1.Response: Balsamic Vinegar Improves High Fat-Induced Beta Cell Dysfunction via Beta Cell ABCA1 (Diabetes Metab J 2012;36:275-9).
Diabetes & Metabolism Journal 2012;36(5):390-390
No abstract available.
Acetic Acid
2.Letter: Balsamic Vinegar Improves High Fat-Induced Beta Cell Dysfunction via Beta Cell ABCA1 (Diabetes Metab J 2012;36:275-9).
Diabetes & Metabolism Journal 2012;36(5):388-389
No abstract available.
Acetic Acid
3.Brief synthetic method of (N-bis(2-acyloxyethyl)-amino)-acetic acid. Application in synthesis of camptothecin-clorambucil complex utilized in the treatment of cancer
Pharmaceutical Journal 2005;0(7):7-10
Study on synthesis of [bis(2-acyloxyethyl)-amino]-acetic acid derivatives vat by synthetic method at solid phase and applying this method to synthesize a compound between camptothecin and clorambucil. Result: camptothecin - clorambucil CPT-2CLR compound were synthesized successfully by camptothecin esterification reaction with 2 (acid[bis(2-acyloxyethyl)-amino]-acetic). The [bis(2-acyloxyethyl)-amino]-acetic acid was synthesized simply and conveniently only by three-step on solid phase from bromoacetic trityl resin, diethanolamin and clorambucil. Attained productivity started from resin was 88%. This method may be applied in the synthesis of similar prodrugs and/or twin drugs
Neoplasms
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Therapeutics
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Acetic Acid
4.A case of ultrasound-guided cyst aspiration and sclerotherapy for the management of intractable pelvic pseudocyst.
Ka Hyun NAM ; Kwang Hun LEE ; Young Han KIM ; San Hui LEE ; Hyo In YANG ; Ja Young KWON ; Yong Won PARK
Korean Journal of Obstetrics and Gynecology 2008;51(12):1539-1544
Patients who underwent laparotomy often experience recurrent pelvic pseudocysts and they may need to undergo another laparotomy. Nowadays, many less invasive techniques such as the use of ultrasound-guided aspiration of pelvic pseudocysts and sclerotherapy were developed and were replacing laparotomy. We report a case of intractable pelvic pseudocyst treated successfully with ultrasound-guided cyst aspiration and sclerotherapy using acetic acid with a brief review of literature.
Acetic Acid
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Humans
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Laparotomy
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Sclerotherapy
5.Microwave Assisted Extraction, Optimization using Central Composite Design, Quantitative Estimation of Arjunic Acid and Arjunolic Acid using HPTLC and Evaluation of Radical Scavenging Potential of Stem Bark of Terminalia arjuna.
Sarita KHATKAR ; Arun NANDA ; S H ANSARI
Natural Product Sciences 2017;23(2):75-83
The optimization and microwave assisted extraction of stem bark of Terminalia arjuna, quantitative estimation of the marker compounds arjunic acid and arjunolic acid using HPTLC and the evaluation of free radical scavenging activity has been performed in this study. The central composite design was used for optimization and the values of parameters for optimized batch of microwave assisted extraction were 1000W (Power), 3 minutes (Time) and 1/120 (Solid/solvent ratio). The solvent system to carry out the HPTLC was toluene: acetic acid: ethyl acetate (5: 5: 0.5) and quantitative estimation was done using standard equations obtained from the marker compounds. The in-vitro free radical scavenging activity was performed spectrophotometrically using ascorbic acid as standard. The value of estimated percentage yield of arjunic acid and arjunolic acid was 1.42% and 1.52% which upon experimentation was obtained as 1.38% and 1.51% respectively. The DPPH assay of the different batches of microwave assisted extraction and marker compounds taken suggested that the marker compounds arjunic acid and the arjunolic acid were responsible for the free radical scavenging activity as the batch having the maximum percentage yield of the marker compounds showed best free radical scavenging effect as compared to standard ascorbic acid. The IC₅₀ value of the optimized batch was found to be 24.72 while that of the standard ascorbic acid was 29.83. Hence, the yield of arjunic acid and arjunolic acid has direct correlation with the free radical scavenging activity of stem bark extract of Terminalia arjuna and have potential to serve as active lead compounds for free radical scavenging activity.
Acetic Acid
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Ascorbic Acid
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Microwaves*
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Terminalia*
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Toluene
7.Acetic Acid Versus Chlorine Tablet Solution as Disinfectant of Non-Critical Environmental Surfaces
Pediatric Infectious Disease Society of the Philippines Journal 2021;22(2):93-99
Objectives:
This study aims to determine the bactericidal activity of 4% acetic acid versus chlorine tablets against gram negative and gram-positive microorganisms based on percentage reduction of microorganisms in hospital surfaces and suggest that it may be an effective alternative disinfectant.
Methodology:
This was an experimental study where microbiological sampling of hospital surfaces was used to determine bacterial growth. The study was conducted from November to December 2020 at National Children’s Hospital, a 200 bed capacity tertiary government hospital catering to children 0 to less than 19 years old. Non-critical hospital surfaces such as beds, bed rails and bedside tables were swabbed before and after intervention cleaning with chlorine tablets or 4% acetic acid solution.
Result:
Pre-swabbing, hospital surfaces showed the presence of Bacillus sp., Klebsiella pneumoniae and Coagulase Negative Staphylococcus (CONS). Post-application of 4% acetic acid solution resulted to 100% reduction of Bacillus sp., 70.8% reduction of CONS, and 19.5% reduction of Klebsiella pneumoniae while post-application of chlorine tablet solution showed 100% reduction of Klebsiella pneumoniae and CONS and 95.2% reduction of Bacillus species.
Conclusion
The use of 4% acetic acid solution significantly reduced more gram-positive than gram-negative organisms and is a highly effective disinfectant against Bacillus sp. but is not effective against gram-negative organisms as it does not fulfil the criteria of at least 90 percent reduction in bacterial growth. Chlorine tablet solution is a more effective disinfectant against gram-negative organisms than gram-positive organisms. Acetic acid 4% solution is not an effective alternative disinfectant to chlorine tablet solution, the currently used hospital disinfectant, but maybe used as an adjunct for better reduction of hospital environmental pathogens.
Acetic Acid
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Disinfectants
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Cross Infection
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Bacteria
8.Optimization of parameters for stir-frying of Kansui Radix with vinegar based on conversion of toxic components.
Han-Xiang LIU ; Yu-Song ZHANG ; Shi-Kang ZHOU ; Yi ZHANG ; Li ZHANG
China Journal of Chinese Materia Medica 2023;48(11):2958-2967
This study aims to optimize the parameters for stir-frying of Kansui Radix with vinegar based on the conversion of representative toxic diterpenes, which is expected to serve as a reference for the standardized production of Kansui Radix stir-fried with vinegar. To be specific, the toxic components [3-O-(2'E,4'Z-decadienoyl)-20-O-acetylingenol(3-O-EZ), kansuiphorin C(KPC)] in Kansui Radix and the products(ingenol, 20-deoxyingenol) after the stir-frying with vinegar were selected. The toxicity to intestine and water-draining activity were evaluated with NCM460(normal human colon mucosal epithelial cell line) and HT-29(a human colorectal adenocarcinoma cell line). An HPLC method was then developed to assess the conversion of toxic components. On this basis, temperature, time, and amount of vinegar for the processing of Kansui Radix were optimized with the Box-Behnken design and the content of ingenol and 20-deoxyingenol as evaluation index. The results showed that after the stir-frying of Kansui Radix with vinegar, 3-O-EZ and KPC were first converted to monoester 3-O-(2'E,4'Z-decadienoyl)ingenol(3-EZ) and 5-O-benzoyl-20-deoxyingenol(5-O-Ben) and finally to almost non-toxic ingenol and 20-deoxyingenol, respectively. Meanwhile, the water-draining activity was retained. Six compounds had a good linear relationship with the peak area in the corresponding concentration ranges(R~2≥0.999 8), and the average recovery fell in the range of 98.20%-102.3%(RSD≤2.4%). The content of representative diterpenes and intermediate products was 14.78%-24.67% lower in the Kansui Radix stir-fried with vinegar than in the Kansui Radix, while the content of the conversed products was 14.37%-71.37% higher. Among the process parameters, temperature had significant influence on the total content of products, followed by time. The optimal parameters were 210 ℃, 15 min, and 30% vinegar. The relative error between the experimental results and the predicted values was 1.68%, indicating that the process was stable and reproducible. The strategy of screening optimal parameters for stir-frying of Kansui Radix with vinegar based on the transformation of toxic components can help improve the production stability, reduce the toxicity, and ensure the efficacy of Kansui Radix stir-fried with vinegar, which can serve as a reference for the process optimization of similar toxic Chinese medicinals.
Humans
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Acetic Acid
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Euphorbia
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HT29 Cells
9.Effect of organic acids in dental biofilm on microhardness of a silorane-based composite.
Sedighe Sadat HASHEMIKAMANGAR ; Seyed Jalal POURHASHEMI ; Mohammad TALEBI ; Nazanin KIOMARSI ; Mohammad Javad KHARAZIFARD
Restorative Dentistry & Endodontics 2015;40(3):188-194
OBJECTIVES: This study evaluated the effect of lactic acid and acetic acid on the microhardness of a silorane-based composite compared to two methacrylate-based composite resins. MATERIALS AND METHODS: Thirty disc-shaped specimens each were fabricated of Filtek P90, Filtek Z250 and Filtek Z350XT. After measuring of Vickers microhardness, they were randomly divided into 3 subgroups (n = 10) and immersed in lactic acid, acetic acid or distilled water. Microhardness was measured after 48 hr and 7 day of immersion. Data were analyzed using repeated measures ANOVA (p < 0.05). The surfaces of two additional specimens were evaluated using a scanning electron microscope (SEM) before and after immersion. RESULTS: All groups showed a reduction in microhardness after 7 day of immersion (p < 0.001). At baseline and 7 day, the microhardness of Z250 was the greatest, followed by Z350 and P90 (p < 0.001). At 48 hr, the microhardness values of Z250 and Z350 were greater than P90 (p < 0.001 for both), but those of Z250 and Z350 were not significantly different (p = 0.095). Also, the effect of storage media on microhardness was not significant at baseline, but significant at 48 hr and after 7 day (p = 0.001 and p < 0.001, respectively). Lactic acid had the greatest effect. CONCLUSIONS: The microhardness of composites decreased after 7 day of immersion. The microhardness of P90 was lower than that of other composites. Lactic acid caused a greater reduction in microhardness compared to other solutions.
Acetic Acid
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Biofilms*
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Composite Resins
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Immersion
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Lactic Acid
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Water
10.Regulation of intracellular level of ATP and NADH in Escherichia coli to promote succinic acid production.
Xueming WANG ; Jingyu PAN ; Jing WU ; Xiulai CHEN ; Cong GAO ; Wei SONG ; Wanqing WEI ; Jia LIU ; Liming LIU
Chinese Journal of Biotechnology 2023;39(8):3236-3252
Succinic acid is an important C4 platform chemical that is widely used in food, chemical, medicine sectors. The bottleneck of fermentative production of succinic acid by engineered Escherichia coli is the imbalance of intracellular cofactors, which often leads to accumulation of by-products, lower yield and low productivity. Stoichiometric analysis indicated that an efficient production of succinic acid by E. coli FMME-N-26 under micro-aeration conditions might be achieved when the TCA cycle provides enough ATP and NADH for the r-TCA pathway. In order to promote succinic acid production, a serial of metabolic engineering strategies include reducing ATP consumption, strengthening ATP synthesis, blocking NADH competitive pathway and constructing NADH complementary pathway were developed. As result, an engineered E. coli FW-17 capable of producing 139.52 g/L succinic acid and 1.40 g/L acetic acid in 5 L fermenter, which were 17.81% higher and 67.59% lower than that of the control strain, was developed. Further scale-up experiments were carried out in a 1 000 L fermenter, and the titer of succinic acid and acetic acid were 140.2 g/L and 1.38 g/L, respectively.
Escherichia coli/genetics*
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NAD
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Succinic Acid
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Acetic Acid
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Adenosine Triphosphate