Objective:To evaluate whether off pump coronary artery bypass grafting (OPCABG) has advantages over conventional coronary artery bypass grafting(CCABG). Methods:A total of 362 patients undergoing coronary artery bypass grafting were divided into 2 groups: OPCABG group:152 cases undergoing OPCABG and beating heart via sternotomy; CCABG group,210 cases undergoing CCABG with extracorporeal circulation. Preoperative and postoperative variables of 2 groups were compared. Results:There were no significant differences in sex, age, weight, acute or remote myocardium infarction, hypertension, diabetes and type of bypass grafts between 2 groups.The numbers of bridge vessels were not significantly different between the 2 groups; the incidences of low cardiac output syndrome, atrial fibrillation and atelectasis in OPCABG group were significantly less than those of CCABG group( P

Objective:To evaluate the therapeutic effectiveness of peritoneal dialysis(PD) for acute renal failure(ARF) following cardiac surgery with cardiopulmonary bypass and its effect on hemodynamics. Methods:Retrospective data from 88 patients with ARF following cardiac surgery undergoing PD were analyzed. Results:The renal function of the patients recovered within 3 to 39 d of PD, K +] declined to normal level within 1 d, HCO 3 -] declined to normal level within 1 4 d, and BUN and Cr declined by 49.2% and 42.6% respectively within 4 6 d of PD( P

Objective:To study the clinical characteristics of malignant lymphomas of the head and neck.Methods:The clinical data of 139 patients with malignant lymphomas of the head and neck were retrogradely analyzed,and the long term follow up was carried out.Results:Among all the cases there were 128 non Hodgkin's lymphoma(NHL) and 11 Hodgkin's disease(HD). The average ages of patients with HD and NHL were 41.8 and 50.0 years old respectively.There were lymphadenopathy in all patients with HD and 72.7% of those with NHL. Extranodal involvement occurred in 27.3% HD patients and 75.8% NHL patients; general symptoms appeared in 45.5% HD patients and 37.5% NHL patients. Most patients received chemotherapy of CHOP and improved CHOP scheme.The average follow up time was 23.4 months. Twelve patients died and the 3 year survival rate was 55.6%.Conclusion:In our group, the patients present an older age and NHL is more common than HD.The cases with cervical lymphadenopathy are easy to be diagnosed,and the clinical stage classification is useful for the prognosis.

Objective:To study the relationship between hyperviscosity syndrome(HVS) and platelet membrane glycoproteins(GP) sub group changes.Methods: CD62P,CD63,CD31 and CD41 were measured by flow cytometry(FCM). The hemorrheoloic parameters of HVS patients were compared with those of normal aged group and normal young group.Results:(1)The CD62P,CD63 and CD31 of aged and young HVS patients before therapy were obviously higher than those of the normal aged group and normal young group.(2)Combined measurement could improve the detecting positive rate of HVS patients up to 92% 100%, with the sensitivity being 95.3%.(3)Bamyl decreased CD62P,CD63 and CD31,which was obviously correlated with ?b and ?p. Conclusion:The alteration of platelet membrane GP positive expression may be a parameter for early diagnosis and clinical outcome observation.

Interleukin 24(IL 24),also called the melanoma differentiation associated gene 7(MDA 7),is stably expressed in human tissues associated with the immune system such as the spleen,thymus,peripheral blood leukocytes and normal melanocytes. IL 24 binds to IL 20 and IL 22 receptor complexes(IL 22R1/IL 20R2 and IL 20R1/IL 20R2),and induces secretion of high levels of IL 6,TNF alpha,and IFN gamma and low levels of IL 1beta,IL 12,and GM CSF from human PBMC. Adenoviral IL 24(Ad IL 24) induces growth suppression and apoptosis selectively in diverse human cancers and tumor cell lines without producing any apparent harmful effect in normal cells. The effects of Ad IL 24 are associated to the ratio of pro apoptotic(BAX,BAK) to anti apoptotic(Bcl 2) proteins,and the up regulation of p38 MAPK and a family of growth arrest and DNA damage(GADD) inducible genes. These demonstrate the potential therapeutic effects of Ad IL 24 in human cancer.

ATP binding cassette transporter (ABCT),a membrane transporting protein existing in mammalian, bacterial, fungal and many other types of cells, is correlated with multidrug resistance in many cells. To date 10 ABCT have been described in Candida albicans , but only CDR1 and CDR2 genes were associated with multidrug resistance. Moreover, their encoding proteins Cdr1p and Cdr2p have many functions such as efflux pump and phospholipid translocator. The progress in the study of Cdr1p and Cdr2p proteins mediating multidrug resistance in Candida albicans was summarized in the paper.

0.05) and systolic velocity of regional myocardium, the difference between Ven and Vep, and mitral valve annulus have improved during the follow up study( P

Objective:To examine whether somatostatin analogous(SSAs) have effect on Graves ophthalmopathy and to compare its effects with that of glucocorticoid.Methods: Both a computer aided search of MEDLINE and Chinese Biological Medicine disc and an intensive search by hand were conducted to identify all controlled studies assessing the effect of SSAs on Graves ophthalmopathy.Results: Five studies were finally included.Three of them found SSAs to be significantly more effective than placebo;2 of them found SSAs to be able to reduce proptosis; 2 of them found SSAs to be equally effctive as glucocorticoid.The pooled OR, pooled mean difference, pooled OR were 0.070.02,0.23],-1.47 -2.10,-0.84] and 0.95 0.25,3.59] respectively.Conclusion: This Meta analysis demonstrates that SSAs are effective in treatment of Graves ophthalmopathy and in reduction of proptosis, and it is equally effctive as glucocorticoid.

Objective:To assess the relative stability and kinematics of the lumbar intervertebral segmental stiffness among posterior lumbar interbody fusion(PLIF) using one anatomical posterolateral cage with or without transpedicular screw rod fixation. Methods: Each of the 6 bovine lumbar functional spinal units(FSV) was tested under 6 different treatments. Test order was intact and every group differed in internal fixation of transpedicular screw. Group 1 referred to the normal lumbar functional spinal units. Group 2 was treated by left unilateral facetectomy and discoidectomy. Group 3 had anatomical threaded cages inserted on the left. Group 4 had anatomical threaded cages inserted on the left and fixed by right transpedicular screws. Group 5 had left inserted anatomical threaded cages and was fixed by left transpedicular screws. Group 6 had anatomical threaded cages inserted on the left side and was fixed by bilateral transpedicular screws. Nondestructive tests were performed in pure compression, flexion, extension, and lateral bending. Results: Unilateral discectomy and facetectomy had lower stiffness than normal FSU by 69% and 44% in pure compression, flexion, extension, and lateral bending. Single anatomical posterolateral cage group had higher stiffness than discectomy and facetectomy group, up by 55% and 28%. However, its stiffness was lower than normal FSU by 41% and 23%. Single anatomical cage with unilateral transpedicular screw fixation (left or right) had higher stiffness than normal FSU by 15% 17% and 20% 50% respectively. Single anatomical cage with transpedicular screw fixation was much stiffer than normal FSU by 18% and 65%. Conclusion: Adequate postoperative stability can be achieved by posterior lumbar interbody fusion with insertion of a single anatomical cage combined with a transpedicular screw.

Objective:To investigate the effects of chitosan on experimental rabbit atherosclerosis(AS).Methods:The models of rabbit AS were produced by a high fat diet.The rabbits were randomly assigned into normal diet(ND) group,high fat diet(HFD) group,chitosan and high fat diet(CHFD) group,chitosan and normal diet(CND) group.Fasting blood samples were collected for serum lipid assay on 0,4,8 weeks;the animals were killed on the 8th week to make aorta samples.AS plaque areas were estimated in the descending aorta dyed with oil red O and the ascending aorta dyed with H E.Results:TG,TC,LDL C in the CHFD group were lower than those in HFD group on 4 and 8 weeks;serum lipid concentration in ND group was similar with that in CND group;plaque areas in CHFD group were smaller than those in HFD group;intima thickness in CHFD group was thinner than that in HFD group.Conclusion:Chitosan reduces AS degree in rabbits of HFD group,which might be related to the decrease of serum lipid.