1.Noninvasive follicular thyroid neoplasm with papillary-like nuclear features and the risk of malignancy in thyroid cytology: Data from Singapore.
Bryan Wei Wen LEE ; Manish Mahadeorao BUNDELE ; Rong TAN ; Ernest Wei Zhong FU ; Agnes Siqi CHEW ; Junice Shi Hui WONG ; Caroline Ching Hsia SIEW ; Brenda Su Ping LIM ; Rinkoo DALAN ; Ming Yann LIM ; Yijin Jereme GAN ; Hao LI
Annals of the Academy of Medicine, Singapore 2021;50(12):903-910
INTRODUCTION:
The impact of noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) on the risk of malignancy (ROM) in fine-needle aspiration cytology (FNAC) per The Bethesda System for Reporting Thyroid Cytopathology has not been well reported in Singapore.
METHODS:
We retrospectively identified 821 thyroid nodules with preoperative FNAC from 788 patients out of 1,279 consecutive thyroidectomies performed between January 2010 and August 2016 in a tertiary general hospital in Singapore. Possible cases of NIFTP were reviewed for reclassification and the impact of NIFTP on ROM was analysed.
RESULTS:
The incidence of NIFTP was 1.2% (10 out of 821). If NIFTP is considered benign, ROM in Bethesda I through VI were 8.6%, 3.5%, 26.3%, 20.0%, 87.7%, 97.0% versus 8.6%, 4.2%, 28.1%, 26.7%, 89.2% and 100% if NIFTP is considered malignant. Eight patients with NIFTP had follow-up of 15 to 110 months. One had possible rib metastasis as evidenced by I131 uptake but remained free of structural or biochemical disease during a follow-up period of 110 months. None had lymph node metastasis at presentation, nor locoregional or distant recurrence.
CONCLUSION
Classifying NIFTP as benign decreased ROM in Bethesda II through VI, but the benignity of NIFTP requires more prospective studies to ascertain. The impact of NIFTP on ROM in our institution also appears to be lower than that reported in the Western studies.
Adenocarcinoma, Follicular/epidemiology*
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Humans
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Prospective Studies
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Retrospective Studies
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Singapore/epidemiology*
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Thyroid Neoplasms/epidemiology*
2.Clinical implications of follicular and Hurthle cell carcinoma in an iodine-sufficient area.
The Korean Journal of Internal Medicine 2014;29(3):305-306
No abstract available.
Adenocarcinoma, Follicular/*epidemiology
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*Diet
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Female
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Humans
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*Iodine
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Male
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*Nutritional Status
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Thyroid Neoplasms/*epidemiology
4.Time Trends Analysis of Characteristics of Patients with Thyroid Cancer in a Single Medical Center.
Hyung Seo JUNG ; Min Ji JEON ; Dong Eun SONG ; Suck Joon HONG ; Won Gu KIM ; Tae Yong KIM ; Young Kee SHONG ; Won Bae KIM
Journal of Korean Thyroid Association 2014;7(2):159-166
BACKGROUND AND OBJECTIVES: The incidence of thyroid cancer is increasing worldwide. The increase in the frequency of screening tests may have led to an over-detection of small thyroid cancers. The Korean Thyroid Association (KTA) discourages the find needle aspiration of thyroid nodules < or =0.5 cm. The aim of this study was to evaluate time trends of characteristics of thyroid cancer patients in a single medical center. MATERIALS AND METHODS: This study included 15,465 patients who underwent operation due to thyroid cancer from 1995 to 2012. Data on age, gender of patients and histology, clinical stage of the thyroid cancer were reviewed retrospectively. RESULTS: New thyroid cancer cases have dramatically increased and papillary thyroid carcinoma (PTC) accounted for a major part of this increase. PTCs were accounted for 98% of all thyroid cancer surgeries in 2012 and 79% in 1995. The proportion of PTCs < or =0.5 cm has increased from 1% in 1995 to 32% in 2009 and then slightly decreased afterward. The peak age of patients with PTC has increased from 40 years in 1995-2000 to 55 years in 2006-2012. The proportion of small follicular thyroid carcinomas and medullary thyroid carcinomas (< or =1.0 cm) also steadily increased during study periods. CONCLUSION: Thyroid cancers became smaller but, increase of very small PTCs stopped after 2010, in which the KTA guidelines were introduced. These findings suggest that the increasing incidence of thyroid cancer in Korea might be due to the over-detection of small thyroid cancers.
Adenocarcinoma, Follicular
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Epidemiology
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Humans
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Incidence
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Korea
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Mass Screening
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Needles
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Retrospective Studies
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Thyroid Gland
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Thyroid Neoplasms*
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Thyroid Nodule
5.Analysis of variation trends of thyroid cancer treated in Tianjin Cancer Hospital form 1954 to 2009.
Song-Feng WEI ; Ming GAO ; Bi-Yun QIAN ; Yi-Gong LI ; Yan ZHANG ; Wen-Yuan CHEN ; Xiang-Qian ZHENG ; Xiao-Long LI ; Yang YU ; Yong CUI
Chinese Journal of Oncology 2011;33(8):613-615
OBJECTIVETo investigate and analyze the variation trends in the pathological composition of thyroid cancer patients treated in Tianjin Cancer Hospital from 1954 to 2009.
METHODSTo retrospectively analyze the incidence and clinical features of different pathological types of thyroid cancers in 4342 patients between different time periods from 1954 to 2009.
RESULTSIn the four main pathological types of thyroid cancers, the component ratio of papillary thyroid cancer in every period was 68.1%, 78.3%, 81.3%, 82.1%, 85.8%, respectively, while the morbidity of patients with papillary thyroid carcinoma concurrent with Hashimoto's thyroiditis was increased, so was the proportion of tumors in diameter < or = 2 cm. The proportion of follicular thyroid carcinoma and anaplastic thyroid carcinoma was decreasing accordingly; however, the proportion of medullary thyroid carcinoma did not change significantly.
CONCLUSIONSThe pathological classification of the thyroid carcinoma patients has significant changes in the 4342 cases treated in our Hospital from 1954 to 2009. The proportion of papillary carcinoma is increased, while that of follicular carcinoma and anaplastic carcinoma is decreased. The reasons might attribute to the improved level of consultations and iodized diet or other factors.
Adenocarcinoma, Follicular ; epidemiology ; pathology ; Carcinoma ; epidemiology ; pathology ; Carcinoma, Medullary ; epidemiology ; pathology ; Carcinoma, Papillary ; epidemiology ; pathology ; China ; epidemiology ; Female ; Hashimoto Disease ; complications ; epidemiology ; pathology ; Humans ; Incidence ; Male ; Retrospective Studies ; Thyroid Neoplasms ; complications ; epidemiology ; pathology ; Tumor Burden
6.Advances in poorly differentiated thyroid carcinoma.
Jian SUN ; Di YANG ; Quan-cai CUI
Chinese Journal of Pathology 2011;40(12):850-853
Adenocarcinoma, Follicular
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epidemiology
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genetics
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metabolism
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pathology
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Carcinoma, Papillary
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pathology
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DNA-Binding Proteins
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metabolism
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Diagnosis, Differential
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Genes, ras
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genetics
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Humans
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Point Mutation
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Prognosis
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Thyroglobulin
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metabolism
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Thyroid Neoplasms
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epidemiology
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genetics
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metabolism
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pathology
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Transcription Factors
7.Follicular and Hurthle cell carcinoma of the thyroid in iodine-sufficient area: retrospective analysis of Korean multicenter data.
Won Gu KIM ; Tae Yong KIM ; Tae Hyuk KIM ; Hye Won JANG ; Young Suk JO ; Young Joo PARK ; Sun Wook KIM ; Won Bae KIM ; Minho SHONG ; Do Joon PARK ; Jae Hoon CHUNG ; Young Kee SHONG ; Bo Youn CHO
The Korean Journal of Internal Medicine 2014;29(3):325-333
BACKGROUND/AIMS: Follicular thyroid carcinoma (FTC) and Hurthle cell carcinoma (HCC) of the thyroid are relatively uncommon thyroid malignancies in iodine-sufficient areas. In this study we evaluated the clinical behavior, prognostic factors and treatment outcomes of FTC and HCC in Korea. METHODS: This multicenter study included 483 patients with FTC and 80 patients with HCC who underwent an initial surgery between 1995 and 2006 in one of the four tertiary referral hospitals in Korea. We evaluated clinicopathological factors associated with distant metastases and recurrence during a median of 6 years of follow-up. RESULTS: HCC patients were significantly older (49 years vs. 43 years; p < 0.001) and had more lymphovascular invasions (22% vs. 14%; p = 0.03) compared with FTC patients. Distant metastases were confirmed in 40 patients (8%) in the FTC group and in two patients (3%) in the HCC group (p = 0.07). Distant metastases were significantly associated with older age, widely invasive cancer and extrathyroidal invasion. Only 14 patients (3%) had recurrent disease and there was no significant difference between FTC and HCC groups (p = 0.38). Recurrence was associated with larger tumor size and cervical lymph node metastasis. CONCLUSIONS: HCC patients were older and had more lymphovascular invasions than FTC patients. However, FTC and HCC patients had similar initial clinicopathological features. Older age, wide invasiveness and extrathyroidal invasion were independent risk factors for predicting distant metastases in FTC and HCC patients.
Adenocarcinoma, Follicular/*epidemiology/secondary/surgery
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Adult
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Age Factors
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*Diet
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Female
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Humans
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*Iodine
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Lymphatic Metastasis
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Male
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Middle Aged
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Neoplasm Recurrence, Local
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*Nutritional Status
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Republic of Korea/epidemiology
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Retrospective Studies
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Risk Factors
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Tertiary Care Centers
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Thyroid Neoplasms/*epidemiology/pathology/surgery
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Thyroidectomy
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Time Factors
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Treatment Outcome