Low level laser or light treatment on the various clinical condition is getting considerable attention now. However, there has been no report about the clinical effect of low level polarized polychromatic noncoherent light (LPPL) on the inflammatory skin disease. We experienced a case of acrodermatitis continua in a pregnant woman refractory to any conventional treatment including the most potent topical steroid. She was successfully treated with LPPL. LPPL could be a possible treatment modality producing substantial clinical result in inflammatory skin condition without any side-effect.
Acrodermatitis/*therapy ; Adult ; Calcitriol/analogs & derivatives/therapeutic use ; Female ; Humans ; Inflammation/therapy ; Light ; Phototherapy/*methods ; Pregnancy ; Pregnancy Complications ; Psoriasis/drug therapy ; Skin Diseases/*therapy

Maple syrup urine disease(MSUD) is an autosomal recessive disorder involving the metabolism of the branched-chain amino acids(BCAA) such as leucine, isoleucine and valine. The disorder is due to a defect in branched-chain alpha-ketoacid dehydrogenase(BCKAD) and the classic form causes rapid progressive and overwhelming illness beginning in the first weeks of life, present with poor feeding, lethargy, change in muscle tone, acidosis, seizures and coma. The goal of therapy in acutely ill patients with MSUD is an immediate reduction in the plasma levels of the BCAAs and branched-chain ketoacids. In this report, we describe an infant with MSUD who was treated by dietary therapy alone. During the therapy, acrodermatitis enteropathica-like syndrome developed with low plasma isoleucine concentration while she was receiving a formula deficient in BCAAs.
Acer* ; Acidosis ; Acrodermatitis* ; Amino Acids, Branched-Chain ; Coma ; Diet Therapy* ; Diet* ; Humans ; Infant ; Isoleucine ; Lethargy ; Leucine ; Maple Syrup Urine Disease* ; Metabolism ; Plasma ; Seizures ; Valine

Liver infarction and acrodermatitis enteropathica are rare complications of chronic pancreatitis. This report shows the case of a 56-year-old man who developed liver infarction due to portal vein thrombosis from chronic pancreatitis and acrodermatitis enteropathica during the course of his treatment. The rare combination of these complications in a patient with chronic pancreatitis has never previously been reported in the literature.
Acrodermatitis/*etiology/pathology/therapy ; Chronic Disease ; Human ; Infarction/*etiology ; Liver/*blood supply ; Male ; Middle Aged ; Pancreatitis/*complications ; Portal Vein ; Venous Thrombosis/complications/etiology ; Zinc/administration & dosage/deficiency

BACKGROUND: Zinc is an essential trace and has a close relation with skin metabolism and zinc deficiency is associated with acrodermatitis enteropathica, inflammatory bowel disease, chemotherapy, intravenous hyperalimentation, chronic diarrhea and other malabsoption state. OBJECTIVE: The purpose of this study was to analyze the clinical characteristics of zinc deficiency presented as a skin manifestation of acrodermatitis enteropathica. METHODS: In a retrospective study including 45 patients, we reviewed the clinical features of zinc deficiency presented as a skin manifestation of acrodermatitis enteropathica. RESULTS: The ratio of male-to-female patients was 1.14:1 and the onset of the disease occured in childhood in 14 cases, and adulthood in 31 cases. The associated diseases were bowel diseases(13 cases), chemotherapy(11 cases), and postgastrectomy state(5 cases), only acrodermatitis enteropathica without associated disease(4 cases), and the other associated diseases were anorexia nervosa, malnutrition in old age, chronic pancreatitis and alcoholic liver disease, etc. The most common skin manifestation was erythematous scaly patches with erosion(77.8%) and vesicles, bullae, pustules and acneiform eruptions also developed. The perianal area was the most common anatomic site and the skin lesions were associated with diarrhea(35.6%), candida infection(20.0%), and severe hair loss(2.2%). In laboratory findings, low serum zinc levels were present in 26 patients among the 36 patients and a lower limit of the normal range of serum zinc was present in 8 patients among the 10 patients with normal zinc levels. Decreased serum albumin and protein level(48.9%), anemia (26.7%), and decreased alkaline phosphatase(6.7%) were observed. CONCLUSION: We should pay special attention to the prevention of zinc deficiency in bowel disease, chemotherapy, chronic diarrhea and other malabsoption state. To prevent zinc deficiency, detailed skin examination was necessary and zinc should be added to maintenance therapy during chronic malnutrition and malabsorption state.
Acneiform Eruptions ; Acrodermatitis* ; Anemia ; Anorexia Nervosa ; Candida ; Diarrhea ; Drug Therapy ; Hair ; Humans ; Inflammatory Bowel Diseases ; Liver Diseases, Alcoholic ; Malnutrition ; Metabolism ; Pancreatitis, Chronic ; Parenteral Nutrition, Total ; Reference Values ; Retrospective Studies ; Serum Albumin ; Skin Manifestations* ; Skin* ; Zinc*