Introduction: Smoking is a risk factor for development of psoriasis. The severity of psoriasis has also been associated with smoking. Smoking may be an important modifiable factor in psoriasis treatment. Reduction or cessation of smoking in psoriasis patients is relevant as psoriasis is also associated with cardiovascular disease. Objectives: This study aims to determine the association between smoking and severity of psoriasis, and to investigate the frequency of concomitant cardiovascular risk factors in our psoriasis patients. Method: A 6-month prospective, controlled study. Consecutive patients with chronic plaque psoriasis attending Dermatology Clinic, Kuala Lumpur Hospital were screened. Smokers were identified, age, gender and ethnic matched non-smokers were recruited. Patients were evaluated for Psoriasis Severity Index (PASI) and body surface area (BSA) affected by psoriasis. Results: A total of 89 chronic plaque psoriasis patients were screened. Twenty four smokers and 24 matched non-smokers were included in the study. There were no significant differences in the presence of medical co-morbidities, blood pressure, body mass index (BMI), age of psoriasis onset and duration of disease in both groups. The mean age patients started smoking was 20.2±5.6 years, the mean duration of smoking was 16.3±11.1 years, the number of cigarette per day 11.9±6.1 sticks and the number of cigarette pack years was 10.7±9.2. BSA affected by psoriasis and PASI score were significantly higher in the subjects who smoked compared to the non smokers. Conclusion: Smoking is associated with more severe psoriasis in terms of BSA and PASI. Cardiovascular risk factors are common in psoriasis patients. These patients (smokers and non-smokers) require interventions to reduce their cardiovascular risks.

Background: Dermatology in the Malaysian undergraduate medical curriculum is included as a subspecialty subject in Internal Medicine. The dermatology course content for undergraduate varies among the different teaching institutions. A standardized curriculum is required to prepare graduates for clinical dermatological practices in a tropical country and also applicable worldwide. Methods: The Delphi method is used to reach a consensus on the curriculum’s core content. A questionnaire with lists of dermatological conditions was developed by a panel of dermatologists and family physician. A total of 60 participants comprising of 20 dermatologists, 20 family physicians and 20 general practitioners are asked to rate the importance of each dermatological conditions stated in the questionnaire. The same participants then answers the questionnaire again with results of the first round made available to them. The final curriculum content will be identified based on the panel’s collective opinions. Results: We present the results of the first part of the study which is the (questionnaire development). Section 1 of the questionnaire lists 20 topics according to the classification of dermatological diseases and common dermatological diseases. Section 2 expands each classification by listing specific diseases or conditions. There are 4 to 13 diseases identified under each classification. This provides a total of 171 options to be graded by each participant. Section 1 aimed to identify important topics based on the classification and common dermatological diseases. The list of specific diseases aimed to identify the important dermatological conditions or diseases under each classification. Conclusion: A standardized appropriate curriculum in dermatology is required for the Malaysian undergraduate teaching curriculum which is acceptable both locally and internationally. The finding of the study may be used to recommend a standard Malaysian medical undergraduate dermatology curriculum.

Elephantiasis nostras verrucosa occurs due to chronic lymphedema, characterized by cutaneous changes consisting of papillomatous, verrucous, and hyperkerototic lesions. Treatment of elephantiasis nostras verrucosa is challenging and results are often disappointing. We report our experience with a patient who was successfully treated with oral acitretin.

Prurigo pigmentosa is an inflammatory dermatosis characterized by a pruritic, symmetrically distributed erythematous papular or papulo-vesicular eruption on the trunk arranged in a reticulated pattern that resolves with hyperpigmentation. It is typically non-responsive to topical or systemic steroid therapy. The exact etiology is unknown, but it is more commonly described in the Far East countries. Dietary change is one of the predisposing factors. We report on nine young adult patients with prurigo pigmentosa, among whom five were on ketogenic diets prior to the onset of the eruptions. All cases resolved with oral doxycycline with no recurrence. We hope to improve the awareness of this uncommon skin condition among general practitioners and physicians so that disfiguring hyperpigmentation due to delayed diagnosis and treatment can be avoided.

Aged, 80 and over ; Chronic Disease ; Eczema ; diagnosis ; Humans ; Kaposi Varicelliform Eruption ; diagnosis ; Male

Background: Dermatology is a minor module in internal medicine undergraduate curriculum. Limited time is allocated for its teaching. Most graduates are inadequately prepared to diagnose and manage skin diseases. We aimed to identify the core content of a more effective dermatology module. Methods: A modified Delphi method was used to reach a consensus. A questionnaire was developed by a selected panel and sent to 20 dermatologists, family physicians and general practitioners (GPs), respectively. They were asked to rate diseases according to importance. The participants then answered the questionnaire again with results of the first round made available to them. The final module content was identified based on the panel’s collective opinions. Results: Eleven topics had mode and median values of 1 with an agreement level of more than 70%. They were as follows: (1) skin structure and function; (2) infections and infestations; (3) the skin in systemic diseases; (4) dermatology emergencies; (5) drug eruptions; (6) psoriasis; (7) eczema; (8) sexually transmitted infections; (9) leprosy; (10) acne; and (11) clinical skills and diagnostic procedures. A total of 56 diseases were identified as important. Conclusion: Results of this study reflect the importance of understanding the influence of regional factors on common and important skin diseases. These topics may be used to develop a more effective dermatology module for the Malaysian undergraduate medical curriculum.

Introduction: Psoriasis is considered an independent cardiovascular risk factor. This study aims to determine and describe the cardiac abnormalities using echocardiography and electrocardiography in patients with plaque psoriasis. Methods: This is a case control study of psoriasis patients with no previous history of cardiac disease. One hundred and thirty-five patients attending the Dermatology Clinic, Hospital Kuala Lumpur were recruited over one year. A full history, physical examination, echocardiogram and electrocardiogram were done. The controls were 135 age and sex matched healthy individuals. Results: The psoriasis group had a significantly higher body mass index and blood pressure. The echocardiogram showed that the mean left ventricular wall diastolic thickness, aortic annulus diameter and isovolumetric relaxation time of the left ventricle was significantly prolonged, and a higher prevalence of tricuspid regurgitation in psoriasis. On the electrocardiogram, more psoriasis patients had left ventricular hypertrophy, ischaemia and right bundle branch block. The QRS interval was significantly shorter in these patients. The tricuspid valve E/A ratio was significantly lower in patients with psoriatic arthropathy. The mitral valve early filling velocity deceleration time, tricuspid valve E/A ratio and QRS interval were significantly higher among systemic therapy naïve patients. The mean mitral and tricuspid valve E/A ratio were significantly lower; and the mean ascending aorta diameter larger, in those with psoriasis for more than ten years. Conclusion: Psoriasis may be associated with an increased risk of cardiac abnormalities suggesting diastolic dysfunction and tricuspid regurgitation. These abnormalities appear to be related to disease duration. Further studies employing newer echocardiographic and cardiac imaging techniques are needed to validate this.

Doctor shopping increases health economic burden and morbidities. Its prevalence and predisposing factors have to beidentified in order to formulate preventive measures. We aimed to determine the prevalence of doctor shopping, its reasonsand predisposing factors by conducting a cross sectional study of new patients at the Dermatology Clinic, UniversitiKebangsaan Malaysia Medical Centre (UKMMC). Doctor shopping was defined as having consultation with ≥3 healthcareproviders without a referral for the same illness prior to the patients’ visit to UKMMC. Reasons and contributing factorswere classified as disease, healthcare provider, logistic and cost related. Data was collected by a face to face interview.Dermatology Life Quality Index (DLQI) questionnaire determined disease impact on the patients. A total of 58 (55.8%)female and 46 (44.2%) male patients participated. Referral was patient-initiated in 51.9% while 40.4% were doctorshopping. Age, gender, ethnicity, income, occupation and type of health finance provider were not associated with thisbehaviour. About 95% doctor shopped due to disease factors: searching for a cure (95.2%), lack of improvement (88.1%),worsening disease (50.0%), dissatisfaction with treatment (31.0%), seeking other opinions (26.2%) and exploringtreatment options (26.2%). Impaired DLQI (OR 1.17; 95% CI 1.08,1.38), p 0.04, and disease related factors (OR 6.57; 95%CI 1.52, 7.72), p 0.041 were significant independent risk factors. Doctor shopping is very common among our patients.Reasons and predisposing factors are predominantly disease related. Patient education and counselling is important inmanagement of dermatological diseases to prevent doctor shopping.

Antihistamine is standard chronic spontaneous urticaria (CSU) therapy. Weight gain is a side effect of concern as prolonged high dose therapy is common. We investigated the effects of 12-weeks loratadine therapy on weight, appetite and parameters of metabolic syndrome (MetS). A cohort study was performed involving CSU patients aged ≥18 years. Patients with diseases or on drugs affecting weight or appetite were excluded. CSU was treated according to standard management. Weight, height, waist circumference (WC), body mass index (BMI) and blood pressure (BP), Urticaria Activity Score 7 (UAS7), Dermatology Life Quality Index (DLQI), hunger and satiety questionnaire, fasting blood sugar (FBS) and fasting lipid profile (FLP) were obtained at baseline, week 6 and week 12. Loratadine cumulative dose were determined. Thirteen (33.33 %) males and 26 (66.67 %) females aged 33.00 (12.00) years participated. Median weight was 62.55 (18.30) kg, BMI 24.60 (6.80) kg/m2, 13(33.33%) patients had normal weight, 12 (30.77%) overweight, 11 (28.21%) obese and 3 (7.69%) underweight. Significant weight gain was observed at week 6, 67.56 ± 16.14 kg vs 68.16 ± 16.95 kg, p < 0.05 and 67.56 ± 16.14 kg vs 64.73 ± 14.60 kg, p = 0.04 at week 12. Changes in BMI, WC, BP, FBS and FLP were insignificant. Three patients developed MetS. Hunger and satiety scores were unaffected. Loratadine induced weight gain despite no effects on appetite. Weight should be monitored in patients on long term loratadine therapy.

This article provides information on allergy testing and serves as a simple guide for physicians who are considering using allergy testing as a step in patient management. Basic principles of allergy testing, indications for testing, and how and when to choose a suitable allergy test are discussed. Allergy testing in general refers to evaluation of either type I or type IV hypersensitivity reactions. The type I (immediate) reaction is evaluated using the skin prick test (in vivo) or serum IgE (in vitro) test methods, while the type IV (delayed) reaction is determined via the skin patch test method. The allergens responsible for a specific reaction can be identified from allergy testing, and this information is useful in administering avoidance measures. Appropriate treatment of allergic reactions along with allergen avoidance ensure a successful treatment outcome and prevent future reactions.