1. Potential predictors for mental stress-induced myocardial ischemia in patients with coronary artery disease
Mei-Yan LIU ; Ya YANG ; Li-Jun ZHANG ; Li-Hong PU ; Dong-Fang HE ; Jian-Yang LIU ; Adam HAFEEZ ; Yu-Chuan DING ; Huan MA ; Qing-Shan GENG
Chinese Medical Journal 2019;132(12):1390-1399
Background:
Mental stress-induced myocardial ischemia (MSIMI) is closely associated with adverse cardiac events in patients with coronary artery disease (CAD) and we aimed to determine whether biomarkers and blood pressure could be potential predictors of MSIMI.
Methods:
This study enrolled 82 patients with documented CAD between June 1, 2017 and November 9, 2017. Patient blood samples were obtained at resting period and at the end of mental arithmetic. Then, patients were assigned to MSIMI positive group and MSIMI negative group. The main statistical methods included linear regression, receiver operating characteristic (ROC) curves, and logistic regression.
Results:
Patients with CAD with MSIMI had significantly greater median resting N-terminal pro-brain natriuretic peptide (NT-proBNP, 141.02 [45.85–202.76] pg/mL