1.Clinical review on surgical acute abdomen.
Journal of the Korean Surgical Society 1992;43(3):430-438
No abstract available.
Abdomen, Acute*
2.Evaluation of Acute Toxicity Induced by Supercritical Carbon Dioxide Extract of Canarium odontophyllum (CO) Miq. Pulp Oil in SPF Sprague Dawley Rats
Malaysian Journal of Medicine and Health Sciences 2019;15(SP1):113-119
Introduction: Different solvents extraction was used to extract the good fatty acid composition of Dabai fruits. Nevertheless, solvents extraction may exhibit harmful effects. The present study was aimed to evaluate the safety of using supercritical carbon dioxide extraction (SCO2) of dabai pulp oil by acute toxicity study in Specific Pathogen Free (SPF) Sprague-Dawley (SD) rats. Methods: The CO pulp oil extract was prepared by SCO2 extraction of the freezedried pulp and was administered orally to SPF SD rats (consisted of 5 rats/sex/group) at upper limit dose 5000 mg/kg body weight (BW) for 14 days. The study includes the control and treatment groups, each consisting of 5 male and female rats. The rats were fed and allowed to drink sterilized water ad libitum. Fatty acid composition (FAC) of the extract was determined using GC-FID. Electrolytes and biochemical parameters in blood, as well as relative organs weight were measured. Results: The extract at a single dose of 5000 mg/kg did not cause any acute toxicity effects or mortality to the treatment of rats during observation periods in 14 days. FAC of the SCO2 extracted oil exhibited high content of palmitic and linoleic acids. The relative organs weights (ROW) and histopathology of rats were within normal range. Conclusion: Thus, the LD50 was estimated to be more than 5000 mg/kg of CO pulp oil extract and can be considered for further investigation for its therapeutic efficacy in a larger animal model
Acute toxicity
3.Acute Toxicity Study of Intravenous Administration of Thymoquinone-Loaded Nanostructured Lipid Carrier (TQ-NLC) in Sprague Dawley Rats
Malaysian Journal of Medicine and Health Sciences 2019;15(SP2):51-57
Introduction: Thymoquinone (TQ), a bioactive compound from Nigella sativa is known for its various medicinal properties. Due to the low solubility of TQ, nanostructured lipid carrier (NLC) has been used as a delivery system to improve its efficacy. Nevertheless, the effect of TQ-NLC when administered intravenously is unclear. This study investigated the acute toxicity profile of intravenous administration of TQ-NLC in an in vivo model. Methods: Twelve female Sprague dawley rats were assigned randomly into two groups (n=6); a control and a treatment group that received normal saline and 25 mg/kg TQ-NLC, respectively, via intravenous injection. The rats were observed for 14 days for any alterations to their usual physical conditions such as behaviour and mortality, body weight, food intake, organ-to-body weight ratio, and haematological, biochemical and histopathological profile. Results: There were no significant changes (p>0.05) in the body weight, food intake, organ-to-body weight ratio, and haematological, biochemical and histopathological profile between TQ-NLC treatment and the control group. However, inflammation was observed at the site of injection on the rat’s tail. Conclusion: Intravenous administration of TQ-NLC (25 mg/kg) did not exert acute toxic effect in female Sprague dawley rats. The data can be used as a basis to further develop TQNLC as a potential therapeutic drug.
Acute toxicity
4.A case of acute eosinophilic leukemia and trisomy 8.
Jung OH ; Kyung Ja HAN ; SangIn SHIM ; Sun Moo KIM ; Jong Wook LEE ; Dong Jip KIM
Korean Journal of Clinical Pathology 1991;11(1):83-87
No abstract available.
Leukemia, Eosinophilic, Acute*
;
Trisomy*
5.NUP98 Rearrangement in Acute Myelomonocytic Leukemia With t(11;19)(p15;p12): The First Case Report Worldwide.
Hyeon Ho LIM ; Gyu Dae AN ; Kwang Sook WOO ; Kyeong Hee KIM ; Jeong Man KIM ; Sung Hyun KIM ; Jin Yeong HAN
Annals of Laboratory Medicine 2017;37(3):285-287
No abstract available.
Leukemia, Myelomonocytic, Acute*
6.Acute Renal Failure.
Korean Journal of Pediatrics 2004;47(Suppl 4):S912-S918
No abstract available.
Acute Kidney Injury*
7.An observation on postoperative acute renal failure.
Journal of the Korean Surgical Society 1992;42(3):367-375
No abstract available.
Acute Kidney Injury*
8.Urinary Diagnostic Indices in Acute Kidney Injury.
Korean Journal of Nephrology 2009;28(3):169-172
No abstract available.
Acute Kidney Injury
9.Severe Acute Respiratory Syndrome, SARS.
Journal of the Korean Academy of Family Medicine 2003;24(6):516-523
No abstract available.
Severe Acute Respiratory Syndrome*
10.Risk-adopted therapy for acute myelogenous leukemia.
Korean Journal of Medicine 2005;69(2):126-134
No abstract available.
Leukemia, Myeloid, Acute*