No abstract available.
Actins ; Keratosis, Actinic ; Prevalence

No abstract available.
Actins* ; Capillaries* ; Granuloma* ; Humans ; Skin*

No abstract available.
Actins* ; Humans ; Keratosis, Actinic* ; Phototherapy*

Actinic granuloma (O'Brien) is an annular inflammatory reaction that develops in skin after long-term sun-exposure. Anetoderma is characterized by discrete skin lesions that appear to be loose and wrinkled. The primary type arises in clinically normal skin, and the secondary type appears in lesions of other disorders. We describe a case of anetoderma that developed on the neck, both arms and calves, and showed histopathological findings of actinic granuloma.
Actins* ; Anetoderma* ; Arm ; Granuloma ; Neck ; Skin

Lichenoid keratosis (LK), a lichen planus-like keratosis, is a rather frequent skin disorder that has some histological features similar to lichen planus. However, the classification system for LK has not been settled. We report two cases of LK and propose a new classification for LK correlating with clinicohistopathological findings.
Actins* ; Classification ; Keratosis* ; Lichen Planus ; Lichens ; Skin

Lichen planus pigmentosus (LPP) is an uncommon variant of lichen planus that presents clinically as hyperpigmented, dark brown macules or patches in sun-exposed areas and flexural folds. LPP has been described previously as a pigmented form of actinic lichen planus or as erythema dyschromicum perstans. Recently, however, these diseases have been recognized as different clinical entities. Histopathologically, in atrophic epidermis, vacuolar alteration of the basal cell layer and scarce lymphohistiocytic lichenoid infiltration and pigment incontinence are seen. Herein, we report a case of LPP that developed in a unilateral linear pattern, probably in relation to Blaschko's lines.
Actins ; Epidermis ; Erythema ; Lichen Planus ; Lichens

Wolf's isotopic response describes the occurrence of a new, unrelated disease that appears at the location of a previously healed disease, most commonly herpes zoster. Several cutaneous reactions including granuloma annulare have been known to occur within resolved herpes zoster lesions. We report a case of actinic granuloma which developed on a site previously affected by herpes zoster, and is thought to be an isotopic response.
Actins* ; Cicatrix* ; Granuloma Annulare ; Granuloma* ; Herpes Zoster*

There have been several reports of more than one type of porokeratosis occurring in the same family or the same individual. We hope to support the view of different phenotypic expressions of a common genetic aberration by describing an additional case of porokeratosis of Mibelli on the perianal area and DSAP on the face, forearms occurring in a 45-year-old man.
Actins* ; Forearm ; Hope ; Humans ; Middle Aged ; Porokeratosis*

Coactosin-like protein 1 (Cotl1), a member of the actin-depolymerizing factor (ADF)/cofilin family, was first purified from a soluble fraction of Dictyostelium discoideum cells. Neuronal migration requires cytoskeletal remodeling and actin regulation. Although Cotl1 strongly binds to F-actin, the role of Cotl1 in neuronal migration remains undescribed. In this study, we revealed that Cotl1 overexpression impaired migration of both early- and late-born neurons during mouse corticogenesis. Moreover, Cotl1 overexpression delayed, rather than blocked, neuronal migration in late-born neurons. Cotl1 expression disturbed the morphology of migrating neurons, lengthening the leading processes. This study is the first to investigate the function of Cotl1, and the results indicate that Cotl1 is involved in the regulation of neuronal migration and morphogenesis.
Actins ; Animals ; Dictyostelium ; Humans ; Mice ; Morphogenesis ; Neurons

Although there are many methods for the treatment of actinic cheilitis including cryotherapy, vermilionectomy, and topical fluorouracil, the choice of treatment should be determined after assessment of the lesion and its location. A 67-year old woman developed actinic chelitis, where a thick keratotic plaque occupied a half of her lower lip. Surgical removal of the lesion was difficult because of its size, and repeated cryotherapy treatment also failed. The lesion was then successfully treated by a the topical application of combined fluorouracil and salicylic acid solution.
Actins* ; Aged ; Cheilitis* ; Cryotherapy ; Female ; Fluorouracil ; Humans ; Lip ; Salicylic Acid