms ; Diagnosis ; Rectal Fistula*

Malignant transformation of mature cystic teratoma (MCT) is an uncommon complication occuring in approximately 1-3%. Any of the constituent tissues of a teratoma has the potential to undergo malignant transformation; squamous cell carcinoma is the most commonly associated cancer, however, adenocarcinomas or carcinoid tumors arising in mature cystic teratoma are uncommon, especially simultaneously. We present an unusual case of postmenopausal women having mucinous adenocarcinoma and strumal carcinoid tumor simultaneously arising in one of bilateral mature cystic teratoma of the ovary. We suggest malignant transformation of MCT should be treated according to the management of the worst histologic diagnosis of the transformations if there are 2 or more malignancies are arised in MCT of the ovary.
Adenocarcinoma ; Adenocarcinoma, Mucinous* ; Carcinoid Tumor* ; Carcinoma, Squamous Cell ; Cystadenocarcinoma, Mucinous ; Diagnosis ; Female ; Humans ; Mucins* ; Ovary* ; Teratoma*

Signet ring cell carcinoma is a rare type of mucinous adenocarcinoma of the uterine cervix. To the best of our knowledge, there is no report on cytologic findings of primary signet ring cell carcinoma of the uterine cervix in the literature. Recently, we experienced two cases of signet ring cell carcinoma of the uterine cervix. The finding of characteristic signet ring cells on cervicovaginal smear led to the diagnosis of signet ring cell carcinoma. However, primary signet ring cell carcinoma could not be cytologically distinguished from more common metastatic tumor. Therefore, diagnosis rests upon the recognition of signet ring cells and the absence of signet ring cell carcinoma elsewhere.
Adenocarcinoma, Mucinous ; Carcinoma, Signet Ring Cell* ; Cervix Uteri* ; Diagnosis ; Female

To determine the distinction of primary ovarian carcinoma from metastatic ovariancarcinoma, the author studied total 40 cases of malignant tumors(13 primary ovarian carcinomas:7 serous, 4 mucinous, and 2 endometrioid, 7 metastatic ovarian adenocarcinomas,10 gastric adenocarcinomas and 10 colonic adenocarcinomas) using primary antibody to CEA,CK7, CK20 and CK18. The results were summerised as follows: The expression of CK7was demonstrated in all(7) serous and 3 out of 4 mucinous adenocarcinoma, and 1 out of10 each gastric and colonic adenocarcinoma. The CK20 positivity was seen in 4 out of 10cases of colonic adenocarcinoma and 3 out of 7 cases of metastatic adenocarcinoma. Allprimary ovarian carcinoma and gastric adenocarcinoma were negative for CK20 except forfocal positivity in only 1 ovarian mucinous adenocarcinoma. All types of serous andendometrioid adenocarcinoma were negative for CEA. But, the vast majority of mucinousadenocarcinoma, metastatic adenocarcinoma, gastric and colonic adenocarcinoma were positivefor CEA. The CK18 may not be helpful to differentiate the primay or metastatic carcinomabecause all cases examined were positive for CK18 except for 1 ovarian mucinous carcinoma.Immunostainning for CK7 may be helpful on differential diagnosis of primary andmetastatic ovarian carcinoma, especially mucinous adenocarcinoma and metastatic gastric andcolonic adenocarcinoma. The CK20 may be a useful marker for differential diagosis inprimary and metastatic ovarian carcinomas. The CEA may be of value on differential diagnosisof mucinous and nonmucinous(serous and endomerioid) ovarian carcinomas, and metastaticcolonic adenocarcinoma and endometrioid carcinoma.In conclusion, immunohistochemical study for CEA, CK7, and CK20 may be helpful indifferential diagnosis between primary and metastatic ovarian carcinoma.
Adenocarcinoma ; Adenocarcinoma, Mucinous ; Colon ; Diagnosis ; Diagnosis, Differential* ; Female ; Immunohistochemistry ; Mucins ; Neoplasm Metastasis ; Ovary

Adenocarcinoma, Mucinous ; diagnosis ; pathology ; Cystadenocarcinoma, Mucinous ; diagnosis ; pathology ; Diagnosis, Differential ; Female ; Humans ; Ovarian Neoplasms ; pathology ; Ovary ; pathology

Primary cutaneous mucinous carcinoma (PCMC) is a rare malignant tumor of eccrine origin. Clinically, the carcinoma presents as a solitary, slow growing, and painless nodule. For this reason, this tumor is often considered to be a benign mass in the preoperative setting. The lesion is, however, malignant in nature and has a tendency for local recurrence and infrequent metastasis. Wide local excision is the treatment of choice. However, few reports exist with information regarding surgical margins and clinical outcomes. Herein, we report a case of PCMC excised with a narrow surgical margin and review the relevant literature. A 49-year-old man presented with a small cutaneous nodule of the right cheek. The mass was excised without any margin, but pathologic examination revealed histology of mucinous carcinoma. Because of this, the operative site was re-excised with a 5-mm margin, and the wound was closed using a V-Y advancement flap. Systemic work-up did not reveal other potential metastatic primary, for a final diagnosis of PCMC. We report this case of PCMC, treated with relatively narrow margin in a patient with good prognostic factors.
Adenocarcinoma ; Adenocarcinoma, Mucinous* ; Cheek ; Diagnosis ; Humans ; Middle Aged ; Mucins* ; Neoplasm Metastasis ; Recurrence ; Wounds and Injuries

PURPOSE: To evaluate CT findings of mucinous adenocarcinoma in the gastrointestinal tract. MATERIALS AND METHODS : CT scans of 24 gastric and five colorectal mucinous adenocarcinomas, proven by histology, were retrospectively analysed; the patients consisted of 18 men and 11 women (age range, 27-76; mean, 59). CT findings were analysed, with emphasis on : (a) tumor size and maximal wall thickness ; (b) the presence of a low attenuation area, suggestive of a mucin poll within the tumor ; (c) the presence, shape and location of calcification, and (d) correlation between primary tumor (T) staging and CT findings. RESULTS: The mean tumorsize of gastric mucinous adenocarcinoma was 8.2cm (range, 1.4 - 17cm) and the mean maximal wall thickness was2.3cm (range, 1-4.5cm). Low attenuation areas on enhanced CT were seen in 12 cases (50%). Mottled, punctate, diffuse calcifications were demonstrated in nine cases(38%), and were located in low attenuation areas in eight cases. The T staging could be determined in 22 cases. Of there, low attenuation areas were demonstrated in tencases and calcification in seven. Of those ten cases with low atteuation area T staging was T2 in two cases, T3 intwo, and T4 in six. Of the cases showing calcification, T staging was T3 in one case and T4 in six. The mean sizeof colorectal mucinous adenocarcinoma was 6cm(range, 3-13cm) and the mean maximal wall thickness was 3.6cm (range,1.5-7cm). Low attenuation area were seen in three cases. Mottled calcification within the low sttenuation was detected in one case. The T staging of three cases which showed a low attenuation area was T3 in tow cases and T4in one case. One case with calcification was T3 stage. CONCLUSION: The CT finding of mucinous adenocarcinoma inthe gastrointestinal tract was a relatively thick-walled mass containing an area of low attenuation or calcification. Although calcification is believed to be a pathognomonic finding for the specific diagnosis of mucinous adenocarcinoma, a low attenuation area may be an important CT finding because it can be detected at lower T staging and more frequently.
Adenocarcinoma ; Adenocarcinoma, Mucinous* ; Diagnosis ; Female ; Gastric Mucins ; Gastrointestinal Tract* ; Humans ; Male ; Mucins* ; Tomography, X-Ray Computed

Objective: To explore the feasibility and application value of intraoperative direct immunohistochemical (IHC) staining in improving the diagnosis accuracy in difficult cases of bronchiolar adenoma (BA). Methods: Nineteen cases with single or multiple pulmonary ground-glass nodules or solid nodules indicated by imaging in Cancer Hospital of Chinese Academy of Medical Sciences from January to July 2021 and with difficulty in differential diagnosis at frozen HE sections were selected. In the experimental group, direct IHC staining of cytokeratin 5/6 (CK5/6) and p63 was performed on frozen sections to assist the differentiation of BA from in situ/micro-invasive adenocarcinoma/adenocarcinoma/invasive mucinous adenocarcinoma. In the control group, two pathologists performed routine frozen HE section diagnosis on these 19 cases. The diagnostic results of paraffin sections were used as the gold standard. The sensitivity and specificity of BA diagnosis, consistency with paraffin diagnosis and time used for frozen diagnosis were compared between the experimental group and the control group. Results: The basal cells of BA were highlighted by CK5/6 and p63 staining. There were no basal cells in the in situ/microinvasive adenocarcinoma/adenocarcinoma/invasive mucinous adenocarcinoma. In the experimental group, the sensitivity and specificity with aid of direct IHC staining for BA were 100% and 86.7%, respectively, and the Kappa value of frozen and paraffin diagnosis was 0.732, and these were significantly higher than those in the control group (P<0.05). The average time consumption in the experimental group (32.4 min) was only 7 min longer than that in the control group (25.4 min). Conclusions: Direct IHC staining can improve the accuracy of BA diagnosis intraoperatively and reduce the risk of misdiagnosis, but require significantly longer time. Thus frozen direct IHC staining should be restricted to cases with difficulty in differentiating benign from malignant diseases, especially when the surgical modalities differ based on the frozen diagnosis.
Humans ; Paraffin ; Sensitivity and Specificity ; Adenocarcinoma in Situ ; Adenoma/diagnosis* ; Adenocarcinoma, Mucinous/surgery* ; Frozen Sections/methods*

This study presents the cytologic features of peritoneal washings, with particular emphasis on the cytologic discrimination among serous, mucinous, and endometrioid adenocarcinoma of the ovary. We selected histologically confirmed 27 cases of peritoneal washing : 8 cases of serous cystadenocarcinomas, 5 cases of mucinous cystadenocarcinomas, and 14 cases of endometrioid adenocarcinomas. The most frequent cytologic pattern of three tumors was clusters. Ball pattern was found in serous cystadenocarcinoma(36%) and acinar pattern in endometrioid adenocarcinoma (36%). Mucinous adenocarcinoma showed mucoid background(100%) and endometrioid adenocarcinoma revealed inflammatory background(43%). The cytoplasmic vacuoles were noted in 80%, 13%, and 43% of mucinous, serous, and endometrioid adenocarcinoma, respectively. The endometrioid adenocarcinoma showed prominent nucleoli(64%). In conclusion, the cytologic findings of mucinous cystadenocarcinoma were different from that of serous and endometrioid carcinomas, such as mucoid background, abundant cytoplasm with vacuolated cytoplasm, and peripherally located cytoplasm. Although endometrioid carcinoma showed acinar pattern and prominent nucleoli, the differential diagnosis between serous cystadenocarcinoma and endometrioid adenocarcinoma in peritoneal washing cytology was not always possible.
Adenocarcinoma, Mucinous ; Carcinoma, Endometrioid* ; Cystadenocarcinoma, Mucinous ; Cystadenocarcinoma, Serous ; Cytoplasm ; Diagnosis, Differential* ; Discrimination (Psychology) ; Female ; Mucins* ; Ovary ; Vacuoles

Gastric mucinous adenocarcinoma is a rare histologic subtype of gastric cancers. It has been reported that the gross or endoscopic finding of mucinous gastric carcinoma is commonly described as a ulcerative or fungating mass in common. There has been controversy over the prognosis and the gross morphology of mucinous gastric adenocarcinoma. We report a case of mucinous gastric adenocarcinoma presenting as a submucosal tumor.
Adenocarcinoma, Mucinous/diagnosis/*pathology ; English Abstract ; Female ; Humans ; Middle Aged ; Stomach/pathology ; Stomach Neoplasms/diagnosis/*pathology