1.The Ability of beta-Cells to Compensate for Insulin Resistance is Restored with a Reduction in Excess Growth Hormone in Korean Acromegalic Patients.
Soo Kyoung KIM ; Sunghwan SUH ; Ji In LEE ; Kyu Yeon HUR ; Jae Hoon CHUNG ; Moon Kyu LEE ; Yong Ki MIN ; Jae Hyeon KIM ; Jong Hyun KIM ; Kwang Won KIM
Journal of Korean Medical Science 2012;27(2):177-183
The aim of this study was to assess the prevalence of diabetes and to study the effects of excess growth hormone (GH) on insulin sensitivity and beta-cell function in Korean acromegalic patients. One hundred and eighty-four acromegalic patients were analyzed to assess the prevalence of diabetes, and 52 naive acromegalic patients were enrolled in order to analyze insulin sensitivity and insulin secretion. Patients underwent a 75 g oral glucose tolerance test with measurements of GH, glucose, insulin, and C-peptide levels. The insulin sensitivity index and beta-cell function index were calculated and compared according to glucose status. Changes in the insulin sensitivity index and beta-cell function index were evaluated one to two months after surgery. Of the 184 patients, 17.4% were in the normal glucose tolerance (NGT) group, 45.1% were in the pre-diabetic group and 37.5% were in the diabetic group. The insulin sensitivity index (ISI0,120) was significantly higher and the HOMA-IR was lower in the NGT compared to the diabetic group (P = 0.001 and P = 0.037, respectively). The ISI0,120 and disposition index were significantly improved after tumor resection. Our findings suggest that both insulin sensitivity and beta-cell function are improved by tumor resection in acromegalic patients.
Acromegaly/*diagnosis/etiology/metabolism
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Adult
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Asian Continental Ancestry Group
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Blood Glucose/analysis
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C-Peptide/analysis
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Diabetes Mellitus/epidemiology
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Female
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Glucose Tolerance Test
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Human Growth Hormone/secretion
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Humans
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Insulin/blood/secretion
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*Insulin Resistance
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Insulin-Secreting Cells/cytology/*physiology
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Male
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Middle Aged
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Prediabetic State/epidemiology
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Republic of Korea