Darier's disease is a well-known genodermatosis characterized by recurrent waxy, hyperkeratotic papules usually occurring over the seborrheic area. The major histopathological changes are characteristic acantholysis and dyskeratosis which are diagnostic of the disease with typical clinical features. There are less common variants including the hypertrophic, vesicobullous and linear type. However, comedonal lesions are very rare. We report an unusual case of Darier's disease, which showed prominent comedonal papules and plaques over the face, scalp and upper trunk with the typical findings of Darier's disease.
Acantholysis ; Darier Disease* ; Scalp

No abstract available.
Acantholysis* ; Captopril* ; Penicillamine* ; Rifampin* ; Skin*

The histopathological findings of herpes virus infection of the skin are characterized as an intraepidermal vesicle formed by acantholysis with ballooning degeneration of keratinocytes and multinucleated keratinocytes. Involvement of follicular epithelium is known to occur as herpetic folliculitis. Although herpetic skin infection is very common, herpetic folliculitis is infrequently reported in the literature. It is important to confirm the diagnosis by histopathologic finding because of its atypically clinical manifestation. We report an unusual case in which typical clinical features of herpes virus infection were absent and histopathologically characterized by herpetic folliculitis without surface epithelium change.
Acantholysis ; Diagnosis ; Epithelium ; Folliculitis* ; Keratinocytes ; Skin

Localized perineal papules and plaques with acantholytic histology is characterized clinically by discrete and grouped papules, which are localized to the perineal or perianal areas. Histologically it shows focal suprabasal acantholysis. A 51-year-old man was referred to our department for verrucous skin lesions confined to perineal and perianal areas. Histopathologic findings of verrucous papule showed severe intraepidermal acantholysis. Although we do not know the precise nature or the incidence of this disease, localized perineal papules and plaques with acantholytic histology should be included in the differential diagnosis of verrucous papules in perineal or perianal areas.
Acantholysis ; Diagnosis, Differential ; Humans ; Incidence ; Middle Aged ; Skin

Acantholytic acanthoma is typically an asymptomatic, keratotic papule or nodule. In 1988, Brownstein described a previously unrecognized benign acanthoma, the acantholytic acanthoma. The term acantholytic is used because acantholysis is the outstanding histologic feature in this neoplasm; acanthoma is chosen because the growths are benign tumors of epidermal keratinocytes. On histopathology, these tumors may mimic pemphigus vulgaris, pemphigus vegetans, superficial pemphigus, or Hailey-Hailey disease, but had no evidence of any of these disorders. We report a case of acantholytic acanthoma seen on the inguinal area of a 79-year-old man who had a keratotic nodule on the left inguinal area.
Acantholysis ; Acanthoma* ; Aged ; Humans ; Keratinocytes ; Pemphigus ; Pemphigus, Benign Familial

Darier's disease is an uncommon genodermatosis, characterized by the symmetric eruption of keratotic papules, focal loss of epithelial adhesion and abnormal keratinization. A unilateral, or localized variant has been identified as a mosaic form, involving linear or 'zosteriform' epidermal lesions with clinical and histological features of Darier's disease. Some suggest that unilateral lesions should be classified as acantholytic dyskeratotic epidermal nevi, rather than localized Darier disease. A 17-year-old male presented with unilateral zosteriform distribution of brownish hyperkeratotic papules with ipsilateral v-notching of the thumb nail. A biopsy specimen revealed acantholysis, suprabasal cleft and multiple dyskeratotic cells. We report a case of unilateral Darier's disease which further supports unilateral dermatologic manifestation as a variant of Darier's disease.
Acantholysis ; Adolescent ; Biopsy ; Darier Disease ; Humans ; Keratins ; Male ; Nails ; Thumb

Darier's disease is an autosomal dominant disorder with altered keratinization of the epidermis, but many cases are sporadic and presumably represent new mutation. Multiple discrete, keratotic, asymptomatic or mild pruritic papules are present at not only the seborrheic areas but also oral mucosa, palm and sole. The histologic characteristic changes in Darier's disease are formation of corps ronds and grains, suprabasal acantholysis and villi. We experienced a case of Darier's disease with preceding lesions of palm and sole, so reported this case with literature review.
Acantholysis ; Edible Grain ; Darier Disease* ; Epidermis ; Mouth Mucosa

Acantholytic acanthoma is a benign neoplasm of the epidermal keratinocytes. It presents as a solitary, asympomatic, keratotic papule or nodule. The histopathologic features are outstanding acantholysis throughout the malpighian layer, hyperkeratosis, papillomatosis, and acanthosis. It is usually seen in older men, most commonly on the trunk. It has a tendency to be diagnosed clinically as a keratosis. Only 4 cases of acantholytic acanthoma have been reported in Korea. We report a case of acantholytic acanthoma in a 70-year-old man who presented with keratotic papules on his back.
Acantholysis ; Acanthoma* ; Aged ; Humans ; Keratinocytes ; Keratosis ; Korea ; Male ; Papilloma

A solitary acantholytic acanthoma is a benign tumor which presents as a solitary asymptomatic, keratotic papule or nodule. The acantholysis, implied in the term, is the histologic hallmark. It may mimic pemphigus vulgaris, pemphigus vegetans, or Hailey-Hailey disease, but displays no evidence of these disorders. We report a case of isolated acantholytic acanthoma in a 78-year-old man, where the histologic feature is focal acantholytic dyskeratosis.
Acantholysis ; Acanthoma* ; Aged ; Humans ; Pemphigus ; Pemphigus, Benign Familial

BACKGROUND: Squamous cell caircinoma(SCC) often shows acantholysis as a result of degenerative changes of neoplastic cells. Regurding the acantholytic changes of SCC most textbooks and literature describe the acantholysis-associated tubular or alveolar structures, which are diagnostic features of adenoid SCC. But the acantholytic changes of SCC are not always assaciated with tubular or alveolar structres. The general and detailed histologic features of acantholysis of SCC have not been reported. OBJECTIVE: We analyzed the histologic features of acantholysis of SCC . MEHTODS: Twenty six biopsy specimens from 26 patients with SCC were studied for the distributions and sites of acantholysis such as lefts and tubular or alveolar structurs on routine histologic staining. RESULTS: All 26 biopsy specimens showed acantholysis in their tumors ocal acantholysis was found in 12 cases, and diffuse, widesprcad acantholysis was found in 14 cascs. The foci of acantholysis were in the surface epidermis in 9 cases, in the follicular wall in 5 cases, and in both the surface epidermis and the follicuar wall in 12 cases. The types of acantholytic cells were either dyskeratotic cells or non-dyskeratotic squamous cells. Tuthular or alveolar structures were found in 5 cases. Clefts were found in 12 cases, one in the subcomealarea, the other 11 were within tumor mases, and one of them showed Darier-like feature with papillary projections of neoplastic cells into thc lumens. CONCLUSION: The acantholytic hanges of the SCC are more comrr on y found than expected. The acantholytic changes involve not only dyskeratotic cells but also non-dysL eratotic cells and often show glandular structures and clefts.
Acantholysis* ; Adenoids ; Biopsy ; Carcinoma, Squamous Cell* ; Dronabinol ; Epidermis ; Humans