No abstract available.
Acute Generalized Exanthematous Pustulosis* ; Parvovirus*

No abstract available.
Acute Generalized Exanthematous Pustulosis* ; Early Diagnosis*

No abstract available.
Acute Generalized Exanthematous Pustulosis* ; Early Diagnosis*

Acute generalized exanthematous pustulosis (AGEP) is clinically characterized by the abrupt onset of erythema, non-follicular superficial pustules, fever and rapid spontaneous healing. Other findings such as peripheral neutrophilia and histologically neutrophilic spongiosis and microabscess also suggest AGEP. Its cause was focused on drug and viral infection, but the latter lacks objective evidence as a causative factor. We report two cases of AGEP that serially occurred in siblings without obvious drug history, which strongly suggests there is a possibility that AGEP could be caused by viral infection.
Acute Generalized Exanthematous Pustulosis* ; Erythema ; Fever ; Humans ; Neutrophils ; Siblings*

Acute generalized exanthematous pustulosis(AGEP) is characterized by the abrupt onset of widespread pustules on an erythematous base and rapid spontaneous healing. Most cases appear to be related to drug reactions, mainly antibiotics, viral infections, and hypersensitivity to mercury. We report two cases of acute generalized exanthematous pustulosis which presented with widespread tiny pustules on the whole body. Histopathologic examinations of both cases showed subcorneal neutrophilic pustules with perivascular polymorphous cellular infiltration. We suspected that the possible cause of two cases was inhalant mercury and carbamazepine.
Acute Generalized Exanthematous Pustulosis* ; Anti-Bacterial Agents ; Carbamazepine ; Hypersensitivity ; Neutrophils

Acute generalized exanthematous pustulosis (AGEP) is a cutaneous reaction principally induced by drugs. Spontaneous resolution is observed in most patients. However, severe cases required systemic corticosteroid administration. Hydroxychloroquine, which is used to treat some dermatologic and rheumatologic diseases because of its anti-inflammatory and immunosuppressive effects, is an uncommon cause of AGEP. A 67-year-old female patient presented with severe AGEP due to hydroxychloroquine treatment. She was recalcitrant to supportive care and systemic corticosteroid treatment butwas successfully treated with cyclosporine. Hydroxychloroquine-induced AGEP occurs in women with underlying rheumatologic diseases, has a longer latent period, and has a severe course usually requiring systemic treatment.
Acute Generalized Exanthematous Pustulosis* ; Aged ; Cyclosporine* ; Female ; Humans ; Hydroxychloroquine

Acute generalized exanthematous pustulosis(AGEP) presents with the abrupt onset of a wide spread pustules on an erythematous base and rapid spontaneous healing. The most possible causes of AGEP seem to be antibiotics, viral infection and exposure to mercury. We report five cases of acute generalized exanthematous pustulosis, all of which presented wide spreaded tiny pustules on an erythematous base. Histopathologic examination showed that there are subcorneal pustules, rete ridge elongations and perivascular infiltration. We suspected that the possible causes of five cases were pharyngitis and various drugs each.
Acute Generalized Exanthematous Pustulosis* ; Anti-Bacterial Agents ; Pharyngitis

No abstract available.
Acute Generalized Exanthematous Pustulosis* ; Chickens* ; Eating* ; Hemodynamics* ; Lacquer*

Acute generalized exanthematous pustulosis is a skin reaction characterized by an acute onset, fever, and a cutaneous eruption with non-follicular sterile pustules on edematous erythema. It mimics many of the features of pustular psoriasis but is differentiated by its characteristic clinical course and history. The cause is usually ingested drugs. We report a case of acute generalized exanthematous pustulosis possibly induced by ritodrine
Acute Generalized Exanthematous Pustulosis ; Erythema ; Fever ; Psoriasis ; Ritodrine ; Skin

Acute generalized exanthematous pustulosis (AGEP) is characterized by acute nonfollicular sterile pustules on a background of edematous erythema. Hydroxychloroquine (HCQ), an antimalarial drug, widely used to treat rheumatic and dermatologic diseases. HCQ has been reported to be an uncommon cause of AGEP. We report a 60-year-old woman with rheumatoid arthritis requiring the use of HCQ presented fever and erythematous eruption on the trunk with sterile pustules. Leukocytosis and elevated erythrocyte sedimention rate noted on laboratory examination. On the histopathological examination of the skin biopsy specimen showed neutrophilic infiltration and scattered eosinohpils. The lesions were resolved with removal of HCQ. The clinical course was consistent with the diagnosis of AGEP associated with HCQ. We reported a case of typical AGEP associated with HCQ in a patient with Rheumatoid arthritis. The patient presented resolution from cutaneous lesions with withdrawal of culprit drug, without the need of systemic steroid.
Acute Generalized Exanthematous Pustulosis ; Arthritis, Rheumatoid ; Biopsy ; Erythema ; Erythrocytes ; Female ; Fever ; Humans ; Hydroxychloroquine ; Leukocytosis ; Neutrophils ; Skin