1.The Usefulness of Bone Scintigraphy in SAPHO Syndrome.
Korean Journal of Nuclear Medicine 2002;36(4):255-260
No abstract available.
Acquired Hyperostosis Syndrome*
;
Radionuclide Imaging*
3.A Case of SAPHO Syndrome.
Hye Jeong CHOI ; Jae Wook MYUNG ; Jun Ki MIN ; Mi Sook SUNG ; Chul Jong PARK
Korean Journal of Dermatology 2004;42(2):208-210
The term, SAPHO (synovitis, acne, pustulosis, hyperostosis, and osteitis) syndrome is an acronym to designate a clinico-radiologic entity with combination of skin, bone, and joint manifestations. We, herein, present a case of SAPHO syndrome in a 27-year-old man with pruritic, localized, crops of deep-seated pustules on both palms and soles for 2 years, and multiple joints pain including anterior upper chest pain for 3 years. Histopathologically, the palm showed a large intraepidermal cavity filled with many neutrophils, and many typical spongiform pustules at the wall of it. Radiographically, the left sternoclavicular joint showed synovitis, osteitis and hyperostosis.
Acne Vulgaris
;
Acquired Hyperostosis Syndrome*
;
Adult
;
Chest Pain
;
Humans
;
Hyperostosis
;
Joints
;
Neutrophils
;
Osteitis
;
Skin
;
Sternoclavicular Joint
;
Synovitis
4.Two cases of SAPHO syndrome.
Jee Hyun PARK ; Ho Seok SUH ; Kwang Won SEO ; In Du JEONG ; Hyun Chul JUNG ; Jong Soo LEE ; Seung Won CHOI
Korean Journal of Medicine 2003;65(Suppl 3):S782-S787
We describe two cases of SAPHO syndrome with history of palmoplantar pustulosis and pain on the anterior chest wall and lower back area. The acronym SAPHO (synovitis, acne, pustulosis, hyperostosis and osteitis) syndrome includes a group of disorders characterized by bony lesions commonly involving the anterior chest wall and associated with skin manifestations. The skeletal manifestation is characterized by the association of inflammation and hyperostotic change, in the form of sternocostoclavicular hyperostosis, spondyloarthropathy and chronic recurrent multifocal osteomyelitis. Common cutaneous lesions include palmoplantar pustulosis, pustulotic psoriasis, and severe forms of acne. The pathogenesis remains elusive, but a link with seronegative spondyloarthropathy is probable. To date, the treatment is empirical. Nonsteroidal anti-inflammatory drugs are the first choice, and other drugs including corticosteroid, disease modifying antirheumatic drugs, pamidronate, and infliximab have been tried with some therapeutic benefit. SAPHO syndrome is a condition in the differential diagnosis of infectious or tumorous conditions of the bone. Early and proper diagnosis is important to avoid unnecessary investigations or treatments.
Acne Vulgaris
;
Acquired Hyperostosis Syndrome*
;
Antirheumatic Agents
;
Diagnosis
;
Diagnosis, Differential
;
Hyperostosis
;
Hyperostosis, Sternocostoclavicular
;
Inflammation
;
Osteomyelitis
;
Psoriasis
;
Skin Manifestations
;
Spine
;
Spondylarthropathies
;
Thoracic Wall
;
Infliximab
5.Two cases of SAPHO syndrome.
Jee Hyun PARK ; Ho Seok SUH ; Kwang Won SEO ; In Du JEONG ; Hyun Chul JUNG ; Jong Soo LEE ; Seung Won CHOI
Korean Journal of Medicine 2003;65(Suppl 3):S782-S787
We describe two cases of SAPHO syndrome with history of palmoplantar pustulosis and pain on the anterior chest wall and lower back area. The acronym SAPHO (synovitis, acne, pustulosis, hyperostosis and osteitis) syndrome includes a group of disorders characterized by bony lesions commonly involving the anterior chest wall and associated with skin manifestations. The skeletal manifestation is characterized by the association of inflammation and hyperostotic change, in the form of sternocostoclavicular hyperostosis, spondyloarthropathy and chronic recurrent multifocal osteomyelitis. Common cutaneous lesions include palmoplantar pustulosis, pustulotic psoriasis, and severe forms of acne. The pathogenesis remains elusive, but a link with seronegative spondyloarthropathy is probable. To date, the treatment is empirical. Nonsteroidal anti-inflammatory drugs are the first choice, and other drugs including corticosteroid, disease modifying antirheumatic drugs, pamidronate, and infliximab have been tried with some therapeutic benefit. SAPHO syndrome is a condition in the differential diagnosis of infectious or tumorous conditions of the bone. Early and proper diagnosis is important to avoid unnecessary investigations or treatments.
Acne Vulgaris
;
Acquired Hyperostosis Syndrome*
;
Antirheumatic Agents
;
Diagnosis
;
Diagnosis, Differential
;
Hyperostosis
;
Hyperostosis, Sternocostoclavicular
;
Inflammation
;
Osteomyelitis
;
Psoriasis
;
Skin Manifestations
;
Spine
;
Spondylarthropathies
;
Thoracic Wall
;
Infliximab
7.Two Cases of SAPHO Syndrome.
Hyung Ran YUN ; Sung Soo JUNG ; Hee Kwan KOH ; Tae Seok YOO ; Je Kyung LEE ; Kwan Pyo HONG ; Tae Hwan KIM ; Jae Bum JUN ; In Hong LEE ; Sang Cheol BAE ; Dae Hyun YOO ; Seong Yoon KIM
The Journal of the Korean Rheumatism Association 1997;4(2):162-167
SAPHO (synovitis, acne, pustulosis, hyperostosis, osteitis) syndrome designates a group of articular and osseous manifestations frequently combined with skin disorders. Its fundamental component is inflammatory, pseudoinfectious, and sterile osteitis. The anterior chest wall is the most frequent localization and all the components of this structure may be involved. Palmoplantar pustulosis, psoriasis, acne conglobata, acne ulcerans, acne fulminans, pyoderma gangrenosum can be associated with the characteristic bone lesions. We report two cases of SAPHO syndrome : A 40-year-old female presented with both buttock pain with hyperostosis, costochondritis, synovitis and pustulosis palmaris and a 23-year-old male presented with migrating polyarthritis with costochondritis, synovitis, acne, pustulosis.
Acne Vulgaris
;
Acquired Hyperostosis Syndrome*
;
Adult
;
Arthritis
;
Buttocks
;
Female
;
Humans
;
Hyperostosis
;
Male
;
Osteitis
;
Psoriasis
;
Pyoderma Gangrenosum
;
Skin
;
Synovitis
;
Thoracic Wall
;
Young Adult
8.A Case of Palmoplantar Pustulosis Present in the Daughter of a SAPHO Syndrome Patient.
Ji Young CHOI ; Jae Min KIM ; Ran SONG ; Yeon Ah LEE ; Sang Hoon LEE ; Hyung In YANG ; Seung Jae HONG
Journal of Rheumatic Diseases 2015;22(2):127-131
SAPHO syndrome is a rare inflammatory, pseudoinfectious disease. Initially it was an acronym for Syndrome Acne Pustulosis Hyperostosis Osteitis, and the meaning of S was later changed to synovitis. It occurs predominantly in children and adults and is not common over 60 years. The most common clinical presentation is osteoarticular involvement at the anterior chest wall and skin manifestations may be evident, but it could occur years earlier or develop later. We report on two cases of mother and daughter. A 51-year-old female was diagnosed with SAPHO syndrome with costochondritis and palmoplantar pustulosis. Five years later, her 31-year-old daughter presented with similar skin manifestations of the hand and foot.
Acne Vulgaris
;
Acquired Hyperostosis Syndrome*
;
Adult
;
Child
;
Female
;
Foot
;
Hand
;
Humans
;
Hyperostosis
;
Middle Aged
;
Mothers
;
Nuclear Family*
;
Osteitis
;
Psoriasis
;
Skin Manifestations
;
Synovitis
;
Thoracic Wall
9.A Case of SAPHO Syndrome in a Palmoplantar Pustulosis Patient.
Oh Eon KWON ; Hong Seok KIM ; Seung Joo SIM ; Ki Hoon SONG ; Ki Ho KIM
Korean Journal of Dermatology 2005;43(2):239-243
SAPHO syndrome is characterized by sternocostoclavicular osteoarthritis and hyperostosis in the anterior chest wall, and skin changes such as palmoplantar pustulosis and acne. Despite the higher frequency of psoriasis in this syndrome, its inclusion in the psoriatic arthropathy spectrum is not yet clearly established to date. According to a familial series of the SAPHO syndrome, both sacroiliac and sternoclavicular joints could be involved. We report a case of SAPHO Syndrome in a palmoplantar pustulosis patient who had on associated osteoarticular manifestation. A 47-year-old woman had been treated for palmoplantar pustulosis for 15 months. Pain and tenderness then developed abruptly on the chest and neck, and multiple erythematous papules and pustules broke our over the whole body. Laboratory tests were negative for serum RA factor and ANA, and positive for HLA-B27. An X-ray showed a hyperostosis, osteolytic and osteosclerotic lesions in the costo-sterno-clavicular junction. 99mTc isotope scan showed the typical "Bull's head sign" in the anterior chest wall due to increased uptake in the manubrium and both sternoclavicular joints.
Acne Vulgaris
;
Acquired Hyperostosis Syndrome*
;
Arthritis, Psoriatic
;
Female
;
Head
;
HLA-B27 Antigen
;
Humans
;
Hyperostosis
;
Manubrium
;
Middle Aged
;
Neck
;
Osteoarthritis
;
Psoriasis
;
Skin
;
Sternoclavicular Joint
;
Thoracic Wall
;
Thorax
10.A Case of Refractory SAPHO Syndrome Treated with Etanercept.
Ye Ji KIM ; Song I BAE ; Sung Jae CHOI ; Young Ho LEE ; Jong Dae JI ; Gwan Gyu SONG
Journal of Rheumatic Diseases 2012;19(1):51-54
SAPHO syndrome, which has different skin changes and osteoarticular inflammation, is an acronym that stands for synovitis, acne, pustulosis, hyperostosis, and osteitis. Treatment of SAPHO syndrome includes non-steroidal anti-inflammatory drugs (NSAIDs), anti-rheumatic drugs, such as colchicines, corticosteroids and bisphosphonates, and disease-modifying agents. However, the treatment of SAPHO syndrome is controversial because it is a new clinical entity with unclear etiopathogenesis and inadequate clinical studies. We report a case with refractory SAPHO syndrome, which was successfully treated with a tumor necrosis factor (TNF)-alpha blocker.
Acne Vulgaris
;
Acquired Hyperostosis Syndrome
;
Adrenal Cortex Hormones
;
Antirheumatic Agents
;
Diphosphonates
;
Hyperostosis
;
Immunoglobulin G
;
Inflammation
;
Osteitis
;
Receptors, Tumor Necrosis Factor
;
Skin
;
Synovitis
;
Tumor Necrosis Factor-alpha
;
Etanercept